Grouped product items

SKU

Size

Availability

Price

Qty

C608460-5mg

5mg

Available within 8-12 weeks(?)

$1,334.90

C608460-25mg

25mg

Available within 8-12 weeks(?)

$2,001.90

Basic Description

Synonyms	AKOS015913487 \| Ceftaroline fosamil anhydrous \| Ceftaroline Fosamil Inner salt \| SCHEMBL1464037 \| BDBM50482776 \| (6R,7R)-7-(((2Z)-2-(ethoxyimino)-2-(5-(phosphonoamino)-1,2,4-thiadiazol-3-yl)acetyl)amino)-3-((4-(1-methylpyridinium-4-yl)-1,3-thiazol-2-yl)su
Specifications & Purity	Moligand™
Grade	Moligand™

Associated Targets(Human)

Homo sapiens (32628 Activities)

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Associated Targets(non-human)

mrcA Penicillin-binding protein 1A (31 Activities)

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mrdA Penicillin-binding protein 2 (41 Activities)

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pbp4 Penicillin-binding protein 4 (13 Activities)

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pbp1 Penicillin-binding protein 1 (3 Activities)

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Schaalia meyeri (78 Activities)

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Streptococcus pneumoniae (31063 Activities)

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Enterococcus (1748 Activities)

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Collinsella aerofaciens (60 Activities)

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Streptococcus viridans (303 Activities)

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Eggerthella lenta (139 Activities)

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Pseudomonas aeruginosa (123386 Activities)

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Burkholderia cepacia (649 Activities)

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Enterobacter cloacae (7976 Activities)

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Klebsiella pneumoniae (43867 Activities)

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Proteus vulgaris (5823 Activities)

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Providencia rettgeri (925 Activities)

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Providencia sp. (46 Activities)

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Shigella sp. (79 Activities)

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Pasteurella multocida (1166 Activities)

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Bacteroides fragilis (1445 Activities)

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Bacteroides thetaiotaomicron (562 Activities)

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Parabacteroides distasonis (282 Activities)

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Fusobacterium mortiferum (179 Activities)

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Fusobacterium varium (184 Activities)

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Fusobacterium necrophorum (183 Activities)

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Peptoniphilus asaccharolyticus (368 Activities)

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Peptostreptococcus anaerobius (347 Activities)

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Staphylococcus aureus (210822 Activities)

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Acinetobacter (437 Activities)

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Moraxella catarrhalis (3334 Activities)

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Neisseria meningitidis (411 Activities)

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Enterobacteriaceae (669 Activities)

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Citrobacter freundii (1864 Activities)

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Klebsiella aerogenes (4963 Activities)

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Escherichia coli (133304 Activities)

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Morganella morganii (1291 Activities)

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Proteus mirabilis (3894 Activities)

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Providencia stuartii (425 Activities)

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Salmonella sp. (105 Activities)

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Serratia marcescens (3237 Activities)

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Haemophilus influenzae (8812 Activities)

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Bacteroides uniformis (255 Activities)

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Phocaeicola vulgatus (440 Activities)

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Hoylesella loescheii (67 Activities)

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Fusobacterium nucleatum (386 Activities)

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Finegoldia magna (323 Activities)

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Peptostreptococcus sp. (78 Activities)

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Staphylococcus (1598 Activities)

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Streptococcus agalactiae (1777 Activities)

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Streptococcus pyogenes (16140 Activities)

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Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	(6R,7R)-7-[[(2Z)-2-ethoxyimino-2-[5-(phosphonoamino)-1,2,4-thiadiazol-3-yl]acetyl]amino]-3-[[4-(1-methylpyridin-1-ium-4-yl)-1,3-thiazol-2-yl]sulfanyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
INCHI	InChI=1S/C22H21N8O8PS4/c1-3-38-26-13(16-25-21(43-28-16)27-39(35,36)37)17(31)24-14-18(32)30-15(20(33)34)12(9-40-19(14)30)42-22-23-11(8-41-22)10-4-6-29(2)7-5-10/h4-8,14,19H,3,9H2,1-2H3,(H4-,24,25,27,28,31,33,34,35,36,37)/b26-13-/t14-,19-/m1/s1
InChi Key	ZCCUWMICIWSJIX-NQJJCJBVSA-N
Canonical SMILES	CCON=C(C1=NSC(=N1)NP(=O)(O)O)C(=O)NC2C3N(C2=O)C(=C(CS3)SC4=NC(=CS4)C5=CC=[N+](C=C5)C)C(=O)[O-]
Isomeric SMILES	CCO/N=C(/C1=NSC(=N1)NP(=O)(O)O)\C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)SC4=NC(=CS4)C5=CC=[N+](C=C5)C)C(=O)[O-]
PubChem CID	9852981
Molecular Weight	684.68

Database links

PubChem CID	9852981
ChEMBL Ligand	CHEMBL501122
DrugBank Ligand	DB06590
CAS Registry No.	229016-73-3
Antibiotic DB	1444, 1419
DrugCentral Ligand	4169

Certificates

Certificate of Analysis(COA)

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References

1. Jacobs MR, Good CE, Windau AR, Bajaksouzian S, Biek D, Critchley IA, Sader HS, Jones RN. (2010) Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States.. Antimicrob Agents Chemother, 54 (6): (2716-9). [PMID:20308374]
2. Duplessis C, Crum-Cianflone NF. (2011) Ceftaroline: A New Cephalosporin with Activity against Methicillin-Resistant Staphylococcus aureus (MRSA).. Clin Med Rev Ther, 3 (13): (1755-70). [PMID:21785568]
3. Ge Y, Biek D, Talbot GH, Sahm DF. (2008) In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States.. Antimicrob Agents Chemother, 52 (9): (3398-407). [PMID:18625769]

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ceftaroline fosamil , CAS No.229016-73-3

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Related Documents

References

Solution Calculators

Molarity Calculator

Dilution Calculator

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SKU	Size	Availability	Price	Qty
C608460-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
C608460-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,001.90