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Celastrol - 98%, high purity , CAS No.34157-83-0 6 Citations
Anti-inflammatory and antiproliferative agent
Basic Description Synonyms celastrol | 34157-83-0 | Tripterin | Tripterine | (2R,4aS,6aS,12bR,14aS,14bR)-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydropicene-2-carboxylic acid | NSC70931 | (2R,4aS,6aR,6aS,14aS,14bR)-10-hydroxy-2,4a,6a,6a,9, Specifications & Purity 98% Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Grade Moligand™ Product Description Celastrol, Celastrus scandens, a compound originally purified from Tripterygium wilfordii, has been shown to be an anti-peroxidative and anti-angiogenic agent. Mechanistic studies suggest that Celastrol suppresses levels of VEGF and Flk-1 receptors, VEGFR-1 and VEGFR-2, which may reduce signal transduction between the two growth factors. Additionally, Celastrol has demonstrated the ability to disrupt critical interaction of Glu33 (Hsp90) and Arg167 (Cdc37) in the superchaperone complex which causes anti-proliferative activity in vitro and inhibit Topo II (topoisomerase II) activity in vitro (IC50 = 7.41 μM). Celastrol, Celastrus scandens is an inhibitor of Hsp90.
Associated Targets(Human) Names and Identifiers IUPAC Name (2R,4aS,6aR,6aS,14aS,14bR)-10-hydroxy-2,4a,6a,6a,9,14a-hexamethyl-11-oxo-1,3,4,5,6,13,14,14b-octahydropicene-2-carboxylic acid INCHI InChI=1S/C29H38O4/c1-17-18-7-8-21-27(4,19(18)15-20(30)23(17)31)12-14-29(6)22-16-26(3,24(32)33)10-9-25(22,2)11-13-28(21,29)5/h7-8,15,22,31H,9-14,16H2,1-6H3,(H,32,33)/t22-,25-,26-,27+,28-,29+/m1/s1 InChi Key KQJSQWZMSAGSHN-JJWQIEBTSA-N Canonical SMILES CC1=C(C(=O)C=C2C1=CC=C3C2(CCC4(C3(CCC5(C4CC(CC5)(C)C(=O)O)C)C)C)C)O Isomeric SMILES CC1=C(C(=O)C=C2C1=CC=C3[C@]2(CC[C@@]4([C@@]3(CC[C@@]5([C@H]4C[C@](CC5)(C)C(=O)O)C)C)C)C)O WGK Germany 2 Alternate CAS 34157-83-0 PubChem CID 122724 NSC Number 70931 UN Number 2811 MeSH Entry Terms 3-hydroxy-24-nor-2-oxo-1(10),3,5,7-friedelatetraen-29-oic acid;celastrol;tripterin;tripterine Molecular Weight 450.61
Chemical and Physical Properties Solubility Soluble in DMSO (>10 mg/ml), ethanol, DMF:PBS(pH 7.2)(1:10), and DMF. Insoluble in water. Sensitivity Heat sensitive Specific Rotation[α] -122.7° (C=0.1,CHCl3) Melt Point(°C) 203°C(lit.)
Safety and Hazards(GHS) Pictogram(s) GHS06 Signal Danger Hazard Statements H301: Toxic if swallowed
Precautionary Statements P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P301+P316: IF SWALLOWED: Get emergency medical help immediately.
WGK Germany 2
Citations of This Product 1. Ping Sheng, Chao Bu, Tanyue Hui, Lili Zhou, Hao Chen, Guoliang Zhou. (2023) Polydopamine-activated celastrol carbon dots for synergistic chemotherapy-photothermal therapy of tumors. International Journal of Pharmaceutics-X, 6 (7): (100218). [PMID:38033396 ] 2. Jiwen Fan, Meng Ren, Weiwei Chen, Haodong Wang, Yuquan He. (2023) Celastrol relieves myocardial infarction-induced cardiac fibrosis by inhibiting NLRP3 inflammasomes in rats. INTERNATIONAL IMMUNOPHARMACOLOGY, 121 (110511). [PMID:37343368 ] 3. Xiaoli Li, Guangbei Zhu, Xintong Yao, Ning Wang, Ronghui Hu, Qingxin Kong, Duanfang Zhou, Liangyuan Long, Jiali Cai, Weiying Zhou. (2022) Celastrol induces ubiquitin-dependent degradation of mTOR in breast cancer cells. OncoTargets and Therapy, [PMID:30588010 ] 4. Qiang Chen, Chunjing Guo, Zhongxin Liu, Min Cao, Wenxin Wang, Dandan Zhang, Hongxu Geng, Ningning Diao, Daquan Chen. (2023) Multifunctional nanoparticles with anti-inflammatory effect for improving metabolic syndromes. JOURNAL OF DRUG TARGETING, 31 (3): (286-295). [PMID:36315421 ] 5. Bo Yu, Yiping Shen, Xuejie Zhang, Lijuan Ding, Zheng Meng, Xiaotong Wang, Meihua Han, Yifei Guo, Xiangtao Wang. (2022) Poly(methacrylate citric acid) as a Dual Functional Carrier for Tumor Therapy. Pharmaceutics, 14 (9): (1765). [PMID:36145512 ] 6. Yunpeng Qi,Renping Wang,Liang Zhao,Lei Lv,Fan Zhou,Tian Zhang,Feng Lu,Hongli Yan,Gengli Duan. (2018-08-03) Celastrol Suppresses Tryptophan Catabolism in Human Colon Cancer Cells as Revealed by Metabolic Profiling and Targeted Metabolite Analysis.. Biological & pharmaceutical bulletin, 41 ((8)): (1243-1250). [PMID:30068874 ]
References 1. Ping Sheng, Chao Bu, Tanyue Hui, Lili Zhou, Hao Chen, Guoliang Zhou. (2023) Polydopamine-activated celastrol carbon dots for synergistic chemotherapy-photothermal therapy of tumors. International Journal of Pharmaceutics-X, 6 (7): (100218). [PMID:38033396 ] 2. Jiwen Fan, Meng Ren, Weiwei Chen, Haodong Wang, Yuquan He. (2023) Celastrol relieves myocardial infarction-induced cardiac fibrosis by inhibiting NLRP3 inflammasomes in rats. INTERNATIONAL IMMUNOPHARMACOLOGY, 121 (110511). [PMID:37343368 ] 3. Xiaoli Li, Guangbei Zhu, Xintong Yao, Ning Wang, Ronghui Hu, Qingxin Kong, Duanfang Zhou, Liangyuan Long, Jiali Cai, Weiying Zhou. (2022) Celastrol induces ubiquitin-dependent degradation of mTOR in breast cancer cells. OncoTargets and Therapy, [PMID:30588010 ] 4. Qiang Chen, Chunjing Guo, Zhongxin Liu, Min Cao, Wenxin Wang, Dandan Zhang, Hongxu Geng, Ningning Diao, Daquan Chen. (2023) Multifunctional nanoparticles with anti-inflammatory effect for improving metabolic syndromes. JOURNAL OF DRUG TARGETING, 31 (3): (286-295). [PMID:36315421 ] 5. Bo Yu, Yiping Shen, Xuejie Zhang, Lijuan Ding, Zheng Meng, Xiaotong Wang, Meihua Han, Yifei Guo, Xiangtao Wang. (2022) Poly(methacrylate citric acid) as a Dual Functional Carrier for Tumor Therapy. Pharmaceutics, 14 (9): (1765). [PMID:36145512 ] 6. Yunpeng Qi,Renping Wang,Liang Zhao,Lei Lv,Fan Zhou,Tian Zhang,Feng Lu,Hongli Yan,Gengli Duan. (2018-08-03) Celastrol Suppresses Tryptophan Catabolism in Human Colon Cancer Cells as Revealed by Metabolic Profiling and Targeted Metabolite Analysis.. Biological & pharmaceutical bulletin, 41 ((8)): (1243-1250). [PMID:30068874 ]
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