CEP 1347 - ≥97%(HPLC), high purity , CAS No.156177-65-0, Inhibitor of mitogen-activated protein kinase kinase kinase 10;Inhibitor of mitogen-activated protein kinase kinase kinase 11;Inhibitor of mitogen-activated protein kinase kinase kinase 12;Inhibitor of mitogen-activated protein kinase kinase kinase 9
CEP 1347 - ≥97%(HPLC), high purity , CAS No.156177-65-0, Inhibitor of mitogen-activated protein kinase kinase kinase 10;Inhibitor of mitogen-activated protein kinase kinase kinase 11;Inhibitor of mitogen-activated protein kinase kinase kinase 12;Inhibitor of mitogen-activated protein kinase kinase kinase 9
Inhibitor of c-jun N-terminal kinase (JNK) signaling. Rescues motor neurons undergoing apoptosis (EC50= 20 nM). Blocks Aβ-induced cortical neuron apoptosis (EC50~51 nM). Does not inhibit ERK1 activity. Neuroprotective.
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
INHIBITOR
Mechanism of action
Inhibitor of mitogen-activated protein kinase kinase kinase 10;Inhibitor of mitogen-activated protein kinase kinase kinase 11;Inhibitor of mitogen-activated protein kinase kinase kinase 12;Inhibitor of mitogen-activated protein kinase kinase kinase 9
1.Conforti P, Ramos C, Apostol BL, Simmons DA, Nguyen HP, Riess O, Thompson LM, Zuccato C, Cattaneo E. (2008) Blood level of brain-derived neurotrophic factor mRNA is progressively reduced in rodent models of Huntington's disease: restoration by the neuroprotective compound CEP-1347.. Mol Cell Neurosci, 39 (1):(1-7). [PMID:18571429]
2.Apostol BL, Simmons DA, Zuccato C, Illes K, Pallos J, Casale M, Conforti P, Ramos C, Roarke M, Kathuria S et al.. (2008) CEP-1347 reduces mutant huntingtin-associated neurotoxicity and restores BDNF levels in R6/2 mice.. Mol Cell Neurosci, 39 (1):(8-20). [PMID:18602275]
3.Pirvola U, Xing-Qun L, Virkkala J, Saarma M, Murakata C, Camoratto AM, Walton KM, Ylikoski J. (2000) Rescue of hearing, auditory hair cells, and neurons by CEP-1347/KT7515, an inhibitor of c-Jun N-terminal kinase activation.. J Neurosci, 20 (1):(43-50). [PMID:10627579]
4.Maroney AC, Finn JP, Connors TJ, Durkin JT, Angeles T, Gessner G, Xu Z, Meyer SL, Savage MJ, Greene LA et al.. (2001) Cep-1347 (KT7515), a semisynthetic inhibitor of the mixed lineage kinase family.. J Biol Chem, 276 (27):(25302-8). [PMID:11325962]
5.Harris CA, Deshmukh M, Tsui-Pierchala B, Maroney AC, Johnson Jr EM. (2002) Inhibition of the c-Jun N-terminal kinase signaling pathway by the mixed lineage kinase inhibitor CEP-1347 (KT7515) preserves metabolism and growth of trophic factor-deprived neurons.. J Neurosci, 22 (1):(103-13). [PMID:11756493]
6.Parkinson Study Group PRECEPT Investigators. (2007) Mixed lineage kinase inhibitor CEP-1347 fails to delay disability in early Parkinson disease.. Neurology, 69 (15):(1480-90). [PMID:17881719]
7.Saporito MS, Brown EM, Miller MS, Carswell S. (1999) CEP-1347/KT-7515, an inhibitor of c-jun N-terminal kinase activation, attenuates the 1-methyl-4-phenyl tetrahydropyridine-mediated loss of nigrostriatal dopaminergic neurons In vivo.. J Pharmacol Exp Ther, 288 (2):(421-7). [PMID:9918541]
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