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CH-223191 - 98%, high purity , CAS No.301326-22-7

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CH-223191 - 98%, high purity , CAS No.301326-22-7

1 Citations

≥98%

CAS#: 301326-22-7
Formula: C₁₉H₁₉N₅O
Molecular Weight: 333.39
MDL number: MFCD00377884
PubChem CID: 3091786

Item Number

C303374

Grouped product items
SKU	Size	Availability	Price
C303374-5mg	5mg	In stock	$70.90
C303374-25mg	25mg	In stock	$319.90
C303374-100mg	100mg	In stock	$614.90
C303374-250mg	250mg	In stock	$1,383.90

Potent aryl hydrocarbon receptor (AhR) antagonist

Basic Description

Synonyms	Q27280162 \| CBDivE_007629 \| EX-A771 \| 1H-Pyrazole-5-carboxamide, 1-methyl-N-(2-methyl-4-(2-(2-methylphenyl)diazenyl)phenyl)- \| BCP12814 \| 1-Methyl-N-(2-methyl-4-(o-tolyldiazenyl)phenyl)-1H-pyrazole-5-carboxamide \| 1-methyl-N-{2-methyl-4-[2-(2-methylphenyl
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Potent aryl hydrocarbon receptor (AhR) antagonist (IC50= 30 nM). Exhibits no AhR agonist-like activity (at concentrations up to 100μM). Inhibits 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-induced AhR-dependent transcriptionin vitroand reduces TCDD-induced
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads

Associated Targets(Human)

AHR Tclin Aryl hydrocarbon receptor (1071 Activities)

Discover Target: AHR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	2-methyl-N-[2-methyl-4-[(2-methylphenyl)diazenyl]phenyl]pyrazole-3-carboxamide
INCHI	InChI=1S/C19H19N5O/c1-13-6-4-5-7-17(13)23-22-15-8-9-16(14(2)12-15)21-19(25)18-10-11-20-24(18)3/h4-12H,1-3H3,(H,21,25)
InChi Key	LKTNEXPODAWWFM-UHFFFAOYSA-N
Canonical SMILES	CC1=CC=CC=C1N=NC2=CC(=C(C=C2)NC(=O)C3=CC=NN3C)C
Isomeric SMILES	CC1=CC=CC=C1N=NC2=CC(=C(C=C2)NC(=O)C3=CC=NN3C)C
PubChem CID	3091786
Molecular Weight	333.39

Certificates

Certificate of Analysis(COA)

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6 results found

Lot Number	Certificate Type	Date	Item
J2114264	Certificate of Analysis	Aug 09, 2024	C303374
H2216278	Certificate of Analysis	Aug 19, 2022	C303374
A2412070	Certificate of Analysis	Sep 01, 2021	C303374
D2306073	Certificate of Analysis	Sep 01, 2021	C303374
G2312031	Certificate of Analysis	Sep 01, 2021	C303374
L2314031	Certificate of Analysis	Sep 01, 2021	C303374

Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 33.34, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 3.33, Max Conc. mM: 10

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H302:Harmful if swallowed
Precautionary Statements	P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help.

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Yang Yang, Yue Tao, Xiaodong Yi, Guanyu Zhong, Yanyan Gu, Yunhe Cui, Ying Zhang. (2024) Crosstalk between aryl hydrocarbon receptor and Wnt/β-catenin signaling pathway: Possible culprit of di (2-ethylhexyl) phthalate-mediated cardiotoxicity in zebrafish larvae. SCIENCE OF THE TOTAL ENVIRONMENT, 907 (5): (167907). [PMID:37866606] [10.1016/j.scitotenv.2023.167907]

References

1. Yang Yang, Yue Tao, Xiaodong Yi, Guanyu Zhong, Yanyan Gu, Yunhe Cui, Ying Zhang. (2024) Crosstalk between aryl hydrocarbon receptor and Wnt/β-catenin signaling pathway: Possible culprit of di (2-ethylhexyl) phthalate-mediated cardiotoxicity in zebrafish larvae. SCIENCE OF THE TOTAL ENVIRONMENT, 907 (5): (167907). [PMID:37866606] [10.1016/j.scitotenv.2023.167907]

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