Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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C608519-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,334.90 | |
C608519-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $2,001.90 |
Synonyms | RO4987655 | 874101-00-5 | RO-4987655 | CH4987655 | CH-4987655 | 3,4-Difluoro-2-[(2-Fluoro-4-Iodophenyl)amino]-N-(2-Hydroxyethoxy)-5-[(3-Oxo-1,2-Oxazinan-2-Yl)methyl]benzamide | 3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-N-(2-hydroxyethoxy)-5-((3-oxomorpholino)methyl |
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Specifications & Purity | Moligand™ |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Inhibitor of mitogen-activated protein kinase kinase 1 |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)-5-[(3-oxooxazinan-2-yl)methyl]benzamide |
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INCHI | InChI=1S/C20H19F3IN3O5/c21-14-9-12(24)3-4-15(14)25-19-13(20(30)26-31-7-5-28)8-11(17(22)18(19)23)10-27-16(29)2-1-6-32-27/h3-4,8-9,25,28H,1-2,5-7,10H2,(H,26,30) |
InChi Key | FIMYFEGKMOCQKT-UHFFFAOYSA-N |
Canonical SMILES | OCCONC(=O)c1cc(CN2OCCCC2=O)c(c(c1Nc1ccc(cc1F)I)F)F |
Isomeric SMILES | C1CC(=O)N(OC1)CC2=CC(=C(C(=C2F)F)NC3=C(C=C(C=C3)I)F)C(=O)NOCCO |
PubChem CID | 11548630 |
PubChem CID | 11548630 |
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ChEMBL Ligand | CHEMBL1614766 |
BindingDB Ligand | 50338038 |
DrugBank Ligand | DB12933 |
RCSB PDB Ligand | 3OR |
Enter Lot Number to search for COA:
1. Isshiki Y, Kohchi Y, Iikura H, Matsubara Y, Asoh K, Murata T, Kohchi M, Mizuguchi E, Tsujii S, Hattori K et al.. (2011) Design and synthesis of novel allosteric MEK inhibitor CH4987655 as an orally available anticancer agent.. Bioorg Med Chem Lett, 21 (6): (1795-801). [PMID:21316218] [10.1021/op500134e] |
2. Leijen S, Middleton MR, Tresca P, Kraeber-Bodéré F, Dieras V, Scheulen ME, Gupta A, Lopez-Valverde V, Xu ZX, Rueger R et al.. (2012) Phase I dose-escalation study of the safety, pharmacokinetics, and pharmacodynamics of the MEK inhibitor RO4987655 (CH4987655) in patients with advanced solid tumors.. Clin Cancer Res, 18 (17): (4794-805). [PMID:22767668] [10.1021/op500134e] |
3. Zimmer L, Barlesi F, Martinez-Garcia M, Dieras V, Schellens JH, Spano JP, Middleton MR, Calvo E, Paz-Ares L, Larkin J et al.. (2014) Phase I expansion and pharmacodynamic study of the oral MEK inhibitor RO4987655 (CH4987655) in selected patients with advanced cancer with RAS-RAF mutations.. Clin Cancer Res, 20 (16): (4251-61). [PMID:24947927] [10.1021/op500134e] |
4. Nakamichi S, Nokihara H, Yamamoto N, Yamada Y, Fujiwara Y, Tamura Y, Wakui H, Honda K, Mizugaki H, Kitazono S et al.. (2015) Phase I and pharmacokinetics/pharmacodynamics study of the MEK inhibitor RO4987655 in Japanese patients with advanced solid tumors.. Invest New Drugs, 33 (3): (641-51). [PMID:25809858] [10.1021/op500134e] |
5. Akinleye A, Furqan M, Mukhi N, Ravella P, Liu D. (2013) MEK and the inhibitors: from bench to bedside.. J Hematol Oncol, 6 (13): (27). [PMID:23587417] [10.1021/op500134e] |