Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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C129902-200mg | 200mg | In stock | $17.90 | |
C129902-1g | 1g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $72.90 | |
C129902-5g | 5g | In stock | $215.90 | |
C129902-25g | 25g | In stock | $972.90 |
Potent β-lactamase inhibitor. Antibiotic agent.
Synonyms | Cefoperazone [INN:BAN] | EINECS 263-749-4 | (6R,7R)-7-{[(2R)-2-{[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino}-2-(4-hydroxyphenyl)acetyl]amino}-3-{[(1-methyl-1H-tetrazol-5-yl)thio]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid | CE |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Cefoperazone Acid is an antimicrobial agent that possesses potent LACTB (β-lactamase) inhibitory properties.Potent β-lactamase inhibitor. Antibiotic agent. Inhibits peptidoglycan synthesis. Active against Pseudomonas. Shows broad spectrum bactericidal eff |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Grade | Moligand™ |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Cefoperazone is a cephalosporin antibiotic for inhibition of rMrp2-mediated [3H]E217βG uptake with IC50 of 199 μM. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | (6R,7R)-7-[[(2R)-2-[(4-ethyl-2,3-dioxopiperazine-1-carbonyl)amino]-2-(4-hydroxyphenyl)acetyl]amino]-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid |
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INCHI | InChI=1S/C25H27N9O8S2/c1-3-32-8-9-33(21(39)20(32)38)24(42)27-15(12-4-6-14(35)7-5-12)18(36)26-16-19(37)34-17(23(40)41)13(10-43-22(16)34)11-44-25-28-29-30-31(25)2/h4-7,15-16,22,35H,3,8-11H2,1-2H3,(H,26,36)(H,27,42)(H,40,41)/t15-,16-,22-/m1/s1 |
InChi Key | GCFBRXLSHGKWDP-XCGNWRKASA-N |
Canonical SMILES | CCN1CCN(C(=O)C1=O)C(=O)NC(C2=CC=C(C=C2)O)C(=O)NC3C4N(C3=O)C(=C(CS4)CSC5=NN=NN5C)C(=O)O |
Isomeric SMILES | CCN1CCN(C(=O)C1=O)C(=O)N[C@H](C2=CC=C(C=C2)O)C(=O)N[C@H]3[C@@H]4N(C3=O)C(=C(CS4)CSC5=NN=NN5C)C(=O)O |
PubChem CID | 44187 |
Molecular Weight | 645.67 |
CAS Registry No. | 62893-19-0 |
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ChEBI | CHEBI:3493 |
ChEMBL Ligand | CHEMBL507674 |
DrugBank Ligand | DB01329 |
DrugCentral Ligand | 543 |
PubChem CID | 44187 |
Wikipedia | Cefoperazone |
Antibiotic DB | 1909 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
B1525019 | Certificate of Analysis | Jun 05, 2024 | C129902 |
D2407043 | Certificate of Analysis | Apr 10, 2024 | C129902 |
A2206694 | Certificate of Analysis | Oct 20, 2023 | C129902 |
A2206764 | Certificate of Analysis | Oct 20, 2023 | C129902 |
A2206766 | Certificate of Analysis | Oct 20, 2023 | C129902 |
A2206799 | Certificate of Analysis | Oct 20, 2023 | C129902 |
D2407044 | Certificate of Analysis | Oct 20, 2023 | C129902 |
Solubility | DMSO 129 mg/mL Water <1 mg/mL Ethanol <1 mg/mL |
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Sensitivity | Heat Sensitive |
Melt Point(°C) | 173 °C(dec.) |
Pictogram(s) | GHS08, GHS07 |
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Signal | Danger |
Hazard Statements | H317:May cause an allergic skin reaction H334:May cause allergy or asthma symptoms or breathing difficulties if inhaled |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P501:Dispose of contents/container to ... P284:[In case of inadequate ventilation] Wear respiratory protection. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P342+P316:If experiencing respiratory symptoms: Get emergence medical help immediately. |
Merck Index | 1930 |
1. Yexuan Mao, Yichao Fan, Ran Yang, Youyi Wang, Qingyue Li, Meng Dang, Xianqing Huang, Lianjun Song, Pingan Zhang, Miao Song, Liang Liu, Linli Wang, Shun Yu, Qiuyan Zhao, Xiya Zhang. (2023) A highly sensitive electrochemical sensor derived from peptide amphiphilic inspired self-assembled, ordered gold nanoparticles for determination of 22 β-lactams. ELECTROCHIMICA ACTA, 461 (142669). [PMID:] [10.1016/j.electacta.2023.142669] |
2. Shuangmin Wu, Wei Shen, Yushuang Chen, Yongli Zhu, Ren Hou, Menghong Dai, Dapeng Peng. (2022) Rapid Determination of Cephalexin in Animal-Derived Food by an Indirect Competitive Enzyme-Linked Immunosorbent Assay. ANALYTICAL LETTERS, 55 (17): (2803-2816). [PMID:] [10.1080/00032719.2022.2072857] |
3. Menghan Qin, Yumiao Shi, Dingkun Lu, Jingjing Deng, Guoyue Shi, Tianshu Zhou. (2022) High-performance Hf/Ti-doped defective Zr-MOFs for cefoperazone adsorption: Behavior and mechanisms. APPLIED SURFACE SCIENCE, 595 (153494). [PMID:] [10.1016/j.apsusc.2022.153494] |
1. Matsubara N, Minami S, Muraoka T, Saikawa I, Mitsuhashi S. (1979) In vitro antibacterial activity of cefoperazone (T-1551), a new semisynthetic cephalosporin.. Antimicrob Agents Chemother, 16 (6): (731-5). [PMID:316988] [10.1021/op500134e] |
2. Yexuan Mao, Yichao Fan, Ran Yang, Youyi Wang, Qingyue Li, Meng Dang, Xianqing Huang, Lianjun Song, Pingan Zhang, Miao Song, Liang Liu, Linli Wang, Shun Yu, Qiuyan Zhao, Xiya Zhang. (2023) A highly sensitive electrochemical sensor derived from peptide amphiphilic inspired self-assembled, ordered gold nanoparticles for determination of 22 β-lactams. ELECTROCHIMICA ACTA, 461 (142669). [PMID:] [10.1016/j.electacta.2023.142669] |
3. Shuangmin Wu, Wei Shen, Yushuang Chen, Yongli Zhu, Ren Hou, Menghong Dai, Dapeng Peng. (2022) Rapid Determination of Cephalexin in Animal-Derived Food by an Indirect Competitive Enzyme-Linked Immunosorbent Assay. ANALYTICAL LETTERS, 55 (17): (2803-2816). [PMID:] [10.1080/00032719.2022.2072857] |
4. Menghan Qin, Yumiao Shi, Dingkun Lu, Jingjing Deng, Guoyue Shi, Tianshu Zhou. (2022) High-performance Hf/Ti-doped defective Zr-MOFs for cefoperazone adsorption: Behavior and mechanisms. APPLIED SURFACE SCIENCE, 595 (153494). [PMID:] [10.1016/j.apsusc.2022.153494] |