Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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SKU | Size | Availability | Price | Qty |
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C608465-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $29.90 | |
C608465-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $89.90 | |
C608465-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $379.90 |
Synonyms | BAL 9141 | BAL 9141-000 | Ro 63-9141 | (6R,7R)-7-[[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-ylidene)- 2-nitroso-1-oxoethyl]amino]-8-oxo-3-[(E)-[2-oxo-1-[(3R)- 3-pyrrolidinyl]-3-pyrrolidinylidene]methyl]-5-thia-1- azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Ceftobiprole is a fifth generation broad spectrum cephalosporin that is active against many resistant bacterial strains including methicillin-resistant Staphylococcus aureus (MRSA). Ceftobiprole inhabits PBP1 (penicillin-binding protein 1), PBP2 and ß-lac |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Bacterial penicillin-binding protein inhibitor |
Product Description | eftobiprole (Ro 63-9141) is a broad-spectrum cephalosporin with high levels of in vitro activity against methicillin- (MRSA) and vancomycin-resistant staphylococci (VRSA) and penicillin-resistant streptococci with a MIC90 value of 2 μg/mL for MRSA. Ceftobiprole also inhibits gram-positive and gram-negative pathogens |
ALogP | -2.4 |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | (6R,7R)-7-[[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-hydroxyiminoacetyl]amino]-8-oxo-3-[(E)-[2-oxo-1-[(3R)-pyrrolidin-3-yl]pyrrolidin-3-ylidene]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid |
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INCHI | InChI=1S/C20H22N8O6S2/c21-20-24-14(26-36-20)11(25-34)15(29)23-12-17(31)28-13(19(32)33)9(7-35-18(12)28)5-8-2-4-27(16(8)30)10-1-3-22-6-10/h5,10,12,18,22,34H,1-4,6-7H2,(H,23,29)(H,32,33)(H2,21,24,26)/b8-5+,25-11-/t10-,12-,18-/m1/s1 |
InChi Key | VOAZJEPQLGBXGO-SDAWRPRTSA-N |
Canonical SMILES | O/N=C(/c1nsc(n1)N)\C(=O)N[C@@H]1C(=O)N2[C@@H]1SCC(=C2C(=O)O)/C=C/1\CCN(C1=O)[C@H]1CNCC1 |
Isomeric SMILES | C1CNC[C@@H]1N2CC/C(=C\C3=C(N4[C@@H]([C@@H](C4=O)NC(=O)/C(=N\O)/C5=NSC(=N5)N)SC3)C(=O)O)/C2=O |
PubChem CID | 135413542 |
Molecular Weight | 534.57 |
CAS Registry No. | 209467-52-7 |
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PubChem CID | 135413542 |
ChEMBL Ligand | CHEMBL520642 |
Antibiotic DB | 91 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
E2430205 | Certificate of Analysis | Apr 17, 2024 | C608465 |
E2430206 | Certificate of Analysis | Apr 17, 2024 | C608465 |
E2430207 | Certificate of Analysis | Apr 17, 2024 | C608465 |
E2430208 | Certificate of Analysis | Apr 17, 2024 | C608465 |
E2430209 | Certificate of Analysis | Apr 17, 2024 | C608465 |
E2430210 | Certificate of Analysis | Apr 17, 2024 | C608465 |
1. Morosini MI, Díez-Aguilar M, Cantón R. (2019) Mechanisms of action and antimicrobial activity of ceftobiprole.. Rev Esp Quimioter, 32 Suppl 3 (13): (3-10). [PMID:31364335] [10.1021/op500134e] |