CH5183284 (Debio-1347) - 99%, high purity , Fibroblast growth factor receptor 1 inhibitor, CAS No.1265229-25-1, Fibroblast growth factor receptor 1 inhibitor

Item Number

C302315

Grouped product items
SKU	Size	Availability	Price
C302315-5mg	5mg	Available within 1-2 weeks(?) Item is derived from our semi-finished stock and is processed in 1-2 weeks.	$48.90
C302315-10mg	10mg	In stock	$88.90
C302315-25mg	25mg	In stock	$187.90
C302315-50mg	50mg	In stock	$305.90
C302315-100mg	100mg	In stock	$494.90

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Basic Description

Synonyms	1265229-25-1\|Debio-1347\|CH5183284\|zoligratinib\|CH5183284 (Debio-1347)\|CH-5183284\|Debio 1347\|FF284\|(5-Amino-1-(2-methyl-1H-benzo[d]imidazol-6-yl)-1H-pyrazol-4-yl)(1H-indol-2-yl)methanone\|NR9ZYH80Z8\|CHEMBL3907479\|Methanone, (5-amino-1-(2-methyl-1H-benzimida
Specifications & Purity	Moligand™, ≥99%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Fibroblast growth factor receptor 1 inhibitor

Names and Identifiers

Pubchem Sid	488202056
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488202056
IUPAC Name	[5-amino-1-(2-methyl-3H-benzimidazol-5-yl)pyrazol-4-yl]-(1H-indol-2-yl)methanone
INCHI	InChI=1S/C20H16N6O/c1-11-23-16-7-6-13(9-17(16)24-11)26-20(21)14(10-22-26)19(27)18-8-12-4-2-3-5-15(12)25-18/h2-10,25H,21H2,1H3,(H,23,24)
InChi Key	BEMNJULZEQTDJY-UHFFFAOYSA-N
Canonical SMILES	CC1=NC2=C(N1)C=C(C=C2)N3C(=C(C=N3)C(=O)C4=CC5=CC=CC=C5N4)N
Isomeric SMILES	CC1=NC2=C(N1)C=C(C=C2)N3C(=C(C=N3)C(=O)C4=CC5=CC=CC=C5N4)N
PubChem CID	66555680
Molecular Weight	356.38

PubChem CID

CAS Registry No.

RCSB PDB Ligand

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Certificates

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10 results found

Lot Number	Certificate Type	Date	Item
D23201051	Certificate of Analysis	Mar 27, 2023	C302315
D23201052	Certificate of Analysis	Mar 27, 2023	C302315
D23201061	Certificate of Analysis	Mar 27, 2023	C302315
D23201062	Certificate of Analysis	Mar 27, 2023	C302315
D23201066	Certificate of Analysis	Mar 27, 2023	C302315
D23201067	Certificate of Analysis	Mar 27, 2023	C302315
D23201069	Certificate of Analysis	Mar 27, 2023	C302315
D23201076	Certificate of Analysis	Mar 27, 2023	C302315
D2320526	Certificate of Analysis	Mar 27, 2023	C302315
D2320533	Certificate of Analysis	Mar 27, 2023	C302315

References

1. Nakanishi Y, Akiyama N, Tsukaguchi T, Fujii T, Sakata K, Sase H, Isobe T, Morikami K, Shindoh H, Mio T et al.. (2014) The fibroblast growth factor receptor genetic status as a potential predictor of the sensitivity to CH5183284/Debio 1347, a novel selective FGFR inhibitor.. Mol Cancer Ther, 13 (11): (2547-58). [PMID:25169980]
2. Voss MH, Hierro C, Heist RS, Cleary JM, Meric-Bernstam F, Tabernero J, Janku F, Gandhi L, Iafrate AJ, Borger DR et al.. (2019) A Phase I, Open-Label, Multicenter, Dose-escalation Study of the Oral Selective FGFR Inhibitor Debio 1347 in Patients with Advanced Solid Tumors Harboring FGFR Gene Alterations.. Clin Cancer Res, 25 (9): (2699-2707). [PMID:30745300]

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Basic Description