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cenicriviroc - 97%, high purity , C-C chemokine receptor type 2 antagonist, CAS No.497223-25-3, C-C chemokine receptor type 2 antagonist

Moligand™
≥97%

CAS#: 497223-25-3
Formula: C₄₁H₅₂N₄O₄S
Molecular Weight: 696.95
PubChem CID: 11285792

Item Number

C176619

Grouped product items
SKU	Size	Availability	Price
C176619-1mg	1mg	In stock	$41.90
C176619-5mg	5mg	In stock	$173.90
C176619-25mg	25mg	In stock	$565.90
C176619-100mg	100mg	In stock	$1,708.90

View related series

CCR5 Antagonist

Basic Description

Synonyms	Cenicriviroc\|497223-25-3\|TBR-652\|TAK-652\|TBR652\|TBR 652\|15C116UA4Y\|497223-25-3 (free base)\|(-)-8-(4-(2-butoxyethoxy)phenyl)-1-isobutyl-n-(4-(((1-propyl-1H-imidazol-5-yl)methyl)sulfinyl)phenyl)-1,2,3,4-tetrahydro-1-benzazocine-5-carboxamide\|(S,E)-8-(4-(2-b
Specifications & Purity	97%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	C-C chemokine receptor type 2 antagonist
Product Description	application： Cenicriviroc is an experimental drug candidate for the treatment of HIV infection. It is an inhibitor of CCR2 and CCR5 receptors, allowing it to function as an entry inhibitor which prevents the virus from entering into a human cell. general description： Cenicriviroc (CVC, TAK-652, TBR-652) is a potent inhibitor of CC chemokine receptor 2 (CCR2) and CCR5. Cenicriviroc also inhibits HIV-1 and HIV-2 with potent anti-inflammatory and antiinfective activity.

Associated Targets

CCR2 Tchem C-C chemokine receptor type 2 2 Activities

Discover Target: CCR2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CCR7 Tchem C-C chemokine receptor type 7 1 Activities

Discover Target: CCR7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CCR5 Tclin C-C chemokine receptor type 5 2 Activities

Discover Target: CCR5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	(5E)-8-[4-(2-butoxyethoxy)phenyl]-1-(2-methylpropyl)-N-[4-[(S)-(3-propylimidazol-4-yl)methylsulfinyl]phenyl]-3,4-dihydro-2H-1-benzazocine-5-carboxamide
INCHI	InChI=1S/C41H52N4O4S/c1-5-7-22-48-23-24-49-38-15-10-32(11-16-38)33-12-19-40-35(25-33)26-34(9-8-21-44(40)28-31(3)4)41(46)43-36-13-17-39(18-14-36)50(47)29-37-27-42-30-45(37)20-6-2/h10-19,25-27,30-31H,5-9,20-24,28-29H2,1-4H3,(H,43,46)/b34-26+/t50-/m0/s1
InChi Key	PNDKCRDVVKJPKG-WHERJAGFSA-N
Canonical SMILES	CCCCOCCOC1=CC=C(C=C1)C2=CC3=C(C=C2)N(CCCC(=C3)C(=O)NC4=CC=C(C=C4)S(=O)CC5=CN=CN5CCC)CC(C)C
Isomeric SMILES	CCCCOCCOC1=CC=C(C=C1)C2=CC/3=C(C=C2)N(CCC/C(=C3)/C(=O)NC4=CC=C(C=C4)[S@@](=O)CC5=CN=CN5CCC)CC(C)C
PubChem CID	11285792
Molecular Weight	696.95

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4 results found

Lot Number	Certificate Type	Date	Item
G2213340	Certificate of Analysis	Jun 10, 2022	C176619
G2213490	Certificate of Analysis	Jun 10, 2022	C176619
G2213491	Certificate of Analysis	Jun 10, 2022	C176619
G2213510	Certificate of Analysis	Jun 10, 2022	C176619

References

1. Friedman SL, Ratziu V, Harrison SA, Abdelmalek MF, Aithal GP, Caballeria J, Francque S, Farrell G, Kowdley KV, Craxi A et al.. (2018) A randomized, placebo-controlled trial of cenicriviroc for treatment of nonalcoholic steatohepatitis with fibrosis.. Hepatology, 67 (5): (1754-1767). [PMID:28833331]

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