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Ceftizoxime - >98.0%(HPLC), high purity , CAS No.68401-81-0
Basic Description Synonyms ceftizoxime|68401-81-0|Ceftizoxima|Ceftizoximum|Cefizox|Ceftizoximum [INN-Latin]|Ceftizoxima [INN-Spanish]|FK-749|Ceftizoxime (INN)|syn-7-(2-(2-Amino-4-thiazolyl)-2-methoxyiminoacetamido)-3-cephem-4-carboxylic acid|SKF-88373|Epocelin|C43C467DPE|(6R,7R)-7- Specifications & Purity >98.0%(HPLC) Shipped In Normal Grade Moligand™ Product Description Product Description:
Ceftizoxime is a bacterial inhibitor which acts by interfering with bacterial cell wall synthesis and inhibiting cross-linking of the peptidoglycan.
Names and Identifiers Pubchem Sid 488195842 Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488195842 IUPAC Name (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid INCHI InChI=1S/C13H13N5O5S2/c1-23-17-7(5-4-25-13(14)15-5)9(19)16-8-10(20)18-6(12(21)22)2-3-24-11(8)18/h2,4,8,11H,3H2,1H3,(H2,14,15)(H,16,19)(H,21,22)/b17-7-/t8-,11-/m1/s1 InChi Key NNULBSISHYWZJU-LLKWHZGFSA-N Canonical SMILES CON=C(C1=CSC(=N1)N)C(=O)NC2C3N(C2=O)C(=CCS3)C(=O)O Isomeric SMILES CO/N=C(/C1=CSC(=N1)N)\C(=O)N[C@H]2[C@@H]3N(C2=O)C(=CCS3)C(=O)O RTECS XI0367375 PubChem CID 6533629 Molecular Weight 383.4 Reaxy-Rn 5777502
Chemical and Physical Properties Specific Rotation[α] 139° (C=1,0.1mol/L NaOH 3mL+H2O 7mL) Melt Point(°C) 227°C
Safety and Hazards(GHS) Pictogram(s) GHS08 , GHS07 Signal Danger Hazard Statements H317: May cause an allergic skin reaction
H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P501: Dispose of contents/container to ...
P284: [In case of inadequate ventilation] Wear respiratory protection.
P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P272: Contaminated work clothing should not be allowed out of the workplace.
P333+P313: IF SKIN irritation or rash occurs: Get medical advice/attention.
P362+P364: Take off contaminated clothing and wash it before reuse.
P342+P316: If experiencing respiratory symptoms: Get emergence medical help immediately.
RTECS XI0367375 Reaxy-Rn 5777502 Merck Index 1951
References 1. Cui L, Neoh HM, Shoji M, Hiramatsu K. (2009) Contribution of vraSR and graSR point mutations to vancomycin resistance in vancomycin-intermediate Staphylococcus aureus.. Antimicrob Agents Chemother, 53 (3): (1231-4). [PMID:19124662 ] 2. Blaszczak LC, Brown RF, Cook GK, Hornback WJ, Hoying RC, Indelicato JM, Jordan CL, Katner AS, Kinnick MD, McDonald 3rd JH et al. . (1990) Comparative reactivity of 1-carba-1-dethiacephalosporins with cephalosporins.. J Med Chem, 33 (6): (1656-62). [PMID:2342058 ]
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