Chloroquine Phosphate - ≥99%, high purity , Ferriprotoporphyrin IX inhibitor, CAS No.50-63-5, Ferriprotoporphyrin IX inhibitor

12 Citations
  • ≥99%
Item Number
C129284
Grouped product items
SKUSizeAvailabilityPrice Qty
C129284-5g
5g
In stock
$16.90
C129284-25g
25g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$62.90
C129284-100g
100g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$155.90
C129284-500g
500g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$541.90

Antimalarial; apoptosis and autophagy inhibitor

Basic Description

SynonymsChloroquine diphosphate | Chloroquine phosphate | 50-63-5 | Aralen phosphate | Resochin | Arechin | Avloclor | Chingamin phosphate | Tanakan | Chloroquine diphosphate salt | Quingamine | Delagil | Miniquine | Tanakene | Chloroquine bis(phosphate) | Chlorochin diphosphate | Chloroquine (
Specifications & Purity≥99%
Biochemical and Physiological MechanismsAntimalarial agent. Inhibits tumor cell growth and metastasis and induces apoptosis in vitro . Binds to Fe(II)-protoporphyrin IX (FP) to form FP-chloroquine complex resulting in cell lysis and parasite cell autodigestion.
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
Action TypeINHIBITOR
Mechanism of actionFerriprotoporphyrin IX inhibitor
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Chloroquine Phosphate is an antimalarial agent that has been discovered to have a distinct affinity for melanin. Used in the treatment of arthritis, malaria and Lupus. Chloroquine Phosphate is a substrate of MRP.
An antimalarial compound

Associated Targets(Human)

CYP2D6 Tclin Cytochrome P450 2D6 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CYP3A4 Tclin Cytochrome P450 3A4 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
HSD17B10 Tchem 3-hydroxyacyl-CoA dehydrogenase type-2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GALC Tbio Galactocerebrosidase (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
MAPT Tclin Microtubule-associated protein tau (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
KDM4E Tchem Lysine-specific demethylase 4E (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
KCNH2 Tclin HERG (29587 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
K562 (73714 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MCF7 (126967 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MDA-MB-468 (9477 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MRC5 (9203 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cell line (371 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HepG2 (196354 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NCI-H460 (60772 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KB (17409 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HeLa (62764 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MDA-MB-231 (73002 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HSD17B10 Tchem Endoplasmic reticulum-associated amyloid beta-peptide-binding protein (20669 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DNA (187 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
184B5 (172 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Histidine-rich protein (528 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Galc Galactocerebrosidase (11 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Trypanosoma brucei brucei (13300 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Entamoeba histolytica (2676 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium berghei (192651 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium yoelii (6656 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHO (4503 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Vero (26788 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MAC15A (81 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Calf thymus DNA (4845 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Ferriprotoporphyrin IX (165 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
botA Botulinum neurotoxin type A (1303 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mapt Microtubule-associated protein tau (6 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
nfo Endonuclease 4 (425 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name 4-N-(7-chloroquinolin-4-yl)-1-N,1-N-diethylpentane-1,4-diamine;phosphoric acid
INCHI InChI=1S/C18H26ClN3.2H3O4P/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18;2*1-5(2,3)4/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21);2*(H3,1,2,3,4)
InChi Key QKICWELGRMTQCR-UHFFFAOYSA-N
Canonical SMILES CCN(CC)CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl.OP(=O)(O)O.OP(=O)(O)O
Isomeric SMILES CCN(CC)CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl.OP(=O)(O)O.OP(=O)(O)O
WGK Germany 3
RTECS VB2450000
PubChem CID 64927
Molecular Weight 515.86
Beilstein 4223142
Reaxy-Rn 4223142

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

14 results found

Lot NumberCertificate TypeDateItem
F2417079Certificate of AnalysisJun 20, 2024 C129284
C2414239Certificate of AnalysisFeb 29, 2024 C129284
C2414240Certificate of AnalysisFeb 29, 2024 C129284
C2414241Certificate of AnalysisFeb 29, 2024 C129284
A2418058Certificate of AnalysisDec 25, 2023 C129284
L2321270Certificate of AnalysisDec 25, 2023 C129284
B2223658Certificate of AnalysisDec 25, 2023 C129284
B2223763Certificate of AnalysisDec 25, 2023 C129284
E2015085Certificate of AnalysisApr 13, 2022 C129284
G2326070Certificate of AnalysisApr 13, 2022 C129284
B2223765Certificate of AnalysisDec 30, 2021 C129284
B2223776Certificate of AnalysisDec 30, 2021 C129284
B2223785Certificate of AnalysisDec 30, 2021 C129284
K2324056Certificate of AnalysisDec 30, 2021 C129284

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Chemical and Physical Properties

SolubilityDMSO <1 mg/mL Water 100 mg/mL Ethanol <1 mg/mL
SensitivityLight sensitive
Melt Point(°C)199°C

Safety and Hazards(GHS)

Pictogram(s) GHS08,   GHS07
Signal Danger
Hazard Statements

H373:Causes damage to organs through prolonged or repeated exposure

H302:Harmful if swallowed

H360:May damage fertility or the unborn child

Precautionary Statements

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P260:Do not breathe dust/fume/gas/mist/vapors/spray.

P270:Do not eat, drink or smoke when using this product.

P330:Rinse mouth.

P203:Obtain, read and follow all safety instructions before use.

P301+P317:IF SWALLOWED: Get medical help.

P318:if exposed or concerned, get medical advice.

P319:Get medical help if you feel unwell.

WGK Germany 3
RTECS VB2450000
Reaxy-Rn 4223142
Merck Index 2163

Related Documents

Citations of This Product

1. Shengchao Hu, Jian Zhao, Shangbiao Fang, Kehui Guo, Weixiao Qi, Huijuan Liu.  (2024)  Neurotoxic effects of chloroquine and its main transformation product formed after chlorination.  SCIENCE OF THE TOTAL ENVIRONMENT,  908  (168043).  [PMID:37898196]
2. Liu Jin, Chen Yuqian, Chen Huan, Wang Yan, Li Danyang, Zhang Qianqian, Chai Limin, Qiu Yuanjie, Zhang Jia, Shen Nirui, Wang Qingting, Wang Jian, Li Manxiang.  (2023)  Macrophage migration inhibitory factor exacerbates asthmatic airway remodeling via dynamin-related protein 1-mediated autophagy activation.  RESPIRATORY RESEARCH,  24  (1): (1-14).  [PMID:37674165]
3. Mingqiao Li, Hedan Xu, Nan Zhao, Liangjun Zhang, Haihan Xia, Xiaoxun Zhang, Qiao Li, Min Liao, Qiong Pan, Zeng Yi, Jin Chai.  (2023)  Hepatocyte-targeted hyaluronic acid-polyethyleneimine conjugates for acute liver injury therapy by ROS elimination and inflammation modulation.  MATERIALS & DESIGN,  233  (112212).  [PMID:]
4. Qiang Yang, Longgang Chu, Tongliang Wu, Yiyi Zhou, Cun Liu, Long Cang, Guodong Fang, Peixin Cui, Yujun Wang.  (2023)  Investigation of dual-functional carbon cathode catalysts from agricultural wastes in the heterogeneous electro-Fenton process.  APPLIED CATALYSIS B-ENVIRONMENTAL,  337  (123018).  [PMID:]
5. Shengchao Hu, Shangbiao Fang, Jian Zhao, Guowei Wang, Weixiao Qi, Gong Zhang, Cunrui Huang, Jiuhui Qu, Huijuan Liu.  (2023)  Toxicity Evaluation and Effect-Based Identification of Chlorine Disinfection Products of the Anti-COVID-19 Drug Chloroquine Phosphate.  ENVIRONMENTAL SCIENCE & TECHNOLOGY,  57  (21): (7913–7923).  [PMID:37188658]
6. Hongwei Sun, Jinjin He, Yucan Liu, Xianguo Ji, Gang Wang, Xiaoyong Yang, Yanxiang Zhang.  (2023)  Removal Performance and Mechanism of Emerging Pollutant Chloroquine Phosphate from Water by Iron and Magnesium Co-Modified Rape Straw Biochar.  MOLECULES,  28  (8): (3290).  [PMID:37110522]
7. Jinchao Xing, Chen Hu, Siqi Che, Yixin Lan, Lihong Huang, Lele Liu, Youqin Yin, Huanan Li, Ming Liao, Wenbao Qi.  (2023)  USP1-Associated Factor 1 Modulates Japanese Encephalitis Virus Replication by Governing Autophagy and Interferon-Stimulated Genes.  Microbiology Spectrum,  11  (3):   [PMID:36988464]
8. Xueli Hu, Yuanhang Zhou, Yingying Zhou, Yun Bai, Ruiting Chang, Peng Lu, Zhi Zhang.  (2023)  Insight into core -shell microporous zinc silicate adsorbent to eliminate antibiotics in aquatic environment under the COVID-19 pandemic.  Journal of Cleaner Production,  383  (135416).  [PMID:36504484]
9. Wang Junqi, Jing Xian, Hua Lizhong, Zheng Yuling, Hu Shiheng, Xiao Jing, Guo Dawei, Wu Wenda, Ji Hui, Peng Lin, Jiang Shanxiang, Gao Xiuge.  (2022)  Hypertension related toxicity of chloroquine explains its failure against COVID-19: Based on rat model.  Frontiers in Pharmacology,  13    [PMID:36532753]
10. Xinqi Zheng, Pengran Guo, Yue Zhang, Jingwei Xu, Jian Sun, Yongqian Lei.  (2022)  An ultra sensitive and rapid SERS detection method based on vortex aggregation enhancement effect for anti-infective drug residues detection in water.  ANALYTICA CHIMICA ACTA,  1235  (340539).  [PMID:36368827]
11. Qinying Liu, Yi Yang, Miaomiao Cheng, Fangting Cheng, Shanshan Chen, Qiuhong Zheng, Yang Sun, Li Chen.  (2022)  The marine natural product, dicitrinone B, induces apoptosis through autophagy blockade in breast cancer.  INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,  50  (4): (1-13).  [PMID:36052845]
12. Mengxue Yang, Ruixian Wu, Shengshuai Cao, Yanwei Li, Sisi Huo, Wei Wang, Zhen Hu, Xing Xu.  (2023)  Versatile pathways for oxidating organics via peroxymonosulfate activation by different single atom catalysts confining with Fe–N4 or Cu–N4 sites.  CHEMICAL ENGINEERING JOURNAL,  451  (138606).  [PMID:]

References

1. Si L et al..  (2021)  A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics..  Nat Biomed Eng,  (8): (815-829).  [PMID:33941899]
2. Prieto P et al..  (2015)  Activation of autophagy in macrophages by pro-resolving lipid mediators..  Autophagy,  11  (10): (1729-44).  [PMID:26506892]
3. Xu S et al..  (2019)  Ai-lncRNA EGOT enhancing autophagy sensitizes paclitaxel cytotoxicity via upregulation of ITPR1 expression by RNA-RNA and RNA-protein interactions in human cancer..  Mol Cancer,  18  (89).  [PMID:30999914]
4. Lotsberg ML et al..  (2020)  AXL Targeting Abrogates Autophagic Flux and Induces Immunogenic Cell Death in Drug-Resistant Cancer Cells..  J Thorac Oncol,  15  (6): (973-999).  [PMID:32018052]
5. Eloranta K et al..  (2020)  Chloroquine Triggers Cell Death and Inhibits PARPs in Cell Models of Aggressive Hepatoblastoma..  Front Oncol,  10  (1138).  [PMID:32766148]
6. Alsamri H et al..  (2022)  Carnosol Induces p38-Mediated ER Stress Response and Autophagy in Human Breast Cancer Cells..  Front Oncol,  12  (911615).  [PMID:35712465]
7. Alsamri H et al..  (2021)  Carnosol Is a Novel Inhibitor of p300 Acetyltransferase in Breast Cancer..  Front Oncol,  11  (664403).  [PMID:34055630]
8. Goyal S et al..  (2020)  Inhibition of in vitro Ebola infection by anti-parasitic quinoline derivatives..  F1000Res,  (268).  [PMID:32528661]
9. Xiang C et al..  (2021)  Intestinal microbiota modulates adrenomedullary response through Nod1 sensing in chromaffin cells..  iScience,  24  (8): (102849).  [PMID:34381974]
10. Frietze KK et al..  (2022)  Lipotoxicity reduces DDX58/Rig-1 expression and activity leading to impaired autophagy and cell death..  Autophagy,  18  (142-160).  [PMID:33966599]
11. De Waele J et al..  (2018)  Poly(I:C) primes primary human glioblastoma cells for an immune response invigorated by PD-L1 blockade..  Oncoimmunology,  (3): (e1407899).  [PMID:29399410]
12. Shengchao Hu, Jian Zhao, Shangbiao Fang, Kehui Guo, Weixiao Qi, Huijuan Liu.  (2024)  Neurotoxic effects of chloroquine and its main transformation product formed after chlorination.  SCIENCE OF THE TOTAL ENVIRONMENT,  908  (168043).  [PMID:37898196]
13. Liu Jin, Chen Yuqian, Chen Huan, Wang Yan, Li Danyang, Zhang Qianqian, Chai Limin, Qiu Yuanjie, Zhang Jia, Shen Nirui, Wang Qingting, Wang Jian, Li Manxiang.  (2023)  Macrophage migration inhibitory factor exacerbates asthmatic airway remodeling via dynamin-related protein 1-mediated autophagy activation.  RESPIRATORY RESEARCH,  24  (1): (1-14).  [PMID:37674165]
14. Mingqiao Li, Hedan Xu, Nan Zhao, Liangjun Zhang, Haihan Xia, Xiaoxun Zhang, Qiao Li, Min Liao, Qiong Pan, Zeng Yi, Jin Chai.  (2023)  Hepatocyte-targeted hyaluronic acid-polyethyleneimine conjugates for acute liver injury therapy by ROS elimination and inflammation modulation.  MATERIALS & DESIGN,  233  (112212).  [PMID:]
15. Qiang Yang, Longgang Chu, Tongliang Wu, Yiyi Zhou, Cun Liu, Long Cang, Guodong Fang, Peixin Cui, Yujun Wang.  (2023)  Investigation of dual-functional carbon cathode catalysts from agricultural wastes in the heterogeneous electro-Fenton process.  APPLIED CATALYSIS B-ENVIRONMENTAL,  337  (123018).  [PMID:]
16. Shengchao Hu, Shangbiao Fang, Jian Zhao, Guowei Wang, Weixiao Qi, Gong Zhang, Cunrui Huang, Jiuhui Qu, Huijuan Liu.  (2023)  Toxicity Evaluation and Effect-Based Identification of Chlorine Disinfection Products of the Anti-COVID-19 Drug Chloroquine Phosphate.  ENVIRONMENTAL SCIENCE & TECHNOLOGY,  57  (21): (7913–7923).  [PMID:37188658]
17. Hongwei Sun, Jinjin He, Yucan Liu, Xianguo Ji, Gang Wang, Xiaoyong Yang, Yanxiang Zhang.  (2023)  Removal Performance and Mechanism of Emerging Pollutant Chloroquine Phosphate from Water by Iron and Magnesium Co-Modified Rape Straw Biochar.  MOLECULES,  28  (8): (3290).  [PMID:37110522]
18. Jinchao Xing, Chen Hu, Siqi Che, Yixin Lan, Lihong Huang, Lele Liu, Youqin Yin, Huanan Li, Ming Liao, Wenbao Qi.  (2023)  USP1-Associated Factor 1 Modulates Japanese Encephalitis Virus Replication by Governing Autophagy and Interferon-Stimulated Genes.  Microbiology Spectrum,  11  (3):   [PMID:36988464]
19. Xueli Hu, Yuanhang Zhou, Yingying Zhou, Yun Bai, Ruiting Chang, Peng Lu, Zhi Zhang.  (2023)  Insight into core -shell microporous zinc silicate adsorbent to eliminate antibiotics in aquatic environment under the COVID-19 pandemic.  Journal of Cleaner Production,  383  (135416).  [PMID:36504484]
20. Wang Junqi, Jing Xian, Hua Lizhong, Zheng Yuling, Hu Shiheng, Xiao Jing, Guo Dawei, Wu Wenda, Ji Hui, Peng Lin, Jiang Shanxiang, Gao Xiuge.  (2022)  Hypertension related toxicity of chloroquine explains its failure against COVID-19: Based on rat model.  Frontiers in Pharmacology,  13    [PMID:36532753]
21. Xinqi Zheng, Pengran Guo, Yue Zhang, Jingwei Xu, Jian Sun, Yongqian Lei.  (2022)  An ultra sensitive and rapid SERS detection method based on vortex aggregation enhancement effect for anti-infective drug residues detection in water.  ANALYTICA CHIMICA ACTA,  1235  (340539).  [PMID:36368827]
22. Qinying Liu, Yi Yang, Miaomiao Cheng, Fangting Cheng, Shanshan Chen, Qiuhong Zheng, Yang Sun, Li Chen.  (2022)  The marine natural product, dicitrinone B, induces apoptosis through autophagy blockade in breast cancer.  INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,  50  (4): (1-13).  [PMID:36052845]
23. Mengxue Yang, Ruixian Wu, Shengshuai Cao, Yanwei Li, Sisi Huo, Wei Wang, Zhen Hu, Xing Xu.  (2023)  Versatile pathways for oxidating organics via peroxymonosulfate activation by different single atom catalysts confining with Fe–N4 or Cu–N4 sites.  CHEMICAL ENGINEERING JOURNAL,  451  (138606).  [PMID:]

Solution Calculators