Basic Description

Synonyms	Chloramine-T trihydrate\|7080-50-4\|Tosylchloramide sodium trihydrate\|Chloramine T trihydrate\|Chloraseptin\|Hydroclonazone\|Chlorazol\|Minachlor\|Trichlorol\|Disifin\|Clorina\|Euclorina\|Halamid\|UNII-4IU6VSV0EI\|Chloramine-t trihydrate [MI]\|DTXSID6040795\|MFCD0014906
Specifications & Purity	ACS, ≥98%
Storage Temp	Protected from light,Argon charged
Shipped In	Normal
Grade	ACS
Product Description	Chloramine T (CAT) trihydrate is a commonly used reagent for organic synthesis especially in heterocyclic chemistry. CAT is an active chlorine compound that shows antimicrobial activity. for the detection of halogens and bromate；Chloramine T trihydrate may be used as an oxidizing agent in the synthesis of 8-chloro-[1,2,4]triazolo[4,3-a]pyrazine derivatives and novel isoxazolines. It may also be used in the synthesis of the following compounds: · Nitrile imines by the oxidative dehydrogenation of N-(nitrobenzyl)-imidazole aldehyde hydrazine. · Mono-N-tosylated-1,2-diamines. · 3,5-Disubstituted isoxazoles. · Fused 3,6-disubstituted triazolothiadiazoles by the oxidative cyclization of N-heteroaryl-substituted hydrazones. Nitrene source for aziridinations and aminohydroxylations.

Associated Targets

EHMT2 Tchem Histone-lysine N-methyltransferase EHMT2 0 Activities

Discover Target: EHMT2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 0 Activities

Discover Target: USP1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KAT2A Tchem Histone acetyltransferase KAT2A 0 Activities

Discover Target: KAT2A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

Pubchem Sid	488189976
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488189976
IUPAC Name	sodium;chloro-(4-methylphenyl)sulfonylazanide;trihydrate
INCHI	InChI=1S/C7H7ClNO2S.Na.3H2O/c1-6-2-4-7(5-3-6)12(10,11)9-8;;;;/h2-5H,1H3;;3*1H2/q-1;+1;;;
InChi Key	NZYOAGBNMCVQIV-UHFFFAOYSA-N
Canonical SMILES	CC1=CC=C(C=C1)S(=O)(=O)[N-]Cl.O.O.O.[Na+]
Isomeric SMILES	CC1=CC=C(C=C1)S(=O)(=O)[N-]Cl.O.O.O.[Na+]
WGK Germany	2
PubChem CID	517414
UN Number	3263
Molecular Weight	281.69
Beilstein	3924168

Certificates

Certificate of Analysis(COA)

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5 results found

Lot Number	Certificate Type	Date	Item
B2306797	Certificate of Analysis	Sep 27, 2022	C104060
I2213176	Certificate of Analysis	Sep 27, 2022	C104060
I2213179	Certificate of Analysis	Sep 27, 2022	C104060
I2205461	Certificate of Analysis	Sep 09, 2022	C104060
J2211802	Certificate of Analysis	Sep 09, 2022	C104060

Chemical and Physical Properties

Solubility	Soluble in water and ethyl alcohol. Insoluble in benzene and ethers.
Sensitivity	Light sensitive.Air & Moisture Sensitive
Flash Point(°F)	377.6 °F
Flash Point(°C)	192 °C
Melt Point(°C)	167-170°C

Safety and Hazards(GHS)

Pictogram(s)	GHS08, GHS05, GHS07
Signal	Danger
Hazard Statements	H314:Causes severe skin burns and eye damage H302:Harmful if swallowed H334:May cause allergy or asthma symptoms or breathing difficulties if inhaled
Precautionary Statements	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P310:Immediately call a POISON CENTER or doctor/physician. P342+P311:IF experiencing respiratory symptoms: Call a POISON CENTER/doctor/... P303+P361+P353:IF ON SKIN (or hair): Take off Immediately all contaminated clothing. Rinse SKIN with water [or shower]. P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P363:Wash contaminated clothing before reuse. P330:Rinse mouth. P301+P312:IF SWALLOWED: call a POISON CENTER/doctor/... IF you feel unwell.
WGK Germany	2
Merck Index	2075

References

1. G Li,K B Sharpless. (1996-08-01) Catalytic asymmetric aminohydroxylation provides a short taxol side-chain synthesis.. Acta chemica Scandinavica (Copenhagen, Denmark : 1989), 50 ((8)): (649-651). [PMID:8756354]
2. Satoshi Minakata,Daisuke Kano,Yoji Oderaotoshi,Mitsuo Komatsu. (2003-12-25) Silica-water reaction media: its application to the formation and ring opening of aziridines.. Angewandte Chemie (International ed. in English), 43 ((1)): (79-81). [PMID:14694476]
3. G D Kishore Kumar,Sundarababu Baskaran. (2004-04-08) Heteropoly acid as a novel nitrene transfer agent: a facile and practical aziridination of olefins with Chloramine-T.. Chemical communications (Cambridge, England), (1026-1027). [PMID:15069527]
4. Maria Koufaki,Theano Fotopoulou,Marianna Kapetanou,Georgios A Heropoulos,Efstathios S Gonos,Niki Chondrogianni. (2014-07-06) Microwave-assisted synthesis of 3,5-disubstituted isoxazoles and evaluation of their anti-ageing activity.. European journal of medicinal chemistry, 83 (508-515). [PMID:24996137]
5. Heemin Kang,Yuze Zeng,Shyni Varghese. (2018-07-23) Functionally graded multilayer scaffolds for in vivo osteochondral tissue engineering.. Acta biomaterialia, 78 (365-377). [PMID:30031911]
6. M Nagl,V A Nguyen,W Gottardi,H Ulmer,R Höpfl. (2003-09-27) Tolerability and efficacy of N-chlorotaurine in comparison with chloramine T for the treatment of chronic leg ulcers with a purulent coating: a randomized phase II study.. The British journal of dermatology, 149 ((3)): (590-597). [PMID:14510994]
7. Kun Han,Yanting Zhang,Zhenwei Yang. (2019-03-15) Cilostazol protects rats against alcohol-induced hepatic fibrosis via suppression of TGF-β1/CTGF activation and the cAMP/Epac1 pathway.. Experimental and therapeutic medicine, 17 ((3)): (2381-2388). [PMID:30867723]

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Chloramine T trihydrate - ACS,98%, high purity , CAS No.7080-50-4