Chelerythrine chloride - 98%, high purity , CAS No.3895-92-9

Item Number

D133831

• Synonyms: Chelerythrine hydrochloride | Q-200825 | SR-01000075750 | UNII-7IC98TZ0PZ | BCP0726000282 | CHELERYTHRINIUM CHLORIDE | HMS3260B04 | Toddalin chloride | Q-100414 | AKOS016010038 | Chelerythrine HCl | NSC646662 | NSC-646662 | CCG-206741 | Myristic alcohol |
• Specifications & Purity: Moligand™, ≥98%
• Biochemical and Physiological Mechanisms: Cell-permeable inhibitor of protein kinase C (IC50= 660 nM); competitive with respect to the phosphate acceptor and non-competitive with respect to ATP. Has a wide range of biological activities, including antiplatelet, anti-inflammatory, antibacterial an
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™

Product Description

Chelerythrine chloride Is an isoquinoline alkaloid isolated from the root of Zanthoxylum simulans, Chelidonium majus L., and other Papaveraceae. It has been reported to be a potent and selective inhibitor of PKC (protein kinase C, IC50=0.66 μM), and an independent activator of MAPK pathways. The compound has been observed to induce apoptosis in HL-60 human promyelocytic leukemia cells. The proposed method of action of apoptotic stimulation is through the inhibition of binding BclXL to Bax or Bad at an IC50 = 1.5 μM. When used in combination with cisplatin inhibition of cell proliferation of non-small cell lung cancer cells was increased in an additive/synergistic pattern. Also through inhibition of thromboxane formation and phosphoinositide breakdown chelerythrine chloride was demonstrated to inhibit rabbit platelet aggregation and release. Chelerythrine Chloride is an inhibitor of Cox-2.
A potent and selective inhibitor of protein kinase C.