Click Here for 5% Off Your First Aladdin Purchase!

cholest-5-ene-3β,24(S)-diol - >99%, high purity , CAS No.474-73-7, Agonist of Liver X receptor-α;Agonist of Liver X receptor-β

  • Moligand™
  • ≥99%
Item Number
C130207
Grouped product items
SKUSizeAvailabilityPrice Qty
C130207-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$125.90
C130207-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$484.90
C130207-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$872.90

Endogenous LXR agonist

Basic Description

Synonyms24(S)-hydroxycholesterol|Cerebrosterol|474-73-7|Cholest-5-ene-3,24-diol|(24S)-24-Hydroxycholesterol|24S-hydroxycholesterol|Cerebrosterin|cholest-5-en-3beta,24S-diol|24S-hydroxy-cholesterol|24S-OHC|(24S)-cholest-5-ene-3beta,24-diol|(3S,8S,9S,10R,13R,14S,17
Specifications & PurityMoligand™, ≥99%
Biochemical and Physiological MechanismsEndogenous agonist for LXR (EC 50 values are 4 μM and 3 μM at LXRα and LXRβ respectively). Involved in cholesterol homeostasis. Induces neuronal cell death by necroptosis, a form of programmed necrosis.
Shipped InNormal
GradeMoligand™
Action TypeAGONIST
Mechanism of actionAgonist of Liver X receptor-α;Agonist of Liver X receptor-β
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Associated Targets

RORC Tchem Nuclear receptor ROR-gamma 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

NR1H2 Tchem Oxysterols receptor LXR-beta 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

NR1H3 Tchem Oxysterols receptor LXR-alpha 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GRIN1 Tclin Glutamate receptor ionotropic, NMDA 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name (3S,8S,9S,10R,13R,14S,17R)-17-[(2R,5S)-5-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
INCHI InChI=1S/C27H46O2/c1-17(2)25(29)11-6-18(3)22-9-10-23-21-8-7-19-16-20(28)12-14-26(19,4)24(21)13-15-27(22,23)5/h7,17-18,20-25,28-29H,6,8-16H2,1-5H3/t18-,20+,21+,22-,23+,24+,25+,26+,27-/m1/s1
InChi Key IOWMKBFJCNLRTC-XWXSNNQWSA-N
Canonical SMILES CC(C)C(CCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C)O
Isomeric SMILES C[C@H](CC[C@@H](C(C)C)O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C
PubChem CID 121948
Molecular Weight 402.653

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Related Documents

Solution Calculators