CGP 53353 - 98%, high purity , CAS No.145915-60-2, Inhibitor of protein kinase C beta

Item Number

C286585

• Synonyms: 145915-60-2|CGP-53353|CGP 53353|DAPH-7|CGP53353|5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE|DAPH 7|CHEMBL7939|5,6-Bis((4-fluorophenyl)amino)isoindoline-1,3-dione|1H-Isoindole-1,3(2H)-dione, 5,6-bis[(4-fluorophenyl)amino]-|1H-Isoindole-1,3(2H
• Specifications & Purity: Moligand™, ≥98%
• Biochemical and Physiological Mechanisms: Selective inhibitor of PKCβII (IC50values are 0.41 and 3.8μM for PKCβII and PKCβI respectively). Also inhibits prionogenic Sup35 fibrillization (IC50~ 3.4μM) and inhibitsde novoAβ42 assemblyin vitro.
• Storage Temp: Protected from light,Store at -20°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: INHIBITOR
• Mechanism of action: Inhibitor of protein kinase C beta

Product Description

Product Describtion:

CGP-53353 (DAPH-7) is an potent PKC inhibitor with IC50s of 0.41 mM and 3.8 mM for PKCβII and PKCβI, respectively. CGP-53353 can inhibit glucose-induced cell proliferation and DNA synthesis in AoSMC and A10 cells. CGP-53353 can be used for researching atherosclerosis of diabetic patients.

Ck 5,6-bis((4-fluorophenyl)amino)isoindoline-1,3-dione