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| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Basic Description
| Synonyms | Chalcone | trans-Chalcone | (E)-Chalcone | 614-47-1 | 94-41-7 | Benzalacetophenone | Benzylideneacetophenone | Chalkone | Phenyl styryl ketone | Cinnamophenone | 2-Benzalacetophenone | 1,3-DIPHENYL-2-PROPEN-1-ONE | 1,3-Diphenylpropenone | (2E)-1,3-diphenylprop-2-en-1-one | 2-Benzyli |
|---|---|
| Specifications & Purity | 10mM in DMSO |
| Biochemical and Physiological Mechanisms | 1,3-Diphenyl-2-propenone (chalcone) inhibits the proliferation of human breast cancer cell lines, MCF-7 and MDA-MB-231 by inducing apoptosis and blocking cell cycle progression in the G2/M phase. It is an inhibitor of Plasmodium falciparum cyclin-dependen |
| Storage Temp | Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| Product Description | 1,3-Diphenyl-2-propenone was used in the preparation of pharmacologically-interesting heterocyclic systems like pyrazolines and pyrimidines。 |
Associated Targets(Human)
MAOB Tclin Amine oxidase [flavin-containing] B (1 Activities)
DHFR Tclin Dihydrofolate reductase (3072 Activities)
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ALOX5 Tclin Arachidonate 5-lipoxygenase (6568 Activities)
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AR Tclin Androgen Receptor (11781 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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VDR Tclin Vitamin D receptor (26531 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
MAOA Tclin Monoamine oxidase A (11911 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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MAOB Tclin Monoamine oxidase B (8835 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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PTGS2 Tclin Cyclooxygenase-2 (13999 Activities)
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|---|
XDH Tclin Xanthine dehydrogenase (1038 Activities)
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|---|
TXNRD1 Tclin Thioredoxin reductase 1 (99 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
BCHE Tclin Butyrylcholinesterase (7174 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
AMY2A Tclin Pancreatic alpha-amylase (74 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
TNFRSF1A Tchem Tumor necrosis factor receptor R1 (157 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
KCNMA1 Tclin Calcium-activated potassium channel subunit alpha-1 (435 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Homo sapiens (32628 Activities)
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A498 (42825 Activities)
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ACHN (49357 Activities)
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|---|
BT-20 (503 Activities)
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|---|
Caco-2 (12174 Activities)
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|---|
CAKI-1 (44928 Activities)
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|---|
CCRF-CEM (65223 Activities)
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|---|
COLO 205 (50209 Activities)
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DLD-1 (17511 Activities)
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DU-145 (51482 Activities)
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|---|
HL-60 (67320 Activities)
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|---|
HT-29 (80576 Activities)
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K562 (73714 Activities)
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KM12 (47707 Activities)
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M14 (47487 Activities)
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MCF7 (126967 Activities)
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MOLT-4 (49676 Activities)
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OVCAR-3 (48710 Activities)
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OVCAR-4 (44535 Activities)
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OVCAR-5 (45555 Activities)
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OVCAR-8 (47708 Activities)
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PANC-1 (6144 Activities)
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PC-3 (62116 Activities)
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RPMI-8226 (44974 Activities)
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RXF 393 (41971 Activities)
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SF-295 (48000 Activities)
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SK-MEL-2 (46422 Activities)
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SK-MEL-28 (48833 Activities)
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SK-MEL-5 (47095 Activities)
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SK-OV-3 (52876 Activities)
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SN12C (47755 Activities)
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SNB-19 (46794 Activities)
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TK-10 (45540 Activities)
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U-251 (51189 Activities)
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U2OS (164939 Activities)
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UACC-257 (46019 Activities)
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Associated Targets(non-human)
Cryz Quinone oxidoreductase (288 Activities)
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Pseudomonas aeruginosa (123386 Activities)
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Klebsiella pneumoniae (43867 Activities)
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Staphylococcus aureus (210822 Activities)
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Dickeya chrysanthemi (75 Activities)
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Escherichia coli (133304 Activities)
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Streptococcus mutans (2687 Activities)
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Streptococcus pyogenes (16140 Activities)
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Bacillus pumilus (984 Activities)
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Aspergillus niger (16508 Activities)
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|---|
Bacillus thuringiensis (718 Activities)
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Mycobacterium tuberculosis (203094 Activities)
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Saccharomyces cerevisiae (19171 Activities)
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|---|
Leishmania infantum (5912 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Trypanosoma brucei (78846 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Entamoeba histolytica (2676 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Plasmodium falciparum (966862 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Candida albicans (78123 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Trichoderma viride (1263 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Trichophyton rubrum (3646 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Aureobasidium pullulans (46 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Leishmania amazonensis (3813 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Leishmania braziliensis (1091 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Leishmania donovani (89745 Activities)
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|---|
Trypanosoma cruzi (99888 Activities)
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Caenorhabditis elegans (1055 Activities)
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|---|
Mus musculus (284745 Activities)
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Rattus norvegicus (775804 Activities)
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Talaromyces funiculosus (619 Activities)
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Chaetomium globosum (22 Activities)
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Paecilomyces variotii (130 Activities)
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3T3-L1 (3664 Activities)
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CHO (4503 Activities)
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L1210 (27553 Activities)
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MDCK (10148 Activities)
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P388 (20296 Activities)
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RAW264.7 (28094 Activities)
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NIH3T3 (5395 Activities)
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L929 (3802 Activities)
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Xanthomonas oryzae (286 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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srtA Sortase A (641 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Luciferin 4-monooxygenase (66902 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
PYK Pyruvate kinase (6726 Activities)
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Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Athelia rolfsii (768 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Culex quinquefasciatus (137 Activities)
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Kluyveromyces lactis (70 Activities)
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Ogataea angusta (372 Activities)
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Rhizoctonia solani (2251 Activities)
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Blood (6 Activities)
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Mechanisms of Action
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
Names and Identifiers
| IUPAC Name | (E)-1,3-diphenylprop-2-en-1-one |
|---|---|
| INCHI | InChI=1S/C15H12O/c16-15(14-9-5-2-6-10-14)12-11-13-7-3-1-4-8-13/h1-12H/b12-11+ |
| InChi Key | DQFBYFPFKXHELB-VAWYXSNFSA-N |
| Canonical SMILES | C1=CC=C(C=C1)C=CC(=O)C2=CC=CC=C2 |
| Isomeric SMILES | C1=CC=C(C=C1)/C=C/C(=O)C2=CC=CC=C2 |
| WGK Germany | 3 |
| RTECS | FL6900000 |
| PubChem CID | 637760 |
| Molecular Weight | 208.26 |
| Reaxy-Rn | 742765 |
Certificates
Certificate of Analysis(COA)
Enter Lot Number to search for COA:
Chemical and Physical Properties
| Flash Point(°F) | 235.4 °F |
|---|---|
| Flash Point(°C) | 113 °C |
| Boil Point(°C) | 348 °C |
| Melt Point(°C) | 55-59℃ |
Safety and Hazards(GHS)
| Pictogram(s) | GHS07 |
|---|---|
| Signal | Warning |
| Hazard Statements | H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed |
| Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P337+P317:If eye irritation persists: Get medical help. P319:Get medical help if you feel unwell. |
| WGK Germany | 3 |
| RTECS | FL6900000 |
| Reaxy-Rn | 742765 |
| Merck Index | 2037 |
Related Documents
FAQs and Articles
FAQ
3-Chloroperoxybenzoic acid, m-CPBA
Categories: Technical articles
Citations of This Product
| 1. Chengshuai Li, Lijing Zhang, Decao Niu, Shuzhen Nan, Xiumei Miao, Xiaowei Hu, Hua Fu. (2021) Investigation of flavonoid expression and metabolite content patterns during seed formation of Artemisia sphaerocephala Krasch.. SEED SCIENCE RESEARCH, 31 (2): (136-148). [PMID:] |
| 2. Zhang Haipin, Song Huijia, Tian Xuemeng, Wang Yue, Hao Yi, Wang Wenting, Gao Ruixia, Yang Wan, Ke YuShen, Tang Yuhai. (2021) Magnetic imprinted nanoparticles with synergistic tailoring of covalent and non-covalent interactions for purification and detection of procyanidin B2. MICROCHIMICA ACTA, 188 (1): (1-12). [PMID:33403455] |
| 3. Su-zhen Zhu, Li Zhang, Jing Zhang, Yin-long Guo. (2020) Arc Plasma-Based Dissociation Device: Fingerprinting Mass Spectrometric Analysis Realized at Atmospheric Condition. ANALYTICAL CHEMISTRY, 92 (21): (14633–14639). [PMID:33085455] |
References
| 1. Chengshuai Li, Lijing Zhang, Decao Niu, Shuzhen Nan, Xiumei Miao, Xiaowei Hu, Hua Fu. (2021) Investigation of flavonoid expression and metabolite content patterns during seed formation of Artemisia sphaerocephala Krasch.. SEED SCIENCE RESEARCH, 31 (2): (136-148). [PMID:] |
| 2. Zhang Haipin, Song Huijia, Tian Xuemeng, Wang Yue, Hao Yi, Wang Wenting, Gao Ruixia, Yang Wan, Ke YuShen, Tang Yuhai. (2021) Magnetic imprinted nanoparticles with synergistic tailoring of covalent and non-covalent interactions for purification and detection of procyanidin B2. MICROCHIMICA ACTA, 188 (1): (1-12). [PMID:33403455] |
| 3. Su-zhen Zhu, Li Zhang, Jing Zhang, Yin-long Guo. (2020) Arc Plasma-Based Dissociation Device: Fingerprinting Mass Spectrometric Analysis Realized at Atmospheric Condition. ANALYTICAL CHEMISTRY, 92 (21): (14633–14639). [PMID:33085455] |