127910-31-0|Cgp 37849|Cgp-37849|(E)-2-amino-4-methyl-5-phosphonopent-3-enoic acid|CGP37849|3-Pentenoic acid, 2-amino-4-methyl-5-phosphono-, (3E)-|2-Amino-4-methyl-5-phosphono-3-pentenoic acid|76IND1BS43|(E)-(+/-)-2-Amino-4-methyl-5-phosphono-3-pentenoic a
Specifications & Purity
Moligand™, ≥99%
Biochemical and Physiological Mechanisms
Competitive NMDA receptor antagonist (K i = 35 nM for displacement of CPP binding in rat brain). Potent oral anticonvulsant activity in vivo .
Storage Temp
Store at 2-8°C,Desiccated
Shipped In
Wet ice
Grade
Moligand™
Action Type
ANTAGONIST
Mechanism of action
Antagonist of GluN2A;Antagonist of GluN2B;Antagonist of GluN2C;Antagonist of GluN2D
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
1.Homma R et al.. (2013) In vivo functional properties of juxtaglomerular neurons in the mouse olfactory bulb.. Front Neural Circuits, 7 (23). [PMID:23459031]
2.Du H et al.. (2013) Neuregulin-1 impairs the long-term depression of hippocampal inhibitory synapses by facilitating the degradation of endocannabinoid 2-AG.. J Neurosci, 33 (38):(15022-31). [PMID:24048832]
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