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CGP 57380 - ≥98%, high purity , CAS No.522629-08-9, Inhibitor of MAPK interacting serine/threonine kinase 1;Inhibitor of MAPK interacting serine/threonine kinase 2

Specifications & Purity: ≥98%

CAS#: 522629-08-9
Formula: C₁₁H₉FN₆
Molecular Weight: 244.23
PubChem CID: 11644425

Item Number

C274776

Grouped product items
SKU	Size	Availability	Price
C274776-1mg	1mg	In stock	$25.90
C274776-5mg	5mg	In stock	$105.90
C274776-10mg	10mg	In stock	$175.90
C274776-25mg	25mg	In stock	$396.90
C274776-50mg	50mg	In stock	$725.90

MNK inhibitor

View related series

MAPK interacting serine/threonine kinase 1 Inhibitor MAPK interacting serine/threonine kinase 2 Inhibitor

Basic Description

Synonyms	CGP 57380\|522629-08-9\|CGP-57380\|MNK1 Inhibitor\|N3-(4-fluorophenyl)-1h-pyrazolo[3,4-d]pyrimidine-3,4-diamine\|3-N-(4-fluorophenyl)-2H-pyrazolo[3,4-d]pyrimidine-3,4-diamine\|CHEMBL1240885\|CGP57380\|SCHEMBL987991\|GTPL6010\|SCHEMBL16714452\|CHEBI:92749\|DTXSID50469
Specifications & Purity	≥98%
Storage Temp	Store at -20°C
Shipped In	Dry ice
Action Type	INHIBITOR
Mechanism of action	Inhibitor of MAPK interacting serine/threonine kinase 1;Inhibitor of MAPK interacting serine/threonine kinase 2

Associated Targets

MKNK2 Tchem MAP kinase-interacting serine/threonine-protein kinase 2 1 Activities

Discover Target: MKNK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MKNK1 Tchem MAP kinase-interacting serine/threonine-protein kinase 1 1 Activities

Discover Target: MKNK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	3-N-(4-fluorophenyl)-2H-pyrazolo[3,4-d]pyrimidine-3,4-diamine
INCHI	InChI=1S/C11H9FN6/c12-6-1-3-7(4-2-6)16-11-8-9(13)14-5-15-10(8)17-18-11/h1-5H,(H4,13,14,15,16,17,18)
InChi Key	UQPMANVRZYYQMD-UHFFFAOYSA-N
Canonical SMILES	C1=CC(=CC=C1NC2=C3C(=NC=NC3=NN2)N)F
Isomeric SMILES	C1=CC(=CC=C1NC2=C3C(=NC=NC3=NN2)N)F
PubChem CID	11644425
Molecular Weight	244.23

PubChem CID

11644425

ChEMBL Ligand

CHEMBL1240885

CAS Registry No.

522629-08-9

Certificates

Certificate of Analysis(COA)

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5 results found

Lot Number	Certificate Type	Date	Item
L2108468	Certificate of Analysis	Jun 14, 2023	C274776
L2109088	Certificate of Analysis	Jun 14, 2023	C274776
L2108467	Certificate of Analysis	Jun 14, 2023	C274776
L2109089	Certificate of Analysis	Jun 14, 2023	C274776
L2108466	Certificate of Analysis	Sep 13, 2022	C274776

Pictogram(s)

GHS07

Signal

Warning

Hazard Statements

H319

Precautionary Statements

P305+P351+P338,P280,P264+P265,P337+P317

References

1. Moore CE et al.. (2016) MNK1 and MNK2 mediate adverse effects of high-fat feeding in distinct ways.. Sci Rep, 6 (23476). [PMID:27087055]
2. Leong SY et al.. (2015) The role of Misshapen NCK-related kinase (MINK), a novel Ste20 family kinase, in the IRES-mediated protein translation of human enterovirus 71.. PLoS Pathog, 11 (3): (e1004686). [PMID:25747578]

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