Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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C287594-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $47.90 | |
C287594-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $165.90 | |
C287594-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $279.90 | |
C287594-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $559.90 | |
C287594-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $907.90 |
Potent and selective class IIa HDAC inhibitor; brain penetrant
Synonyms | 2-(2-Fluorophenyl)-N-hydroxy-2-(4-(5-(trifluoromethyl)pyrimidin-2-yl)phenyl)acetamide | CHDI-390576 |
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Specifications & Purity | ≥98%(HPLC) |
Biochemical and Physiological Mechanisms | Potent and selective class IIa histone deacetylase (HDAC) inhibitor (IC50values are 31, 50, 54 and 60 nM for HDAC7, HDAC9, HDAC4 and HDAC5, respectively). Displays >100-fold selectivity for class IIa HDACs over other HDACs. Brain penetrant. |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
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IUPAC Name | 2-(2-fluorophenyl)-N-hydroxy-2-[4-[5-(trifluoromethyl)pyrimidin-2-yl]phenyl]acetamide |
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INCHI | InChI=1S/C19H13F4N3O2/c20-15-4-2-1-3-14(15)16(18(27)26-28)11-5-7-12(8-6-11)17-24-9-13(10-25-17)19(21,22)23/h1-10,16,28H,(H,26,27) |
InChi Key | LMGDHGQJJLEAPQ-UHFFFAOYSA-N |
Canonical SMILES | C1=CC=C(C(=C1)C(C2=CC=C(C=C2)C3=NC=C(C=N3)C(F)(F)F)C(=O)NO)F |
Isomeric SMILES | C1=CC=C(C(=C1)C(C2=CC=C(C=C2)C3=NC=C(C=N3)C(F)(F)F)C(=O)NO)F |
PubChem CID | 81689842 |
Molecular Weight | 391.32 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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G2418085 | Certificate of Analysis | Apr 10, 2024 | C287594 |
G2418086 | Certificate of Analysis | Apr 10, 2024 | C287594 |
G2418106 | Certificate of Analysis | Apr 10, 2024 | C287594 |
G2418107 | Certificate of Analysis | Apr 10, 2024 | C287594 |
G2418108 | Certificate of Analysis | Apr 10, 2024 | C287594 |
G2418109 | Certificate of Analysis | Apr 10, 2024 | C287594 |
G2418110 | Certificate of Analysis | Apr 10, 2024 | C287594 |
G2418111 | Certificate of Analysis | Apr 10, 2024 | C287594 |
G2418112 | Certificate of Analysis | Apr 10, 2024 | C287594 |
G2418113 | Certificate of Analysis | Apr 10, 2024 | C287594 |
Solubility | Solvent:DMSO, Max Conc. mg/mL: 39.13, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 39.13, Max Conc. mM: 100 |
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