Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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C193834-250mg | 250mg | In stock | $53.90 | |
C193834-1g | 1g | In stock | $133.90 | |
C193834-5g | 5g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $465.90 | |
C193834-25g | 25g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $1,527.90 |
Synonyms | chloroquine | Chloraquine | Quinachlor | Bemaco | Bemasulph | Reumachlor | Cidanchin | Arthrochin | Chlorochin | Capquin | Gontochin | Malaquin | Chlorquin | Chloroquina | Dichinalex | Artrichin | Aralen | Chemochin | N4-(7-chloroquinolin-4-yl)-N1,N1-diet |
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Specifications & Purity | Moligand™, ≥97% |
Storage Temp | Store at 2-8°C,Argon charged |
Shipped In | Wet ice |
Grade | Moligand™ |
Action Type | AGONIST |
Mechanism of action | Agonist of MRGPRX1;Agonist of TAS2R3 |
Note | 50mg卖完停产,不再备货 |
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IUPAC Name | 4-N-(7-chloroquinolin-4-yl)-1-N,1-N-diethylpentane-1,4-diamine |
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INCHI | InChI=1S/C18H26ClN3/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21) |
InChi Key | WHTVZRBIWZFKQO-UHFFFAOYSA-N |
Canonical SMILES | CCN(CC)CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl |
Isomeric SMILES | CCN(CC)CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl |
Alternate CAS | 54-05-7 |
PubChem CID | 2719 |
NSC Number | 187208 |
MeSH Entry Terms | Aralen;Arechine;Arequin;Chingamin;Chlorochin;Chloroquine;Chloroquine Sulfate;Chloroquine Sulphate;Khingamin;Nivaquine;Sulfate, Chloroquine;Sulphate, Chloroquine |
Molecular Weight | 319.87 |
Wikipedia | Chloroquine |
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CAS Registry No. | 54-05-7 |
ChEBI | CHEBI:3638 |
DrugBank Ligand | DB00608 |
PubChem CID | 2719 |
ChEMBL Ligand | CHEMBL76 |
BitterDB Ligand | 87 |
Immunopaedia Search | chloroquine |
RCSB PDB Ligand | CLQ |
Reactome Reaction | R-HSA-9683467, R-HSA-9683478, R-HSA-5625574, R-HSA-597628 |
Reactome Drug | R-ALL-9683477, R-ALL-9678941, R-ALL-9690591 |
DrugCentral Ligand | 607 |
GPCRdb Ligand | chloroquine |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
F2425259 | Certificate of Analysis | Jun 13, 2024 | C193834 |
F2425258 | Certificate of Analysis | Jun 13, 2024 | C193834 |
F2425257 | Certificate of Analysis | Jun 13, 2024 | C193834 |
F2425256 | Certificate of Analysis | Jun 13, 2024 | C193834 |
F2425255 | Certificate of Analysis | Jun 13, 2024 | C193834 |
H2103193 | Certificate of Analysis | May 13, 2024 | C193834 |
H2103190 | Certificate of Analysis | May 09, 2024 | C193834 |
L2023149 | Certificate of Analysis | Oct 25, 2023 | C193834 |
F2214116 | Certificate of Analysis | May 30, 2022 | C193834 |
F2214115 | Certificate of Analysis | May 30, 2022 | C193834 |
F2214114 | Certificate of Analysis | May 30, 2022 | C193834 |
C2426026 | Certificate of Analysis | May 30, 2022 | C193834 |
H2325058 | Certificate of Analysis | May 30, 2022 | C193834 |
C2226510 | Certificate of Analysis | Mar 03, 2022 | C193834 |
C2226253 | Certificate of Analysis | Mar 03, 2022 | C193834 |
K2330168 | Certificate of Analysis | Mar 03, 2022 | C193834 |
C2226249 | Certificate of Analysis | Mar 03, 2022 | C193834 |
Solubility | Chloroform (Slightly), Methanol (Slightly) |
---|---|
Sensitivity | Air sensitive;Heat sensitive |
Specific Rotation[α] | -1.0 to +1.0 deg (C=1, methanol) |
Melt Point(°C) | 91 °C |
Pictogram(s) | GHS07 |
---|---|
Signal | Warning |
Hazard Statements | H302:Harmful if swallowed |
Precautionary Statements | P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help. |
Starting at $47.90
1. Xijuan Chao, Dezhi Yao, Chuxuan Chen, Zhiguo Sheng, Benzhan Zhu. (2024) Tetrabromobisphenol A induces neuronal cytotoxicity by inhibiting PINK1-Parkin-mediated mitophagy via upregulating ATF3 expression. SCIENCE OF THE TOTAL ENVIRONMENT, 912 (169175). [PMID:38065503] |
2. Xiaolin Zhang, Zhen Dong, Yuanmiao Yang, Chaolong Liu, Jisheng Li, Wenli Sun, Yikang Zhu, Yang Shen, Zhi Wang, Muhan Lü, Hongjuan Cui. (2023) Morusinol Extracted from Morus alba Inhibits Cell Proliferation and Induces Autophagy via FOXO3a Nuclear Accumulation-Mediated Cholesterol Biosynthesis Obstruction in Colorectal Cancer. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, (19): [PMID:37870273] |
3. Dan Yuan, Qi Li, Qibo Zhang, Feibai Zhou, Qiangzhong Zhao, Mouming Zhao. (2024) Enhanced curcumin transportation across epithelial barrier by mucus-permeable soy protein nanoparticles-mediated dual transcytosis pathways. FOOD CHEMISTRY, 437 (137771). [PMID:37897825] |
4. Yiqian Zhang, Qianrui Huang, Qisi Xu, Chengsen Jia, Yong Xia. (2023) Pimavanserin tartrate induces apoptosis and cytoprotective autophagy and synergizes with chemotherapy on triple negative breast cancer. BIOMEDICINE & PHARMACOTHERAPY, 168 (8): (115665). [PMID:37832400] |
5. Liu Jin, Chen Yuqian, Chen Huan, Wang Yan, Li Danyang, Zhang Qianqian, Chai Limin, Qiu Yuanjie, Zhang Jia, Shen Nirui, Wang Qingting, Wang Jian, Li Manxiang. (2023) Macrophage migration inhibitory factor exacerbates asthmatic airway remodeling via dynamin-related protein 1-mediated autophagy activation. RESPIRATORY RESEARCH, 24 (1): (1-14). [PMID:37674165] |
6. Daxiu Li, Feng Qiu, Ruo Yuan, Yun Xiang. (2023) Multiplexed and amplified electrochemical aptasensor for sensitive assay of piperaquine and mefloquine. SENSORS AND ACTUATORS B-CHEMICAL, 395 (134483). [PMID:32499645] |
7. Peixin Wang, Chenqiong Zhao, Hanjing Zhou, Xiaona Huang, Hanqi Ying, Songying Zhang, Yibin Pan, Haiyan Zhu. (2023) Dysregulation of Histone Deacetylases Inhibits Trophoblast Growth during Early Placental Development Partially through TFEB-Dependent Autophagy-Lysosomal Pathway. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24 (15): (11899). [PMID:37569278] |
8. Zhe Chen, Jia-Yu Zhang, Qian Jiang, Yang-Yang Bao, Zhi-Mei Li, Shui-Hong Zhou, Jiang-Tao Zhong, Zi-Ming Fu, Zai-Zai Cao, Jun Fan, Hong-Tian Yao. (2023) Pepsin Increases the Proliferation of Vocal Cord Leukoplakia Epithelial Cells by Inducing Autophagy. OTOLARYNGOLOGY-HEAD AND NECK SURGERY, [PMID:37264983] |
9. Yanli Zhang, Yulin Zhang, Ye Lei, Junrong Wu, Yiyuan Kang, Shuo Zheng, Longquan Shao. (2023) MDM2 upregulation induces mitophagy deficiency via Mic60 ubiquitination in fetal microglial inflammation and consequently neuronal DNA damage caused by exposure to ZnO-NPs during pregnancy. JOURNAL OF HAZARDOUS MATERIALS, 457 (131750). [PMID:37315416] |
10. Haili Xiao, Chao Wei, Huiying Liu, Zhiqiang Li, Cihua Zheng, Jun Luo. (2023) Lentinan alleviates sciatic nerve injury by promoting autophagy to remove myelin fragments. PHYTOTHERAPY RESEARCH, [PMID:37165703] |
11. Xin Chang, Chang Liu, Yu-Mo Han, Qiu-Ling Li, Bin Guo, Hu-Lin Jiang. (2023) Efficient transfected liposomes co-loaded with pNrf2 and pirfenidone improves safe delivery for enhanced pulmonary fibrosis reversion. Molecular Therapy-Nucleic Acids, 32 (415-431). [PMID:37159604] |
12. Shi Hanqiang, Xiong Lie, Yan Guang, Du Shuqin, Liu Jie, Shi Yanbo. (2023) Susceptibility of cervical cancer to dihydroartemisinin-induced ferritinophagy-dependent ferroptosis. Frontiers in Molecular Biosciences, 10 [PMID:37065442] |
13. Jinzhe Li, Chuyun Fu, Qiufeng Lin, Tao Zeng, Da Wang, Xinwen Huang, Shuang Song, Cong Li, Feilong Dong. (2023) Fe(VI) activation system mediated by a solar-driven TiO2 nanotubes electrode for CLQ degradation: Performances, mechanisms and pathways. JOURNAL OF HAZARDOUS MATERIALS, 452 (131274). [PMID:36989796] |
14. T Wang, Q Wang, G Pan, G Jia, X Li, C Wang, L Zhang, C Zuo. (2023) ASIC1a involves the acid-mediated activation of pancreatic stellate cells associated with autophagy induction. PHYSIOLOGICAL RESEARCH, 72 (1): (49-57). [PMID:36545882] |
15. Yingbo Jia, Jing Hu, Chaojie Zhu, Zijing Li, Xinyu Yang, Ruitian Liu, Linghui Zeng, Lingxiao Zhang. (2023) Engineered NanoAlum from aluminum turns cold tumor hot for potentiating cancer metalloimmunotherapy. JOURNAL OF CONTROLLED RELEASE, 354 (770). [PMID:36702259] |
16. Xu Chi, Jiang Shuyun, Ma Xingyu, Jiang Zeyong, Pan Youguang, Li Xiang, Zhang Liying, Zhou Hao, Chen Shen, Xing Xiumei, Chen Liping, Fu Wenfan, Wang Qing, Chen Wen, Li Daochuan. (2023) CRISPR-based DNA methylation editing of NNT rescues the cisplatin resistance of lung cancer cells by reducing autophagy. ARCHIVES OF TOXICOLOGY, 97 (2): (441-456). [PMID:36336710] |
17. Shiqi Zhu, Haimei Wen, Wenling Wang, Yong Chen, Fengmei Han, Wentao Cai. (2023) Anti-hepatitis B virus activity of lithospermic acid, a polyphenol from Salvia miltiorrhiza, in vitro and in vivo by autophagy regulation. JOURNAL OF ETHNOPHARMACOLOGY, 302 (115896). [PMID:36334815] |
18. Xiaonan Chen, Yiqing Zou, Shuqi Zhang, Pengchao Fang, Shuxuan Li, Pengyu Li, Yingying Sun, Gang Yuan, Haiyan Hu. (2022) Multi-functional vesicles improve Helicobacter pylori eradication by a comprehensive strategy based on complex pathological microenvironment. Acta Pharmaceutica Sinica B, 12 (3498). [PMID:36176916] |
19. Yi Wang, Jingwen Xu, Yihai Wang, Limin Xiang, Xiangjiu He. (2022) S-20, a steroidal saponin from the berries of black nightshade, exerts anti-multidrug resistance activity in K562/ADR cells through autophagic cell death and ERK activation. Food & Function, 13 (4): (2200-2215). [PMID:35119449] |
20. Li Li Li, Wen Yi Lv, Yao Wang, Yuan Fang Li, Chun Mei Li, Cheng Zhi Huang. (2021) DNA Logic Nanodevices for Real-Time Monitoring of ATP in Lysosomes. ANALYTICAL CHEMISTRY, 93 (46): (15331–15339). [PMID:34756034] |
21. Xiao-Qiong Li, Xiang-Nan Liu, Yi-Lei Jia, Xi-Liang Luo, Hong-Yuan Chen, Jing-Juan Xu. (2021) Dual Recognition DNA Triangular Prism Nanoprobe: Toward the Relationship between K+ and pH in Lysosomes. ANALYTICAL CHEMISTRY, 93 (44): (14892–14899). [PMID:34709789] |
22. Miaomiao Qi, Xiang Liu, Ying Zhou, Haoyu Wang, Ying Zhao, Jing Ren, Jin Xiang. (2021) Berberine Inhibits MDA-MB-231 Cells as an Agonist of G Protein-Coupled Estrogen Receptor 1. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22 (21): (11466). [PMID:34768896] |
23. Shaohong Fang,Xin Wan,Xiaoyi Zou,Song Sun,Xinran Hao,Chenchen Liang,Zhenming Zhang,Fangni Zhang,Bo Sun,Hulun Li,Bo Yu. (2021-01-20) Arsenic trioxide induces macrophage autophagy and atheroprotection by regulating ROS-dependent TFEB nuclear translocation and AKT/mTOR pathway.. Cell death & disease, 12 ((1)): (88-88). [PMID:33462182] |
1. Xijuan Chao, Dezhi Yao, Chuxuan Chen, Zhiguo Sheng, Benzhan Zhu. (2024) Tetrabromobisphenol A induces neuronal cytotoxicity by inhibiting PINK1-Parkin-mediated mitophagy via upregulating ATF3 expression. SCIENCE OF THE TOTAL ENVIRONMENT, 912 (169175). [PMID:38065503] |
2. Xiaolin Zhang, Zhen Dong, Yuanmiao Yang, Chaolong Liu, Jisheng Li, Wenli Sun, Yikang Zhu, Yang Shen, Zhi Wang, Muhan Lü, Hongjuan Cui. (2023) Morusinol Extracted from Morus alba Inhibits Cell Proliferation and Induces Autophagy via FOXO3a Nuclear Accumulation-Mediated Cholesterol Biosynthesis Obstruction in Colorectal Cancer. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, (19): [PMID:37870273] |
3. Dan Yuan, Qi Li, Qibo Zhang, Feibai Zhou, Qiangzhong Zhao, Mouming Zhao. (2024) Enhanced curcumin transportation across epithelial barrier by mucus-permeable soy protein nanoparticles-mediated dual transcytosis pathways. FOOD CHEMISTRY, 437 (137771). [PMID:37897825] |
4. Yiqian Zhang, Qianrui Huang, Qisi Xu, Chengsen Jia, Yong Xia. (2023) Pimavanserin tartrate induces apoptosis and cytoprotective autophagy and synergizes with chemotherapy on triple negative breast cancer. BIOMEDICINE & PHARMACOTHERAPY, 168 (8): (115665). [PMID:37832400] |
5. Liu Jin, Chen Yuqian, Chen Huan, Wang Yan, Li Danyang, Zhang Qianqian, Chai Limin, Qiu Yuanjie, Zhang Jia, Shen Nirui, Wang Qingting, Wang Jian, Li Manxiang. (2023) Macrophage migration inhibitory factor exacerbates asthmatic airway remodeling via dynamin-related protein 1-mediated autophagy activation. RESPIRATORY RESEARCH, 24 (1): (1-14). [PMID:37674165] |
6. Daxiu Li, Feng Qiu, Ruo Yuan, Yun Xiang. (2023) Multiplexed and amplified electrochemical aptasensor for sensitive assay of piperaquine and mefloquine. SENSORS AND ACTUATORS B-CHEMICAL, 395 (134483). [PMID:32499645] |
7. Peixin Wang, Chenqiong Zhao, Hanjing Zhou, Xiaona Huang, Hanqi Ying, Songying Zhang, Yibin Pan, Haiyan Zhu. (2023) Dysregulation of Histone Deacetylases Inhibits Trophoblast Growth during Early Placental Development Partially through TFEB-Dependent Autophagy-Lysosomal Pathway. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24 (15): (11899). [PMID:37569278] |
8. Zhe Chen, Jia-Yu Zhang, Qian Jiang, Yang-Yang Bao, Zhi-Mei Li, Shui-Hong Zhou, Jiang-Tao Zhong, Zi-Ming Fu, Zai-Zai Cao, Jun Fan, Hong-Tian Yao. (2023) Pepsin Increases the Proliferation of Vocal Cord Leukoplakia Epithelial Cells by Inducing Autophagy. OTOLARYNGOLOGY-HEAD AND NECK SURGERY, [PMID:37264983] |
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