Chroman 1 - 99%, high purity , CAS No.1273579-40-0

Item Number

C646731

Grouped product items
SKU	Size	Availability	Price
C646731-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$59.90
C646731-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$210.90
C646731-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$340.90
C646731-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$499.90
C646731-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$980.90

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Basic Description

Synonyms	ROCK-II inhibitor \| (3S)-N-[2-[2-(dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-6-methoxy-3,4-dihydro-2H-chromene-3-carboxamide
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Chroman 1 is a highly potent and selective ROCK inhibitor. Chroman 1 is more potent against ROCK2 ( IC 50 =1 pM) than ROCK1 ( IC 50 =52 pM). Chroman 1 also has inhibitory activity against MRCK , with an IC 50 of 150 nM.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	Chroman 1 is a highly potent and selective ROCK inhibitor. Chroman 1 is more potent against ROCK2 ( IC 50 =1 pM) than ROCK1 ( IC 50 =52 pM). Chroman 1 also has inhibitory activity against MRCK , with an IC 50 of 150 nM In Vitro Chroman 1 (50 nM, 24 h) inhibits caspase-3/7 activation and reduces apoptosis in human pluripotent stem cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Apoptosis AnalysisCell Line: hESCs (human pluripotent stem cells) (WA09) Concentration: 50 nM Incubation Time: 0-12 h or 24 h Result: Reduced the number of apoptotic cells, reduced caspase-3/7 activation. Western Blot AnalysisCell Line: hESCs (human pluripotent stem cells) (WA09) Concentration: 50 nM Incubation Time: 24 h Result: Partially inhibited caspase-3 activation. Form:Solid IC50& Target:ROCK2\|1 pM (IC\|50\|)\|ROCK1\|52 pM (IC\|50\|)\|MRCK\|150 nM (IC\|50\|)

Canonical SMILES

CN(C)CCOC1=C(C=CC(=C1)C2=CNN=C2)NC(=O)[C@H]3CC4=C(C=CC(=C4)OC)OC3

Isomeric SMILES

CN(C)CCOC1=C(C=CC(=C1)C2=CNN=C2)NC(=O)[C@H]3CC4=C(C=CC(=C4)OC)OC3

PubChem CID

Molecular Weight

436.50

Certificates

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5 results found

Lot Number	Certificate Type	Date	Item
D2412143	Certificate of Analysis	Apr 01, 2024	C646731
D2412144	Certificate of Analysis	Apr 01, 2024	C646731
D2412145	Certificate of Analysis	Apr 01, 2024	C646731
D2412146	Certificate of Analysis	Apr 01, 2024	C646731
D2412147	Certificate of Analysis	Apr 01, 2024	C646731

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Basic Description