CHR-6494 - ≥98%, high purity , CAS No.1333377-65-3

  • ≥98%
Item Number
C124894
Grouped product items
SKUSizeAvailabilityPrice Qty
C124894-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$49.90
C124894-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$75.90
C124894-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$148.90
C124894-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$273.90
C124894-100mg
100mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$465.90
View related series
Kinase inhibitor

Basic Description

SynonymsFT-0734501 | NCGC00370724-05 | 1333377-65-3 | CHR6494 | CHR-6494 | HY-15217 | CS-0994 | BDBM50587785 | DTXSID90742629 | AKOS025149446 | F84874 | A899134 | 3-(1H-Indazol-5-yl)-N-propylimidazo-[1,2-b]pyridazin-6-amine | 3-(1H-indazol-5-yl)-N-propylimidazo[1
Specifications & Purity≥98%
Biochemical and Physiological MechanismsCHR-6494 is a potent and selective Haspin (Haploid Germ Cell-Specific Nuclear Protein Kinase) inhibitor that blocks H3T3ph phosphorylation. CHR-6494 causes cell cycle arrest in G2/M and subsequent apoptosis. CHR-6494 causes an abnormal duplication of cent
Storage TempStore at -20°C
Shipped InIce chest + Ice pads

Associated Targets(Human)

ABL1 Tclin Tyrosine-protein kinase ABL (18331 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GSK3B Tclin Glycogen synthase kinase-3 beta (11785 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PIM1 Tchem Serine/threonine-protein kinase PIM1 (9629 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
JAK3 Tclin Tyrosine-protein kinase JAK3 (8349 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CSNK1E Tclin Casein kinase I epsilon (1412 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HASPIN Tchem Serine/threonine-protein kinase haspin (906 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CDK5 Tchem Cyclin-dependent kinase 5/CDK5 activator 1 (3697 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CCNT1 Tchem CDK9/cyclin T1 (2643 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Dyrk1a Dual specificity tyrosine-phosphorylation-regulated kinase 1A (1629 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Clk1 Dual specificity protein kinase CLK1 (404 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name 3-(1H-indazol-5-yl)-N-propylimidazo[1,2-b]pyridazin-6-amine
INCHI InChI=1S/C16H16N6/c1-2-7-17-15-5-6-16-18-10-14(22(16)21-15)11-3-4-13-12(8-11)9-19-20-13/h3-6,8-10H,2,7H2,1H3,(H,17,21)(H,19,20)
InChi Key CZZCAOGIEGXMBZ-UHFFFAOYSA-N
Canonical SMILES CCCNC1=NN2C(=NC=C2C3=CC4=C(C=C3)NN=C4)C=C1
Isomeric SMILES CCCNC1=NN2C(=NC=C2C3=CC4=C(C=C3)NN=C4)C=C1
Alternate CAS 1458630-17-5 (TFA salt)
PubChem CID 70679308
Molecular Weight 292.34

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

SolubilityDMSO

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Solution Calculators