Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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SKU | Size | Availability | Price | Qty |
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C287936-5mg | 5mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $133.90 | |
C287936-10mg | 10mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $205.90 | |
C287936-25mg | 25mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $461.90 | |
C287936-50mg | 50mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $860.90 | |
C287936-100mg | 100mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $1,549.90 |
Potent and selective FLT3 inhibitor
Specifications & Purity | ≥98% |
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Biochemical and Physiological Mechanisms | Potent and selective FLT3 inhibitor (IC50= 40 nM). Exhibits >10-fold and 170-fold selectivity for FLT3 over BTK kinase and c-KIT kinase, respectivelyin vitro. Induces apoptosis by arresting cell cycle in G0/G1phasein vitro. Suppresses tumor growth in an A |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Product Description | Product description Potent and selective FLT3 inhibitor |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]-2-(dimethylamino)ethanone |
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INCHI | InChI=1S/C26H29N7O2/c1-31(2)16-22(34)32-14-6-7-19(15-32)33-26-23(25(27)28-17-29-26)24(30-33)18-10-12-21(13-11-18)35-20-8-4-3-5-9-20/h3-5,8-13,17,19H,6-7,14-16H2,1-2H3,(H2,27,28,29)/t19-/m1/s1 |
InChi Key | IZNAFSDUTMZGSF-LJQANCHMSA-N |
Canonical SMILES | CN(C)CC(=O)N1CCCC(C1)N2C3=NC=NC(=C3C(=N2)C4=CC=C(C=C4)OC5=CC=CC=C5)N |
Isomeric SMILES | CN(C)CC(=O)N1CCC[C@H](C1)N2C3=NC=NC(=C3C(=N2)C4=CC=C(C=C4)OC5=CC=CC=C5)N |
PubChem CID | 121513893 |
Molecular Weight | 471.55 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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I2206486 | Certificate of Analysis | Aug 01, 2022 | C287936 |
I2206493 | Certificate of Analysis | Aug 01, 2022 | C287936 |
I2206494 | Certificate of Analysis | Aug 01, 2022 | C287936 |
I2206495 | Certificate of Analysis | Aug 01, 2022 | C287936 |
I2206497 | Certificate of Analysis | Aug 01, 2022 | C287936 |
Solubility | Solvent:1eq. HCl, Max Conc. mg/mL: 47.16, Max Conc. mM: 100; Solvent:DMSO, Max Conc. mg/mL: 47.16, Max Conc. mM: 100 |
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