Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
SKU | Size | Availability | Price | Qty |
---|---|---|---|---|
C129284-5g | 5g | In stock | $16.90 | |
C129284-25g | 25g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $62.90 | |
C129284-100g | 100g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $155.90 | |
C129284-500g | 500g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $541.90 |
Antimalarial; apoptosis and autophagy inhibitor
Synonyms | Chloroquine diphosphate | Chloroquine phosphate | 50-63-5 | Aralen phosphate | Resochin | Arechin | Avloclor | Chingamin phosphate | Tanakan | Chloroquine diphosphate salt | Quingamine | Delagil | Miniquine | Tanakene | Chloroquine bis(phosphate) | Chlorochin diphosphate | Chloroquine ( |
---|---|
Specifications & Purity | ≥99% |
Biochemical and Physiological Mechanisms | Antimalarial agent. Inhibits tumor cell growth and metastasis and induces apoptosis in vitro . Binds to Fe(II)-protoporphyrin IX (FP) to form FP-chloroquine complex resulting in cell lysis and parasite cell autodigestion. |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Action Type | INHIBITOR |
Mechanism of action | Ferriprotoporphyrin IX inhibitor |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Chloroquine Phosphate is an antimalarial agent that has been discovered to have a distinct affinity for melanin. Used in the treatment of arthritis, malaria and Lupus. Chloroquine Phosphate is a substrate of MRP. |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
IUPAC Name | 4-N-(7-chloroquinolin-4-yl)-1-N,1-N-diethylpentane-1,4-diamine;phosphoric acid |
---|---|
INCHI | InChI=1S/C18H26ClN3.2H3O4P/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18;2*1-5(2,3)4/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21);2*(H3,1,2,3,4) |
InChi Key | QKICWELGRMTQCR-UHFFFAOYSA-N |
Canonical SMILES | CCN(CC)CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl.OP(=O)(O)O.OP(=O)(O)O |
Isomeric SMILES | CCN(CC)CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl.OP(=O)(O)O.OP(=O)(O)O |
WGK Germany | 3 |
RTECS | VB2450000 |
PubChem CID | 64927 |
Molecular Weight | 515.86 |
Beilstein | 4223142 |
Reaxy-Rn | 4223142 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
F2417079 | Certificate of Analysis | Jun 20, 2024 | C129284 |
C2414239 | Certificate of Analysis | Feb 29, 2024 | C129284 |
C2414240 | Certificate of Analysis | Feb 29, 2024 | C129284 |
C2414241 | Certificate of Analysis | Feb 29, 2024 | C129284 |
A2418058 | Certificate of Analysis | Dec 25, 2023 | C129284 |
L2321270 | Certificate of Analysis | Dec 25, 2023 | C129284 |
B2223658 | Certificate of Analysis | Dec 25, 2023 | C129284 |
B2223763 | Certificate of Analysis | Dec 25, 2023 | C129284 |
E2015085 | Certificate of Analysis | Apr 13, 2022 | C129284 |
G2326070 | Certificate of Analysis | Apr 13, 2022 | C129284 |
B2223765 | Certificate of Analysis | Dec 30, 2021 | C129284 |
B2223776 | Certificate of Analysis | Dec 30, 2021 | C129284 |
B2223785 | Certificate of Analysis | Dec 30, 2021 | C129284 |
K2324056 | Certificate of Analysis | Dec 30, 2021 | C129284 |
Solubility | DMSO <1 mg/mL Water 100 mg/mL Ethanol <1 mg/mL |
---|---|
Sensitivity | Light sensitive |
Melt Point(°C) | 199°C |
Pictogram(s) | GHS08, GHS07 |
---|---|
Signal | Danger |
Hazard Statements | H373:Causes damage to organs through prolonged or repeated exposure H302:Harmful if swallowed H360:May damage fertility or the unborn child |
Precautionary Statements | P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
RTECS | VB2450000 |
Reaxy-Rn | 4223142 |
Merck Index | 2163 |
1. Shengchao Hu, Jian Zhao, Shangbiao Fang, Kehui Guo, Weixiao Qi, Huijuan Liu. (2024) Neurotoxic effects of chloroquine and its main transformation product formed after chlorination. SCIENCE OF THE TOTAL ENVIRONMENT, 908 (168043). [PMID:37898196] |
2. Liu Jin, Chen Yuqian, Chen Huan, Wang Yan, Li Danyang, Zhang Qianqian, Chai Limin, Qiu Yuanjie, Zhang Jia, Shen Nirui, Wang Qingting, Wang Jian, Li Manxiang. (2023) Macrophage migration inhibitory factor exacerbates asthmatic airway remodeling via dynamin-related protein 1-mediated autophagy activation. RESPIRATORY RESEARCH, 24 (1): (1-14). [PMID:37674165] |
3. Mingqiao Li, Hedan Xu, Nan Zhao, Liangjun Zhang, Haihan Xia, Xiaoxun Zhang, Qiao Li, Min Liao, Qiong Pan, Zeng Yi, Jin Chai. (2023) Hepatocyte-targeted hyaluronic acid-polyethyleneimine conjugates for acute liver injury therapy by ROS elimination and inflammation modulation. MATERIALS & DESIGN, 233 (112212). [PMID:] |
4. Qiang Yang, Longgang Chu, Tongliang Wu, Yiyi Zhou, Cun Liu, Long Cang, Guodong Fang, Peixin Cui, Yujun Wang. (2023) Investigation of dual-functional carbon cathode catalysts from agricultural wastes in the heterogeneous electro-Fenton process. APPLIED CATALYSIS B-ENVIRONMENTAL, 337 (123018). [PMID:] |
5. Shengchao Hu, Shangbiao Fang, Jian Zhao, Guowei Wang, Weixiao Qi, Gong Zhang, Cunrui Huang, Jiuhui Qu, Huijuan Liu. (2023) Toxicity Evaluation and Effect-Based Identification of Chlorine Disinfection Products of the Anti-COVID-19 Drug Chloroquine Phosphate. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 57 (21): (7913–7923). [PMID:37188658] |
6. Hongwei Sun, Jinjin He, Yucan Liu, Xianguo Ji, Gang Wang, Xiaoyong Yang, Yanxiang Zhang. (2023) Removal Performance and Mechanism of Emerging Pollutant Chloroquine Phosphate from Water by Iron and Magnesium Co-Modified Rape Straw Biochar. MOLECULES, 28 (8): (3290). [PMID:37110522] |
7. Jinchao Xing, Chen Hu, Siqi Che, Yixin Lan, Lihong Huang, Lele Liu, Youqin Yin, Huanan Li, Ming Liao, Wenbao Qi. (2023) USP1-Associated Factor 1 Modulates Japanese Encephalitis Virus Replication by Governing Autophagy and Interferon-Stimulated Genes. Microbiology Spectrum, 11 (3): [PMID:36988464] |
8. Xueli Hu, Yuanhang Zhou, Yingying Zhou, Yun Bai, Ruiting Chang, Peng Lu, Zhi Zhang. (2023) Insight into core -shell microporous zinc silicate adsorbent to eliminate antibiotics in aquatic environment under the COVID-19 pandemic. Journal of Cleaner Production, 383 (135416). [PMID:36504484] |
9. Wang Junqi, Jing Xian, Hua Lizhong, Zheng Yuling, Hu Shiheng, Xiao Jing, Guo Dawei, Wu Wenda, Ji Hui, Peng Lin, Jiang Shanxiang, Gao Xiuge. (2022) Hypertension related toxicity of chloroquine explains its failure against COVID-19: Based on rat model. Frontiers in Pharmacology, 13 [PMID:36532753] |
10. Xinqi Zheng, Pengran Guo, Yue Zhang, Jingwei Xu, Jian Sun, Yongqian Lei. (2022) An ultra sensitive and rapid SERS detection method based on vortex aggregation enhancement effect for anti-infective drug residues detection in water. ANALYTICA CHIMICA ACTA, 1235 (340539). [PMID:36368827] |
11. Qinying Liu, Yi Yang, Miaomiao Cheng, Fangting Cheng, Shanshan Chen, Qiuhong Zheng, Yang Sun, Li Chen. (2022) The marine natural product, dicitrinone B, induces apoptosis through autophagy blockade in breast cancer. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 50 (4): (1-13). [PMID:36052845] |
12. Mengxue Yang, Ruixian Wu, Shengshuai Cao, Yanwei Li, Sisi Huo, Wei Wang, Zhen Hu, Xing Xu. (2023) Versatile pathways for oxidating organics via peroxymonosulfate activation by different single atom catalysts confining with Fe–N4 or Cu–N4 sites. CHEMICAL ENGINEERING JOURNAL, 451 (138606). [PMID:] |
1. Si L et al.. (2021) A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics.. Nat Biomed Eng, 5 (8): (815-829). [PMID:33941899] |
2. Prieto P et al.. (2015) Activation of autophagy in macrophages by pro-resolving lipid mediators.. Autophagy, 11 (10): (1729-44). [PMID:26506892] |
3. Xu S et al.. (2019) Ai-lncRNA EGOT enhancing autophagy sensitizes paclitaxel cytotoxicity via upregulation of ITPR1 expression by RNA-RNA and RNA-protein interactions in human cancer.. Mol Cancer, 18 (89). [PMID:30999914] |
4. Lotsberg ML et al.. (2020) AXL Targeting Abrogates Autophagic Flux and Induces Immunogenic Cell Death in Drug-Resistant Cancer Cells.. J Thorac Oncol, 15 (6): (973-999). [PMID:32018052] |
5. Eloranta K et al.. (2020) Chloroquine Triggers Cell Death and Inhibits PARPs in Cell Models of Aggressive Hepatoblastoma.. Front Oncol, 10 (1138). [PMID:32766148] |
6. Alsamri H et al.. (2022) Carnosol Induces p38-Mediated ER Stress Response and Autophagy in Human Breast Cancer Cells.. Front Oncol, 12 (911615). [PMID:35712465] |
7. Alsamri H et al.. (2021) Carnosol Is a Novel Inhibitor of p300 Acetyltransferase in Breast Cancer.. Front Oncol, 11 (664403). [PMID:34055630] |
8. Goyal S et al.. (2020) Inhibition of in vitro Ebola infection by anti-parasitic quinoline derivatives.. F1000Res, 9 (268). [PMID:32528661] |
9. Xiang C et al.. (2021) Intestinal microbiota modulates adrenomedullary response through Nod1 sensing in chromaffin cells.. iScience, 24 (8): (102849). [PMID:34381974] |
10. Frietze KK et al.. (2022) Lipotoxicity reduces DDX58/Rig-1 expression and activity leading to impaired autophagy and cell death.. Autophagy, 18 (142-160). [PMID:33966599] |
11. De Waele J et al.. (2018) Poly(I:C) primes primary human glioblastoma cells for an immune response invigorated by PD-L1 blockade.. Oncoimmunology, 7 (3): (e1407899). [PMID:29399410] |
12. Shengchao Hu, Jian Zhao, Shangbiao Fang, Kehui Guo, Weixiao Qi, Huijuan Liu. (2024) Neurotoxic effects of chloroquine and its main transformation product formed after chlorination. SCIENCE OF THE TOTAL ENVIRONMENT, 908 (168043). [PMID:37898196] |
13. Liu Jin, Chen Yuqian, Chen Huan, Wang Yan, Li Danyang, Zhang Qianqian, Chai Limin, Qiu Yuanjie, Zhang Jia, Shen Nirui, Wang Qingting, Wang Jian, Li Manxiang. (2023) Macrophage migration inhibitory factor exacerbates asthmatic airway remodeling via dynamin-related protein 1-mediated autophagy activation. RESPIRATORY RESEARCH, 24 (1): (1-14). [PMID:37674165] |
14. Mingqiao Li, Hedan Xu, Nan Zhao, Liangjun Zhang, Haihan Xia, Xiaoxun Zhang, Qiao Li, Min Liao, Qiong Pan, Zeng Yi, Jin Chai. (2023) Hepatocyte-targeted hyaluronic acid-polyethyleneimine conjugates for acute liver injury therapy by ROS elimination and inflammation modulation. MATERIALS & DESIGN, 233 (112212). [PMID:] |
15. Qiang Yang, Longgang Chu, Tongliang Wu, Yiyi Zhou, Cun Liu, Long Cang, Guodong Fang, Peixin Cui, Yujun Wang. (2023) Investigation of dual-functional carbon cathode catalysts from agricultural wastes in the heterogeneous electro-Fenton process. APPLIED CATALYSIS B-ENVIRONMENTAL, 337 (123018). [PMID:] |
16. Shengchao Hu, Shangbiao Fang, Jian Zhao, Guowei Wang, Weixiao Qi, Gong Zhang, Cunrui Huang, Jiuhui Qu, Huijuan Liu. (2023) Toxicity Evaluation and Effect-Based Identification of Chlorine Disinfection Products of the Anti-COVID-19 Drug Chloroquine Phosphate. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 57 (21): (7913–7923). [PMID:37188658] |
17. Hongwei Sun, Jinjin He, Yucan Liu, Xianguo Ji, Gang Wang, Xiaoyong Yang, Yanxiang Zhang. (2023) Removal Performance and Mechanism of Emerging Pollutant Chloroquine Phosphate from Water by Iron and Magnesium Co-Modified Rape Straw Biochar. MOLECULES, 28 (8): (3290). [PMID:37110522] |
18. Jinchao Xing, Chen Hu, Siqi Che, Yixin Lan, Lihong Huang, Lele Liu, Youqin Yin, Huanan Li, Ming Liao, Wenbao Qi. (2023) USP1-Associated Factor 1 Modulates Japanese Encephalitis Virus Replication by Governing Autophagy and Interferon-Stimulated Genes. Microbiology Spectrum, 11 (3): [PMID:36988464] |
19. Xueli Hu, Yuanhang Zhou, Yingying Zhou, Yun Bai, Ruiting Chang, Peng Lu, Zhi Zhang. (2023) Insight into core -shell microporous zinc silicate adsorbent to eliminate antibiotics in aquatic environment under the COVID-19 pandemic. Journal of Cleaner Production, 383 (135416). [PMID:36504484] |
20. Wang Junqi, Jing Xian, Hua Lizhong, Zheng Yuling, Hu Shiheng, Xiao Jing, Guo Dawei, Wu Wenda, Ji Hui, Peng Lin, Jiang Shanxiang, Gao Xiuge. (2022) Hypertension related toxicity of chloroquine explains its failure against COVID-19: Based on rat model. Frontiers in Pharmacology, 13 [PMID:36532753] |
21. Xinqi Zheng, Pengran Guo, Yue Zhang, Jingwei Xu, Jian Sun, Yongqian Lei. (2022) An ultra sensitive and rapid SERS detection method based on vortex aggregation enhancement effect for anti-infective drug residues detection in water. ANALYTICA CHIMICA ACTA, 1235 (340539). [PMID:36368827] |
22. Qinying Liu, Yi Yang, Miaomiao Cheng, Fangting Cheng, Shanshan Chen, Qiuhong Zheng, Yang Sun, Li Chen. (2022) The marine natural product, dicitrinone B, induces apoptosis through autophagy blockade in breast cancer. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 50 (4): (1-13). [PMID:36052845] |
23. Mengxue Yang, Ruixian Wu, Shengshuai Cao, Yanwei Li, Sisi Huo, Wei Wang, Zhen Hu, Xing Xu. (2023) Versatile pathways for oxidating organics via peroxymonosulfate activation by different single atom catalysts confining with Fe–N4 or Cu–N4 sites. CHEMICAL ENGINEERING JOURNAL, 451 (138606). [PMID:] |