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Cervonic Acid - ≥98%, high purity , CAS No.6217-54-5, Agonist of FFA1 receptor;Activator of K 2P10.1;Agonist of Retinoid X receptor-α;Activator of TRPA1

  • Moligand™
  • ≥98%
Item Number
D100925
Grouped product items
SKUSizeAvailabilityPrice Qty
D100925-100mg
100mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$58.90
D100925-500mg
500mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$189.90
D100925-1g
1g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$342.90
D100925-5g
5g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$1,539.90
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RXR agonist

View related series
FFA1 receptor Agonist K2P10.1 Activator Retinoid X receptor-α Agonist TRPA1 Activator

Basic Description

SynonymsDocosahexaenoic acid|Doconexent|Cervonic acid|6217-54-5|cis-4,7,10,13,16,19-Docosahexaenoic acid|Docosahexaenoate|Doconexentum|Doconexento|Doxonexent|all-cis-DHA|AquaGrow Advantage|Martek DHA HM|Ropufa 60|(4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hex
Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological MechanismsEndogenous omega-3 fatty acid. Acts as a selective retinoid X receptor (RXR) agonist that displays no activity at RAR, thyroid hormone receptor or the vitamin D receptor (VDR). Activates all three RXR isoforms. Also shown to inhibit Aβ1-42 fibrillation an
Storage TempStore at -20°C,Argon charged
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeACTIVATOR, AGONIST
Mechanism of actionAgonist of FFA1 receptor;Activator of K 2P10.1;Agonist of Retinoid X receptor-α;Activator of TRPA1
Product Description

DHA is an essential fatty acid and the most abundant ω-3 fatty acid in neural tissues, especially in the retina and brain. DHA constitutes as much as 40% of the total PUFA pool in retinal and neuronal membranes. Supplementation of dietary DHA using fish oil inhibits the progression of atherosclerosis and delays photoreceptor degeneration in retinitis pigmentosa. Neonatal DHA deprivation causes developmental defects and can lead to hypertension in rats.
Docosahexaenoic acid, DHA, is an omega-3 polyunsaturated fatty acid with 22 carbons and six double bonds, the first double bond occuring at position three from the methyl terminus (22:6 n-3). DHA is a component of lipid membranes and the myelin sheath. DHA also serves as a precursor for signaling molecules such as prostaglandins and eicosanoids.

Associated Targets

CFTR Tclin Cystic fibrosis transmembrane conductance regulator 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

EHMT2 Tchem Histone-lysine N-methyltransferase EHMT2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

POLL Tbio DNA polymerase lambda 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GMNN Tbio Geminin 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PSMB11 Tbio Proteasome subunit beta type-11 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

RUNX1 Tbio Runt-related transcription factor 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

VDR Tclin Vitamin D3 receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

FFAR1 Tchem Free fatty acid receptor 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

FAAH Tchem Fatty-acid amide hydrolase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

RXRA Tclin Retinoic acid receptor RXR-alpha 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TRPA1 Tclin Transient receptor potential cation channel subfamily A member 1 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

POLK Tbio DNA polymerase kappa 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

RBP4 Tchem Retinol-binding protein 4 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PTGS1 Tclin Prostaglandin G/H synthase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PTGS2 Tclin Prostaglandin G/H synthase 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

NR4A1 Tchem Nuclear receptor subfamily 4 group A member 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

NR4A2 Tchem Nuclear receptor subfamily 4 group A member 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CYP19A1 Tclin Aromatase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ALDH1A1 Tchem Retinal dehydrogenase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

MAPT Tclin Microtubule-associated protein tau 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

KCNK10 Tclin Potassium channel subfamily K member 10 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

IMPA1 Tclin Inositol monophosphatase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GLS Tchem Glutaminase kidney isoform, mitochondrial 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

OXER1 Tchem Oxoeicosanoid receptor 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PPARG Tclin Peroxisome proliferator-activated receptor gamma 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name (4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoic acid
INCHI InChI=1S/C22H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h3-4,6-7,9-10,12-13,15-16,18-19H,2,5,8,11,14,17,20-21H2,1H3,(H,23,24)/b4-3-,7-6-,10-9-,13-12-,16-15-,19-18-
InChi Key MBMBGCFOFBJSGT-KUBAVDMBSA-N
Canonical SMILES CCC=CCC=CCC=CCC=CCC=CCC=CCCC(=O)O
Isomeric SMILES CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O
WGK Germany 3
PubChem CID 445580
Molecular Weight 328.49

Certificates

Certificate of Analysis(COA)

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13 results found

Lot NumberCertificate TypeDateItem
H2415059Certificate of AnalysisAug 31, 2024 D100925
C2408002Certificate of AnalysisMar 26, 2024 D100925
J2226355Certificate of AnalysisDec 11, 2023 D100925
G2322269Certificate of AnalysisDec 11, 2023 D100925
G2322275Certificate of AnalysisDec 11, 2023 D100925
G2322277Certificate of AnalysisDec 11, 2023 D100925
G2322280Certificate of AnalysisDec 11, 2023 D100925
C2330385Certificate of AnalysisApr 10, 2023 D100925
D2313853Certificate of AnalysisApr 10, 2023 D100925
D2313859Certificate of AnalysisApr 10, 2023 D100925
J2226353Certificate of AnalysisMar 07, 2023 D100925
J2226354Certificate of AnalysisMar 07, 2023 D100925
J2226356Certificate of AnalysisMar 07, 2023 D100925

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Chemical and Physical Properties

SolubilitySolvent:DMSO, Max Conc. mg/mL: 32.85, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 32.85, Max Conc. mM: 100
SensitivityAir & Light & Heat sensitive
Refractive Index1.5049
Flash Point(°C)62℃
Melt Point(°C)-44.5--44.1°C

Safety and Hazards(GHS)

WGK Germany 3
Merck Index 3398

Related Documents

 SDS

 Specification Sheet

Alternative Products

  1. Cervonic Acid - 10mM in DMSO, used for , CAS No. 6217-54-5, by Aladdin Scientific
    Cervonic Acid

    Starting at $100.90

References

1. Hossain S, Hashimoto M, Katakura M, Miwa K, Shimada T, Shido O.  (2009)  Mechanism of docosahexaenoic acid-induced inhibition of in vitro Abeta1-42 fibrillation and Abeta1-42-induced toxicity in SH-S5Y5 cells..  J Neurochem,  111  (2): (568-79).  [PMID:19686246]
2. Hoffman DR, Hughbanks-Wheaton DK, Pearson NS, Fish GE, Spencer R, Takacs A, Klein M, Locke KG, Birch DG.  (2014)  Four-year placebo-controlled trial of docosahexaenoic acid in X-linked retinitis pigmentosa (DHAX trial): a randomized clinical trial..  JAMA Ophthalmol,  132  (7): (866-73).  [PMID:24805262]
3. M Martínez.  (1990-08-01)  Severe deficiency of docosahexaenoic acid in peroxisomal disorders: a defect of delta 4 desaturation?.  Neurology,  40  ((8)): (1292-1298).  [PMID:2143272]
4. C Löser,U R Fölsch,C Paprotny,W Creutzfeldt.  (1990-03-01)  Polyamine concentrations in pancreatic tissue, serum, and urine of patients with pancreatic cancer..  Pancreas,  5  ((2)): (119-127).  [PMID:2315288]
5. T Shingu,J W Karanian,H Y Kim,J A Yergey,N Salem.  (1988-01-01)  Discovery of novel brain lipoxygenase products formed from docosahexaenoic acid (22:6w3)..  Advances in alcohol & substance abuse,  7  ((3-4)): (235-240).  [PMID:2975919]
6. R Andrew,S A Best,D G Watson,J M Midgley,J L Reid,I B Squire.  (1993-11-01)  Analysis of biogenic amines in plasma of hypertensive patients and a control group..  Neurochemical research,  18  ((11)): (1179-1182).  [PMID:8255371]
7. A Watanabe,S Saito,T Tsuchida,K Higuchi,M Okita.  (1999-05-13)  Low plasma levels of docosahexaenoic acid in patients with liver cirrhosis and its correction with a polyunsaturated fatty acid-enriched soft oil capsule..  Nutrition (Burbank, Los Angeles County, Calif.),  15  ((4)): (284-288).  [PMID:10319360]
8. Rima Obeid,Mariz Kasoha,Jean-Pierre Knapp,Panagiotis Kostopoulos,George Becker,Klaus Fassbender,Wolfgang Herrmann.  (2007-03-27)  Folate and methylation status in relation to phosphorylated tau protein(181P) and beta-amyloid(1-42) in cerebrospinal fluid..  Clinical chemistry,  53  ((6)): (1129-1136).  [PMID:17384003]
9. Masahiko Yano,Masanori Ikeda,Ken-Ichi Abe,Hiromichi Dansako,Shogo Ohkoshi,Yutaka Aoyagi,Nobuyuki Kato.  (2007-04-11)  Comprehensive analysis of the effects of ordinary nutrients on hepatitis C virus RNA replication in cell culture..  Antimicrobial agents and chemotherapy,  51  ((6)): (2016-2027).  [PMID:17420205]
10. L G Darlington,G M Mackay,C M Forrest,N Stoy,C George,T W Stone.  (2007-09-26)  Altered kynurenine metabolism correlates with infarct volume in stroke..  The European journal of neuroscience,  26  ((8)): (2211-2221).  [PMID:17892481]
11. Denis Fourches,Julie C Barnes,Nicola C Day,Paul Bradley,Jane Z Reed,Alexander Tropsha.  (2009-12-18)  Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species..  Chemical research in toxicology,  23  ((1)): (171-183).  [PMID:20014752]
12. Kevin A Harvey,Zhidong Xu,Phillip Whitley,V Jo Davisson,Rafat A Siddiqui.  (2010-02-16)  Characterization of anticancer properties of 2,6-diisopropylphenol-docosahexaenoate and analogues in breast cancer cells..  Bioorganic & medicinal chemistry,  18  ((5)): (1866-1874).  [PMID:20153203]
13. N P Hessvik,S S Bakke,K Fredriksson,M V Boekschoten,A Fjørkenstad,G Koster,M K Hesselink,S Kersten,E T Kase,A C Rustan,G H Thoresen.  (2010-04-07)  Metabolic switching of human myotubes is improved by n-3 fatty acids..  Journal of lipid research,  51  ((8)): (2090-2104).  [PMID:20363834]
14. Oswald Quehenberger,Aaron M Armando,Alex H Brown,Stephen B Milne,David S Myers,Alfred H Merrill,Sibali Bandyopadhyay,Kristin N Jones,Samuel Kelly,Rebecca L Shaner,Cameron M Sullards,Elaine Wang,Robert C Murphy,Robert M Barkley,Thomas J Leiker,Christian R H Raetz,Ziqiang Guan,Gregory M Laird,David A Six,David W Russell,Jeffrey G McDonald,Shankar Subramaniam,Eoin Fahy,Edward A Dennis.  (2010-07-31)  Lipidomics reveals a remarkable diversity of lipids in human plasma..  Journal of lipid research,  51  ((11)): (3299-3305).  [PMID:20671299]
15. Eduardo Luiz Moreira,Jade de Oliveira,Márcio Ferreira Dutra,Danúbia Bonfanti Santos,Carlos Alberto Gonçalves,Eliane Maria Goldfeder,Andreza Fabro de Bem,Rui Daniel Prediger,Michael Aschner,Marcelo Farina.  (2012-08-21)  Does methylmercury-induced hypercholesterolemia play a causal role in its neurotoxicity and cardiovascular disease?.  Toxicological sciences : an official journal of the Society of Toxicology,  130  ((2)): (373-382).  [PMID:22903822]
16. Si-Ming Zhang,Kristen A Coultas.  (2013-05-04)  Identification of plumbagin and sanguinarine as effective chemotherapeutic agents for treatment of schistosomiasis..  International journal for parasitology. Drugs and drug resistance,  3  (28-34).  [PMID:23641325]
17. Sarah K Orr,Sara Palumbo,Francesca Bosetti,Howard T Mount,Jing X Kang,Carol E Greenwood,David W L Ma,Charles N Serhan,Richard P Bazinet.  (2013-08-08)  Unesterified docosahexaenoic acid is protective in neuroinflammation..  Journal of neurochemistry,  127  ((3)): (378-393).  [PMID:23919613]
18. Ana Pagán,María T Prieto-Sánchez,José E Blanco-Carnero,Alfonso Gil-Sánchez,Juan J Parrilla,Hans Demmelmair,Berthold Koletzko,Elvira Larqué.  (2013-08-08)  Materno-fetal transfer of docosahexaenoic acid is impaired by gestational diabetes mellitus..  American journal of physiology. Endocrinology and metabolism,  305  ((7)): (E826-E833).  [PMID:23921142]
19. Rodrigo Marcon,Allisson F Bento,Rafael C Dutra,Maira A Bicca,Daniela F P Leite,João B Calixto.  (2013-09-17)  Maresin 1, a proresolving lipid mediator derived from omega-3 polyunsaturated fatty acids, exerts protective actions in murine models of colitis..  Journal of immunology (Baltimore, Md. : 1950),  191  ((8)): (4288-4298).  [PMID:24038091]
20. Ryan G Snodgrass,Shurong Huang,Il-Whan Choi,John C Rutledge,Daniel H Hwang.  (2013-09-18)  Inflammasome-mediated secretion of IL-1β in human monocytes through TLR2 activation; modulation by dietary fatty acids..  Journal of immunology (Baltimore, Md. : 1950),  191  ((8)): (4337-4347).  [PMID:24043885]
21. Jonathan Giovannelli,Jean Dallongeville,Aline Wagner,Vanina Bongard,Brigitte Laillet,Nadine Marecaux,Jean Bernard Ruidavets,Bernadette Haas,Jean Ferrieres,Dominique Arveiler,Chantal Simon,Luc Dauchet.  (2013-10-03)  Validation of a short, qualitative food frequency questionnaire in French adults participating in the MONA LISA-NUT study 2005-2007..  Journal of the Academy of Nutrition and Dietetics,  114  ((4)): (552-561).  [PMID:24083967]
22. Andrew A Bremer,Kimber L Stanhope,James L Graham,Bethany P Cummings,Steve B Ampah,Benjamin R Saville,Peter J Havel.  (2013-10-11)  Fish oil supplementation ameliorates fructose-induced hypertriglyceridemia and insulin resistance in adult male rhesus macaques..  The Journal of nutrition,  144  ((1)): (5-11).  [PMID:24108131]
23. Jingyu Xu,Michael Kazachkov,Yunhua Jia,Zhifu Zheng,Jitao Zou.  (2013-10-17)  Expression of a type 2 diacylglycerol acyltransferase from Thalassiosira pseudonana in yeast leads to incorporation of docosahexaenoic acid β-oxidation intermediates into triacylglycerol..  The FEBS journal,  280  ((23)): (6162-6172).  [PMID:24128189]
24. Miki Eto,Hideo Shindou,Takao Shimizu.  (2013-12-18)  A novel lysophosphatidic acid acyltransferase enzyme (LPAAT4) with a possible role for incorporating docosahexaenoic acid into brain glycerophospholipids..  Biochemical and biophysical research communications,  443  ((2)): (718-724).  [PMID:24333445]
25. Milène Vandal,Wael Alata,Cyntia Tremblay,Christine Rioux-Perreault,Norman Salem,Frédéric Calon,Mélanie Plourde.  (2013-12-19)  Reduction in DHA transport to the brain of mice expressing human APOE4 compared to APOE2..  Journal of neurochemistry,  129  ((3)): (516-526).  [PMID:24345162]
26. Ester Casanova,Laura Baselga-Escudero,Aleix Ribas-Latre,Anna Arola-Arnal,Cinta Bladé,Lluís Arola,M Josepa Salvadó.  (2014-02-04)  Epigallocatechin gallate counteracts oxidative stress in docosahexaenoxic acid-treated myocytes..  Biochimica et biophysica acta,  1837  ((6)): (783-791).  [PMID:24486445]
27. Chiara Cipollina,Serena Di Vincenzo,Stefania Gerbino,Liboria Siena,Mark Gjomarkaj,Elisabetta Pace.  (2014-03-07)  Dual anti-oxidant and anti-inflammatory actions of the electrophilic cyclooxygenase-2-derived 17-oxo-DHA in lipopolysaccharide- and cigarette smoke-induced inflammation..  Biochimica et biophysica acta,  1840  ((7)): (2299-2309).  [PMID:24594225]
28. Lucy M Browning,Celia G Walker,Adrian P Mander,Annette L West,Joanna Gambell,Jackie Madden,Philip C Calder,Susan A Jebb.  (2014-03-22)  Compared with daily, weekly n-3 PUFA intake affects the incorporation of eicosapentaenoic acid and docosahexaenoic acid into platelets and mononuclear cells in humans..  The Journal of nutrition,  144  ((5)): (667-672).  [PMID:24647395]
29. Antonio Recchiuti,Marilina Codagnone,Anna Maria Pierdomenico,Cosmo Rossi,Veronica Cecilia Mari,Eleonora Cianci,Felice Simiele,Valentina Gatta,Mario Romano.  (2014-04-03)  Immunoresolving actions of oral resolvin D1 include selective regulation of the transcription machinery in resolution-phase mouse macrophages..  FASEB journal : official publication of the Federation of American Societies for Experimental Biology,  28  ((7)): (3090-3102).  [PMID:24692596]
30. Romain A Colas,Masakazu Shinohara,Jesmond Dalli,Nan Chiang,Charles N Serhan.  (2014-04-04)  Identification and signature profiles for pro-resolving and inflammatory lipid mediators in human tissue..  American journal of physiology. Cell physiology,  307  ((1)): (C39-C54).  [PMID:24696140]
31. Christer Betsholtz.  (2014-05-16)  Physiology: Double function at the blood-brain barrier..  Nature,  509  ((7501)): (432-433).  [PMID:24828036]
32. Helen N Saada,Ussama Z Said,Elsayed M E Mahdy,Hattem E Elmezayen,Shereen M Shedid.  (2014-06-18)  Fish oil omega-3 fatty acids reduce the severity of radiation-induced oxidative stress in the rat brain..  International journal of radiation biology,  90  ((12)): (1179-1183).  [PMID:24937371]
33. Song Hong,Haibin Tian,Yan Lu,James Monroe Laborde,Filipe A Muhale,Quansheng Wang,Bhagwat V Alapure,Charles N Serhan,Nicolas G Bazan.  (2014-10-03)  Neuroprotectin/protectin D1: endogenous biosynthesis and actions on diabetic macrophages in promoting wound healing and innervation impaired by diabetes..  American journal of physiology. Cell physiology,  307  ((11)): (C1058-C1067).  [PMID:25273880]
34. Anne Létondor,Benjamin Buaud,Carole Vaysse,Laurence Fonseca,Coralie Herrouin,Benjamin Servat,Sophie Layé,Véronique Pallet,Serge Alfos.  (2014-10-22)  Erythrocyte DHA level as a biomarker of DHA status in specific brain regions of n-3 long-chain PUFA-supplemented aged rats..  The British journal of nutrition,  112  ((11)): (1805-1818).  [PMID:25331622]
35. Hannah E Smith,Kelsey N Ryan,Kevin B Stephenson,Claire Westcott,Chrissie Thakwalakwa,Ken Maleta,Jacqueline Y Cheng,J Thomas Brenna,Robert J Shulman,Indi Trehan,Mark J Manary.  (2014-11-21)  Multiple micronutrient supplementation transiently ameliorates environmental enteropathy in Malawian children aged 12-35 months in a randomized controlled clinical trial..  The Journal of nutrition,  144  ((12)): (2059-2065).  [PMID:25411039]
36. Raphaëlle Varraso,R Graham Barr,Walter C Willett,Frank E Speizer,Carlos A Camargo.  (2015-02-04)  Fish intake and risk of chronic obstructive pulmonary disease in 2 large US cohorts..  The American journal of clinical nutrition,  101  ((2)): (354-361).  [PMID:25646333]
37. Guang Yang,Zhen Ren,Yan-Ai Mei.  (2015-07-16)  Exposure to 50 Hz magnetic field modulates GABAA currents in cerebellar granule neurons through an EP receptor-mediated PKC pathway..  Journal of cellular and molecular medicine,  19  ((10)): (2413-2422).  [PMID:26176998]
38. Mohsen Rokni,Ali Reza Razavi,Fazel Shokri,Kazem Ahmadi Kia,Farid Solaymani-Mohammadi,Reza Chahardoli,Ali Akbar Saboor-Yaraghi.  (2018-04-21)  Enhancement of monoclonal antibody production after single and combination treatment of the hybridoma cells with all-trans retinoic acid and docosahexaenoic acid: An in vitro and in vivo study..  International immunopharmacology,  59  (295-300).  [PMID:29677631]
39. Zhiping Ren,Lin Chen,Yimeng Wang,Xinbing Wei,Shenglan Zeng,Yi Zheng,Chengjiang Gao,Huiqing Liu.  (2019-01-02)  Activation of the Omega-3 Fatty Acid Receptor GPR120 Protects against Focal Cerebral Ischemic Injury by Preventing Inflammation and Apoptosis in Mice..  Journal of immunology (Baltimore, Md. : 1950),  202  ((3)): (747-759).  [PMID:30598514]
40. Yasukazu Takanezawa,Ryosuke Nakamura,Miho Hamaguchi,Kanae Yamamoto,Yuka Sone,Shimpei Uraguchi,Masako Kiyono.  (2019-02-16)  Docosahexaenoic acid enhances methylmercury-induced endoplasmic reticulum stress and cell death and eicosapentaenoic acid potentially attenuates these effects in mouse embryonic fibroblasts..  Toxicology letters,  306  (35-42).  [PMID:30769081]
41. Xiaobo Li,Jian Cui,Hongbao Yang,Hao Sun,Runze Lu,Na Gao,Qingtao Meng,Shenshen Wu,Jiong Wu,Michael Aschner,Rui Chen.  (2019-06-11)  Colonic Injuries Induced by Inhalational Exposure to Particulate-Matter Air Pollution..  Advanced science (Weinheim, Baden-Wurttemberg, Germany),  6  ((11)): (1900180-1900180).  [PMID:31179224]
42. Yuanji Ma,Fang Chen,Yan Xu,Ming Wang,Taoyou Zhou,Jiajie Lu,Ping Feng,Ying Wang,Lang Bai,Hong Tang.  (2019-06-20)  Safety and Efficacy of Regional Citrate Anticoagulation during Plasma Adsorption Plus Plasma Exchange Therapy for Patients with Acute-on-Chronic Liver Failure: A Pilot Study..  Blood purification,  48  ((3)): (223-232).  [PMID:31216551]
43. Wei Zhu,Guangqiang Cui,Tuo Li,Hongguang Chen,Jian Zhu,Yuexia Ding,Li Zhao.  (2020-07-18)  Docosahexaenoic Acid Protects Traumatic Brain Injury by Regulating NOX2 Generation via Nrf2 Signaling Pathway..  Neurochemical research,  45  ((8)): (1839-1850).  [PMID:32676950]
44. Shuta Nagata,Kaoru Tatematsu,Hitoki Yamaguchi,Yuki Inoue,Keisuke Tanaka,Hidetaka Tasaki,Koumei Shirasuna,Hisataka Iwata.  (2021-10-15)  Effect of docosahexaenoic acid on in vitro growth of bovine oocytes..  Reproductive medicine and biology,  20  ((4)): (485-493).  [PMID:34646077]
45. Pooranee K Morgan, Kevin Huynh, Gerard Pernes, Paula M Miotto, Natalie A Mellett, Corey Giles, Peter J Meikle, Andrew J Murphy, Graeme I Lancaster,.  (2021-10-26)  Macrophage polarization state affects lipid composition and the channeling of exogenous fatty acids into endogenous lipid pools..  The Journal of biological chemistry,  297  ((6)): ( 101341-101341 ).  [PMID:34695418]
46. T A Sanders.  (2000-01-05)  Polyunsaturated fatty acids in the food chain in Europe..  The American journal of clinical nutrition,  71  ((1 Suppl)): (176S-178S).  [PMID:10617968]
47. Ignacio A Gómez de Segura,Santiago Valderrábano,Isabel Vázquez,María T Vallejo-Cremades,Lourdes Gómez-García,Miriam Sánchez,Enrique de Miguel.  (2004-04-21)  Protective effects of dietary enrichment with docosahexaenoic acid plus protein in 5-fluorouracil-induced intestinal injury in the rat..  European journal of gastroenterology & hepatology,  16  ((5)): (479-485).  [PMID:15097041]
48. Walter J Lukiw,Jian-Guo Cui,Victor L Marcheselli,Merete Bodker,Anja Botkjaer,Katherine Gotlinger,Charles N Serhan,Nicolas G Bazan.  (2005-09-10)  A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease..  The Journal of clinical investigation,  115  ((10)): (2774-2783).  [PMID:16151530]
49. Song Hong,Eric Tjonahen,Elizabeth L Morgan,Yan Lu,Charles N Serhan,Andrew F Rowley.  (2005-11-24)  Rainbow trout (Oncorhynchus mykiss) brain cells biosynthesize novel docosahexaenoic acid-derived resolvins and protectins-Mediator lipidomic analysis..  Prostaglandins & other lipid mediators,  78  ((1-4)): (107-116).  [PMID:16303609]
50. Takahiro Yamashita,Yoichi Nakao,Shigeki Matsunaga,Tsutomu Oikawa,Yukimitsu Imahara,Nobuhiro Fusetani.  (2008-11-28)  A new antiangiogenic C24 oxylipin from the soft coral Sinularia numerosa..  Bioorganic & medicinal chemistry,  17  ((6)): (2181-2184).  [PMID:19036594]
51. Suresh Awale,Chihiro Tohda,Yasuhiro Tezuka,Makoto Miyazaki,Shigetoshi Kadota.  (2009-10-01)  Protective Effects of Rosa damascena and Its Active Constituent on Aβ(25-35)-Induced Neuritic Atrophy..  Evidence-based complementary and alternative medicine : eCAM,  2011  (131042-131042).  [PMID:19789212]
52. Philippe de Medina,Michael R Paillasse,Bruno Payré,Sandrine Silvente-Poirot,Marc Poirot.  (2009-10-14)  Synthesis of new alkylaminooxysterols with potent cell differentiating activities: identification of leads for the treatment of cancer and neurodegenerative diseases..  Journal of medicinal chemistry,  52  ((23)): (7765-7777).  [PMID:19821610]
53. Kajana Satkunendrarajah,Michael G Fehlings.  (2013-09-03)  Do omega-3 polyunsaturated fatty acids ameliorate spinal cord injury?: Commentary on: Lim et al., Improved outcome after spinal cord compression injury in mice treated with docosahexaeonic acid. Exp. Neurol. Jan; 239:13-27..  Experimental neurology,  249  (104-110).  [PMID:23994716]
54. Yulan Liu,Feng Chen,Quan Li,Jack Odle,Xi Lin,Huiling Zhu,Dingan Pi,Yongqing Hou,Yu Hong,Haifeng Shi.  (2013-09-06)  Fish oil alleviates activation of the hypothalamic-pituitary-adrenal axis associated with inhibition of TLR4 and NOD signaling pathways in weaned piglets after a lipopolysaccharide challenge..  The Journal of nutrition,  143  ((11)): (1799-1807).  [PMID:24005609]
55. Eric M Ammann,James V Pottala,William S Harris,Mark A Espeland,Robert Wallace,Natalie L Denburg,Ryan M Carnahan,Jennifer G Robinson.  (2013-09-27)  ω-3 fatty acids and domain-specific cognitive aging: secondary analyses of data from WHISCA..  Neurology,  81  ((17)): (1484-1491).  [PMID:24068783]
56. William S Harris,Thomas D Dayspring,Terrance J Moran.  (2013-11-10)  Omega-3 fatty acids and cardiovascular disease: new developments and applications..  Postgraduate medicine,  125  ((6)): (100-113).  [PMID:24200766]
57. Yongsheng Li,Jesmond Dalli,Nan Chiang,Rebecca M Baron,Carolina Quintana,Charles N Serhan.  (2013-11-19)  Plasticity of leukocytic exudates in resolving acute inflammation is regulated by MicroRNA and proresolving mediators..  Immunity,  39  ((5)): (885-898).  [PMID:24238341]
58. Clark D Russell,Jürgen Schwarze.  (2014-01-10)  The role of pro-resolution lipid mediators in infectious disease..  Immunology,  141  ((2)): (166-173).  [PMID:24400794]
59. Maria Makrides,Jacqueline F Gould,Nicola R Gawlik,Lisa N Yelland,Lisa G Smithers,Peter J Anderson,Robert A Gibson.  (2014-05-06)  Four-year follow-up of children born to women in a randomized trial of prenatal DHA supplementation..  JAMA,  311  ((17)): (1802-1804).  [PMID:24794375]
60. Huifang Tang,Yanlan Liu,Chunguang Yan,Nicos A Petasis,Charles N Serhan,Hongwei Gao.  (2014-08-31)  Protective actions of aspirin-triggered (17R) resolvin D1 and its analogue, 17R-hydroxy-19-para-fluorophenoxy-resolvin D1 methyl ester, in C5a-dependent IgG immune complex-induced inflammation and lung injury..  Journal of immunology (Baltimore, Md. : 1950),  193  ((7)): (3769-3778).  [PMID:25172497]
61. Lieke W J van den Elsen,Marianne Bol-Schoenmakers,Betty C A M van Esch,Gerard A Hofman,Bert J M van de Heijning,Raymond H Pieters,Joost J Smit,Johan Garssen,Linette E M Willemsen.  (2014-10-25)  DHA-rich tuna oil effectively suppresses allergic symptoms in mice allergic to whey or peanut..  The Journal of nutrition,  144  ((12)): (1970-1976).  [PMID:25342698]
62. Ping K Yip,Amy L Bowes,Jodie C E Hall,Miguel A Burguillos,T H Richard Ip,Tracey Baskerville,Zhuo-Hao Liu,Moumin A E K Mohamed,Fanuelle Getachew,Anna D Lindsay,Saif-Ur-Rehman Najeeb,Phillip G Popovich,John V Priestley,Adina T Michael-Titus.  (2019-04-12)  Docosahexaenoic acid reduces microglia phagocytic activity via miR-124 and induces neuroprotection in rodent models of spinal cord contusion injury..  Human molecular genetics,  28  ((14)): (2427-2448).  [PMID:30972415]
63. Ya-Chao Jia,Shuo Qiu,Jia Xu,Qing-Lin Kang,Yi-Min Chai.  (2020-04-26)  Docosahexaenoic Acid Improves Diabetic Wound Healing in a Rat Model by Restoring Impaired Plasticity of Macrophage Progenitor Cells..  Plastic and reconstructive surgery,  145  ((5)): (942e-950e).  [PMID:32332536]

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