Determine the necessary mass, volume, or concentration for preparing a solution.
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SKU | Size | Availability | Price | Qty |
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C104903-20mg | 20mg | In stock | $69.90 |
Synonyms | (R)-4-((3R,5S,7R,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid | Acidum chenodeoxycholicum [INN-Latin] | Anthropodeoxycholic acid | (+)-chenodeoxycholate | Chenodesoxycholsaeure [German] |
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Specifications & Purity | Moligand™, analytical standard |
Biochemical and Physiological Mechanisms | Chenodeoxycholic Acid (CDCA), is a hydrophobic primary bile acid that activates nuclear receptors involved in cholesterol metabolism. Bile acids are essential for solubilization and transport of dietary lipids, are the major products of c |
Storage Temp | Protected from light |
Shipped In | Normal |
Grade | analytical standard, Moligand™ |
Action Type | AGONIST, ANTAGONIST |
Mechanism of action | Agonist of Farnesoid X receptor;Antagonist of FPR1;Agonist of GPBA receptor |
ALogP | 4.9 |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | (4R)-4-[(3R,5S,7R,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid |
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INCHI | InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 |
InChi Key | RUDATBOHQWOJDD-BSWAIDMHSA-N |
Canonical SMILES | CC(CCC(=O)O)C1CCC2C1(CCC3C2C(CC4C3(CCC(C4)O)C)O)C |
Isomeric SMILES | C[C@H](CCC(=O)O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2[C@@H](C[C@H]4[C@@]3(CC[C@H](C4)O)C)O)C |
PubChem CID | 10133 |
Molecular Weight | 392.58 |
PubChem CID | 10133 |
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DrugBank Ligand | DB06777 |
Wikipedia | Chenodeoxycholic_acid |
CAS Registry No. | 474-25-9 |
ChEMBL Ligand | CHEMBL240597 |
ChEBI | CHEBI:16755 |
NURSA Ligand | 10.1621/H7NZZJBHW4 |
RCSB PDB Ligand | JN3 |
DrugCentral Ligand | 4361 |
GPCRdb Ligand | chenodeoxycholic acid |
Enter Lot Number to search for COA:
Sensitivity | Light sensitive. |
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Pictogram(s) | GHS08, GHS07 |
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Signal | Warning |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed H312:Harmful in contact with skin H332:Harmful if inhaled H361:Suspected of damaging fertility or the unborn child |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P317:Get emergency medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
Merck Index | 2054 |
1. Mu-Qiang Wang, Zhi-Neng You, Bing-Yi Yang, Zi-Wei Xia, Qi Chen, Jiang Pan, Chun-Xiu Li, Jian-He Xu. (2023) Machine-Learning-Guided Engineering of an NADH-Dependent 7β-Hydroxysteroid Dehydrogenase for Economic Synthesis of Ursodeoxycholic Acid. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 71 (49): (19672–19681). [PMID:38016669] [10.1021/acs.jafc.3c06339] |
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4. Hua Zheng, Yi-Chuang Xu, Tao Zhao, Zhi Luo, Dian-Guang Zhang, Chang-Chun Song, An-Gen Yu, Xiaoying Tan. (2023) Dietary chenodeoxycholic acid attenuates high-fat diet-induced growth retardation, lipid accumulation and bile acid metabolism disorder in the liver of yellow catfish Pelteobagrus fulvidraco. BRITISH JOURNAL OF NUTRITION, (6): (1-14). [PMID:37905695] [10.1017/S0007114523002489] |
5. Zhiyuan Meng, Sen Yan, Wei Sun, Jin Yan, Miaomiao Teng, Ming Jia, Sinuo Tian, Zhiqiang Zhou, Wentao Zhu. (2023) Chlorothalonil induces obesity in mice by regulating host gut microbiota and bile acids metabolism via FXR pathways. JOURNAL OF HAZARDOUS MATERIALS, 452 (131310). [PMID:37003002] [10.1016/j.jhazmat.2023.131310] |
6. Shuai Liu, Keming Zheng, Yilin Jiang, Susu Gai, Bohan Li, Dehai Li, Shuang Yang, Zhihua Lv. (2023) Biotransformation of Penindolone, an Influenza A Virus Inhibitor. MOLECULES, 28 (3): (1479). [PMID:36771146] [10.3390/molecules28031479] |
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