Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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C193834-250mg | 250mg | In stock | $53.90 | |
C193834-1g | 1g | In stock | $133.90 | |
C193834-5g | 5g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $465.90 | |
C193834-25g | 25g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $1,527.90 |
Synonyms | chloroquine | Chloraquine | Quinachlor | Bemaco | Bemasulph | Reumachlor | Cidanchin | Arthrochin | Chlorochin | Capquin | Gontochin | Malaquin | Chlorquin | Chloroquina | Dichinalex | Artrichin | Aralen | Chemochin | N4-(7-chloroquinolin-4-yl)-N1,N1-diet |
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Specifications & Purity | Moligand™, ≥97% |
Storage Temp | Store at 2-8°C,Argon charged |
Shipped In | Wet ice |
Grade | Moligand™ |
Action Type | AGONIST |
Mechanism of action | Agonist of MRGPRX1;Agonist of TAS2R3 |
Note | 50mg卖完停产,不再备货 |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 4-N-(7-chloroquinolin-4-yl)-1-N,1-N-diethylpentane-1,4-diamine |
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INCHI | InChI=1S/C18H26ClN3/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21) |
InChi Key | WHTVZRBIWZFKQO-UHFFFAOYSA-N |
Canonical SMILES | CCN(CC)CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl |
Isomeric SMILES | CCN(CC)CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl |
Alternate CAS | 54-05-7 |
PubChem CID | 2719 |
NSC Number | 187208 |
MeSH Entry Terms | Aralen;Arechine;Arequin;Chingamin;Chlorochin;Chloroquine;Chloroquine Sulfate;Chloroquine Sulphate;Khingamin;Nivaquine;Sulfate, Chloroquine;Sulphate, Chloroquine |
Molecular Weight | 319.87 |
Wikipedia | Chloroquine |
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CAS Registry No. | 54-05-7 |
ChEBI | CHEBI:3638 |
DrugBank Ligand | DB00608 |
PubChem CID | 2719 |
ChEMBL Ligand | CHEMBL76 |
BitterDB Ligand | 87 |
Immunopaedia Search | chloroquine |
RCSB PDB Ligand | CLQ |
Reactome Reaction | R-HSA-9683467, R-HSA-9683478, R-HSA-5625574, R-HSA-597628 |
Reactome Drug | R-ALL-9683477, R-ALL-9678941, R-ALL-9690591 |
DrugCentral Ligand | 607 |
GPCRdb Ligand | chloroquine |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
F2425259 | Certificate of Analysis | Jun 13, 2024 | C193834 |
F2425258 | Certificate of Analysis | Jun 13, 2024 | C193834 |
F2425257 | Certificate of Analysis | Jun 13, 2024 | C193834 |
F2425256 | Certificate of Analysis | Jun 13, 2024 | C193834 |
F2425255 | Certificate of Analysis | Jun 13, 2024 | C193834 |
H2103193 | Certificate of Analysis | May 13, 2024 | C193834 |
H2103190 | Certificate of Analysis | May 09, 2024 | C193834 |
L2023149 | Certificate of Analysis | Oct 25, 2023 | C193834 |
F2214116 | Certificate of Analysis | May 30, 2022 | C193834 |
F2214115 | Certificate of Analysis | May 30, 2022 | C193834 |
F2214114 | Certificate of Analysis | May 30, 2022 | C193834 |
C2426026 | Certificate of Analysis | May 30, 2022 | C193834 |
H2325058 | Certificate of Analysis | May 30, 2022 | C193834 |
C2226510 | Certificate of Analysis | Mar 03, 2022 | C193834 |
C2226253 | Certificate of Analysis | Mar 03, 2022 | C193834 |
K2330168 | Certificate of Analysis | Mar 03, 2022 | C193834 |
C2226249 | Certificate of Analysis | Mar 03, 2022 | C193834 |
Solubility | Chloroform (Slightly), Methanol (Slightly) |
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Sensitivity | Air sensitive;Heat sensitive |
Specific Rotation[α] | -1.0 to +1.0 deg (C=1, methanol) |
Melt Point(°C) | 91 °C |
Pictogram(s) | GHS07 |
---|---|
Signal | Warning |
Hazard Statements | H302:Harmful if swallowed |
Precautionary Statements | P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help. |
Starting at $47.90
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28. Yi Wang, Yang Yao, Rong Li, Binghui Wu, Huiqin Lu, Jing Cheng, Zhe Liu, Junhui Du. (2021) Different effects of anti-VEGF drugs (Ranibizumab, Aflibercept, Conbercept) on autophagy and its effect on neovascularization in RF/6A cells. MICROVASCULAR RESEARCH, 138 (104207). [PMID:34119535] [10.1016/j.mvr.2021.104207] |
29. Yu Zhang, Yan Liu, Yinxing Zhou, Ziming Zheng, Wenqi Tang, Mengzi Song, Jinglin Wang, Kaiping Wang. (2021) Lentinan inhibited colon cancer growth by inducing endoplasmic reticulum stress-mediated autophagic cell death and apoptosis. CARBOHYDRATE POLYMERS, 267 (118154). [PMID:34119128] [10.1016/j.carbpol.2021.118154] |
30. Dai Tianming, Wang Min, Wang Pengzhen, Dai Libing, Dai Renke, Meng Qingqi. (2021) Inhibition effects of eight anti-coronavirus drugs on glycosides metabolism and glycosidases in human gut microflora. PHARMAZIE, 76 (5): (195-201). [PMID:33964992] [10.1691/ph.2021.01005] |
31. Dawei Yang, Xiaoyu Tian, Yuchen Ye, Yin Liang, Jie Zhao, Tao Wu, Na Lu. (2021) Identification of GL-V9 as a novel senolytic agent against senescent breast cancer cells. LIFE SCIENCES, 272 (119196). [PMID:33617857] [10.1016/j.lfs.2021.119196] |
32. Peiwen Zhang, Shen Chen, Huanwen Tang, Wanjun Fang, Ke Chen, Xu Chen. (2021) CoQ10 protects against acetaminophen-induced liver injury by enhancing mitophagy. TOXICOLOGY AND APPLIED PHARMACOLOGY, 410 (115355). [PMID:33271250] [10.1016/j.taap.2020.115355] |
33. Xu Shaomei, He Xu, Huang Yibing, Liu Xin, Zhao Lihe, Wang Xinghua, Sun Ying, Ma Pinyi, Song Daqian. (2020) Lysosome-targeted ratiometric fluorescent sensor for monitoring pH in living cells based on one-pot-synthesized carbon dots. MICROCHIMICA ACTA, 187 (8): (1-9). [PMID:32740872] [10.1007/s00604-020-04462-w] |
34. Yilin Zhang, Dongwei Liu, Zhangsuo Liu. (2020) The benzo[b]fluoranthene in the atmospheric fine particulate matter induces mouse glomerular podocytes injury via inhibition of autophagy. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 195 (110403). [PMID:32193019] [10.1016/j.ecoenv.2020.110403] |
35. Shengrui Zhang, Xiaohui Ji, Jin Liu, Qin Wang, Lingxia Jin. (2020) One-step synthesis of yellow-emissive carbon dots with a large Stokes shift and their application in fluorimetric imaging of intracellular pH. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 227 (117677). [PMID:31675656] [10.1016/j.saa.2019.117677] |
36. Peng Cao, Yu Zhang, Zi Huang, Mitchell A. Sullivan, Zihao He, Jinglin Wang, Zehong Chen, Huiping Hu, Kaiping Wang. (2019) The Preventative Effects of Procyanidin on Binge Ethanol-Induced Lipid Accumulation and ROS Overproduction via the Promotion of Hepatic Autophagy. MOLECULAR NUTRITION & FOOD RESEARCH, 63 (18): (1801255). [PMID:31336037] [10.1002/mnfr.201801255] |
37. Lingmin Zhang, Qingqing Xia, Yingying Zhou, Jie Li. (2019) Endoplasmic reticulum stress and autophagy contribute to cadmium-induced cytotoxicity in retinal pigment epithelial cells. TOXICOLOGY LETTERS, 311 (105). [PMID:31054874] [10.1016/j.toxlet.2019.05.001] |
38. Xiaoxiao Liang, Zhiqiang Hou, Yuanlong Xie, Feifei Yan, Sisi Li, Xiaobin Zhu, Lin Cai. (2019) Icariin promotes osteogenic differentiation of bone marrow stromal cells and prevents bone loss in OVX mice via activating autophagy. JOURNAL OF CELLULAR BIOCHEMISTRY, 120 (8): (13121-13132). [PMID:30887562] [10.1002/jcb.28585] |
39. Shuang E, Quan-Xing Mao, Xiao-Li Yuan, Xiao-Lei Kong, Xu-Wei Chen, Jian-Hua Wang. (2018) Targeted imaging of the lysosome and endoplasmic reticulum and their pH monitoring with surface regulated carbon dots. Nanoscale, 10 (26): (12788-12796). [PMID:29947397] [10.1039/C8NR03453B] |
40. Shaohong Fang,Xin Wan,Xiaoyi Zou,Song Sun,Xinran Hao,Chenchen Liang,Zhenming Zhang,Fangni Zhang,Bo Sun,Hulun Li,Bo Yu. (2021-01-20) Arsenic trioxide induces macrophage autophagy and atheroprotection by regulating ROS-dependent TFEB nuclear translocation and AKT/mTOR pathway.. Cell death & disease, 12 ((1)): (88-88). [PMID:33462182] |
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31. Dawei Yang, Xiaoyu Tian, Yuchen Ye, Yin Liang, Jie Zhao, Tao Wu, Na Lu. (2021) Identification of GL-V9 as a novel senolytic agent against senescent breast cancer cells. LIFE SCIENCES, 272 (119196). [PMID:33617857] [10.1016/j.lfs.2021.119196] |
32. Peiwen Zhang, Shen Chen, Huanwen Tang, Wanjun Fang, Ke Chen, Xu Chen. (2021) CoQ10 protects against acetaminophen-induced liver injury by enhancing mitophagy. TOXICOLOGY AND APPLIED PHARMACOLOGY, 410 (115355). [PMID:33271250] [10.1016/j.taap.2020.115355] |
33. Xu Shaomei, He Xu, Huang Yibing, Liu Xin, Zhao Lihe, Wang Xinghua, Sun Ying, Ma Pinyi, Song Daqian. (2020) Lysosome-targeted ratiometric fluorescent sensor for monitoring pH in living cells based on one-pot-synthesized carbon dots. MICROCHIMICA ACTA, 187 (8): (1-9). [PMID:32740872] [10.1007/s00604-020-04462-w] |
34. Yilin Zhang, Dongwei Liu, Zhangsuo Liu. (2020) The benzo[b]fluoranthene in the atmospheric fine particulate matter induces mouse glomerular podocytes injury via inhibition of autophagy. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 195 (110403). [PMID:32193019] [10.1016/j.ecoenv.2020.110403] |
35. Shengrui Zhang, Xiaohui Ji, Jin Liu, Qin Wang, Lingxia Jin. (2020) One-step synthesis of yellow-emissive carbon dots with a large Stokes shift and their application in fluorimetric imaging of intracellular pH. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 227 (117677). [PMID:31675656] [10.1016/j.saa.2019.117677] |
36. Peng Cao, Yu Zhang, Zi Huang, Mitchell A. Sullivan, Zihao He, Jinglin Wang, Zehong Chen, Huiping Hu, Kaiping Wang. (2019) The Preventative Effects of Procyanidin on Binge Ethanol-Induced Lipid Accumulation and ROS Overproduction via the Promotion of Hepatic Autophagy. MOLECULAR NUTRITION & FOOD RESEARCH, 63 (18): (1801255). [PMID:31336037] [10.1002/mnfr.201801255] |
37. Lingmin Zhang, Qingqing Xia, Yingying Zhou, Jie Li. (2019) Endoplasmic reticulum stress and autophagy contribute to cadmium-induced cytotoxicity in retinal pigment epithelial cells. TOXICOLOGY LETTERS, 311 (105). [PMID:31054874] [10.1016/j.toxlet.2019.05.001] |
38. Xiaoxiao Liang, Zhiqiang Hou, Yuanlong Xie, Feifei Yan, Sisi Li, Xiaobin Zhu, Lin Cai. (2019) Icariin promotes osteogenic differentiation of bone marrow stromal cells and prevents bone loss in OVX mice via activating autophagy. JOURNAL OF CELLULAR BIOCHEMISTRY, 120 (8): (13121-13132). [PMID:30887562] [10.1002/jcb.28585] |
39. Shuang E, Quan-Xing Mao, Xiao-Li Yuan, Xiao-Lei Kong, Xu-Wei Chen, Jian-Hua Wang. (2018) Targeted imaging of the lysosome and endoplasmic reticulum and their pH monitoring with surface regulated carbon dots. Nanoscale, 10 (26): (12788-12796). [PMID:29947397] [10.1039/C8NR03453B] |
40. Shaohong Fang,Xin Wan,Xiaoyi Zou,Song Sun,Xinran Hao,Chenchen Liang,Zhenming Zhang,Fangni Zhang,Bo Sun,Hulun Li,Bo Yu. (2021-01-20) Arsenic trioxide induces macrophage autophagy and atheroprotection by regulating ROS-dependent TFEB nuclear translocation and AKT/mTOR pathway.. Cell death & disease, 12 ((1)): (88-88). [PMID:33462182] |