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CHIR-99021 (CT99021) HCl - ≥98%, high purity , CAS No.252917-06-9

Moligand™
≥98%

CAS#: 252917-06-9
Formula: C₂₂H₁₈Cl₂N₈
Molecular Weight: 465.34
MDL number: MFCD11846251
PubChem CID: 9956119

Item Number

C129710

Grouped product items
SKU	Size	Availability	Price
C129710-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$70.90
C129710-25mg	25mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$319.90
C129710-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$509.90

Potent, highly selective GSK3 inhibitor

Basic Description

Synonyms	252917-06-9\|CHIR-99021\|CHIR99021\|laduviglusib\|CHIR 99021\|CT99021\|CT-99021\|6-((2-((4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)amino)nicotinonitrile\|GSK-3 Inhibitor XVI\|CHIR-911\|6-[2-[4-(2,4-Dichlorophenyl)-5-(4-methyl-1H
Specifications & Purity	≥98%
Storage Temp	Store at -20°C
Shipped In	Dry ice
Grade	Moligand™
Product Description	CHIR-99021 (CT99021) HCl is hydrochloride of CHIR-99021, which is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM; ability to distinguish between GSK-3 and its closest homologs Cdc2 and ERK2.

Associated Targets

CDK1 Tchem Cyclin-dependent kinase 1 1 Activities

Discover Target: CDK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GSK3B Tclin Glycogen synthase kinase-3 beta 6 Activities

Discover Target: GSK3B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GSK3A Tclin Glycogen synthase kinase-3 alpha 4 Activities

Discover Target: GSK3A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAPK1 Tchem Mitogen-activated protein kinase 1 1 Activities

Discover Target: MAPK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	6-[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)pyrimidin-2-yl]amino]ethylamino]pyridine-3-carbonitrile
INCHI	InChI=1S/C22H18Cl2N8/c1-13-10-29-21(31-13)17-12-30-22(32-20(17)16-4-3-15(23)8-18(16)24)27-7-6-26-19-5-2-14(9-25)11-28-19/h2-5,8,10-12H,6-7H2,1H3,(H,26,28)(H,29,31)(H,27,30,32)
InChi Key	AQGNHMOJWBZFQQ-UHFFFAOYSA-N
Canonical SMILES	CC1=CN=C(N1)C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)Cl)NCCNC4=NC=C(C=C4)C#N
Isomeric SMILES	CC1=CN=C(N1)C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)Cl)NCCNC4=NC=C(C=C4)C#N
PubChem CID	9956119
Molecular Weight	465.34
Reaxy-Rn	25763160

Certificates

Certificate of Analysis(COA)

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2 results found

Lot Number	Certificate Type	Date	Item
B1525018	Certificate of Analysis	Jun 05, 2024	C129710
K2313016	Certificate of Analysis	Sep 13, 2022	C129710

Safety and Hazards(GHS)

Pictogram(s)	GHS06, GHS07
Signal	Danger
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H300:Fatal if swallowed
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
Reaxy-Rn	25763160

References

1. Saxena M et al.. (2020) A Pygopus 2-Histone Interaction Is Critical for Cancer Cell Dedifferentiation and Progression in Malignant Breast Cancer.. Cancer Res, 80 (17): (3631-3648). [PMID:32586983]
2. Fagnocchi L et al.. (2016) A Myc-driven self-reinforcing regulatory network maintains mouse embryonic stem cell identity.. Nat Commun, 7 (11903). [PMID:27301576]
3. Balmus G et al.. (2019) ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks.. Nat Commun, 10 (87). [PMID:30622252]
4. Elling U et al.. (2019) Derivation and maintenance of mouse haploid embryonic stem cells.. Nat Protoc, 14 (7): (1991-2014). [PMID:31160788]
5. Jeziorowska D et al.. (2017) Differential Sarcomere and Electrophysiological Maturation of Human iPSC-Derived Cardiac Myocytes in Monolayer vs. Aggregation-Based Differentiation Protocols.. Int J Mol Sci, 18 (6): [PMID:28587156]
6. Song J & Millman JR. (2016) Economic 3D-printing approach for transplantation of human stem cell-derived ß-like cells.. Biofabrication, 9 (015002). [PMID:27906687]
7. Dole NS et al.. (2021) Mechanosensitive miR-100 coordinates TGFβ and Wnt signaling in osteocytes during fluid shear stress.. FASEB J, 35 (10): (e21883). [PMID:34569659]
8. Sato H et al.. (2016) Microfabric Vessels for Embryoid Body Formation and Rapid Differentiation of Pluripotent Stem Cells.. Sci Rep, 6 (31063). [PMID:27507707]
9. Hall AE et al.. (2022) RNA splicing is a key mediator of tumour cell plasticity and a therapeutic vulnerability in colorectal cancer.. Nat Commun, 13 (2791). [PMID:35589755]

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