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Chromanol 293B - ≥99%(HPLC), high purity , CAS No.163163-23-3, Channel blocker of K v7.1

Item Number
C288018
Grouped product items
SKUSizeAvailabilityPrice Qty
C288018-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$424.90
C288018-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,912.90
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IKsblocker. Also blocks ICFTR

View related series
Kv7.1 Channel blocker

Basic Description

SynonymsChromanol 293B | 163163-23-3 | (-)-[3R,4S]-Chromanol 293B | 293B Cpd | (-)-Chromanol 293B | (3R,4S)-293B | LS-185874 | 163163-24-4 | 6-cyano-4-(N-ethylsulfonyl-N-methylamino)-3-hydroxy-2,2-dimethylchromane | CHEMBL434045 | CHEBI:34637 | chromanol 239B | Ethanesulfonamide, N-[(3R
Specifications & PurityMoligand™, ≥99%(HPLC)
Biochemical and Physiological MechanismsBlocker of the slow delayed rectifier K+current (IKs) (IC50= 1-10μM). Also blocks the CFTR chloride current (ICFTR) (IC50= 19μM).Enantiomeralso available.
Storage TempRoom temperature
Shipped InNormal
GradeMoligand™
Action TypeCHANNEL BLOCKER
Mechanism of actionChannel blocker of K v7.1

Associated Targets(Human)

KCNQ1 Tclin Potassium voltage-gated channel subfamily KQT member 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
KCNQ1 Tclin Voltage-gated potassium channel, IKs; KCNQ1(Kv7.1)/KCNE1(MinK) (185 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

KCNQ1 Voltage-gated potassium channel subunit Kv7.1 (54 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name N-[(3R,4S)-6-cyano-3-hydroxy-2,2-dimethyl-3,4-dihydrochromen-4-yl]-N-methylethanesulfonamide
INCHI InChI=1S/C15H20N2O4S/c1-5-22(19,20)17(4)13-11-8-10(9-16)6-7-12(11)21-15(2,3)14(13)18/h6-8,13-14,18H,5H2,1-4H3/t13-,14+/m0/s1
InChi Key HVSJHHXUORMCGK-UONOGXRCSA-N
Canonical SMILES CCS(=O)(=O)N(C)C1C(C(OC2=C1C=C(C=C2)C#N)(C)C)O
Isomeric SMILES CCS(=O)(=O)N(C)[C@@H]1[C@H](C(OC2=C1C=C(C=C2)C#N)(C)C)O
WGK Germany 3
PubChem CID 121846
Molecular Weight 324.39

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

SolubilitySolvent:ethanol, Max Conc. mg/mL: 6.49, Max Conc. mM: 20; Solvent:DMSO, Max Conc. mg/mL: 32.44, Max Conc. mM: 100

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H302:Harmful if swallowed

H312:Harmful in contact with skin

H332:Harmful if inhaled

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P270:Do not eat, drink or smoke when using this product.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P362+P364:Take off contaminated clothing and wash it before reuse.

P330:Rinse mouth.

P301+P317:IF SWALLOWED: Get medical help.

P317:Get emergency medical help.

WGK Germany 3
RIDADR NONHforallmodesoftransport

Related Documents

 SDS

 Specification Sheet

References

1. Seebohm G, Lerche C, Pusch M, Steinmeyer K, Brüggemann A, Busch AE.  (2001)  A kinetic study on the stereospecific inhibition of KCNQ1 and I(Ks) by the chromanol 293B..  Br J Pharmacol,  134  (8): (1647-54).  [PMID:11739240]

Solution Calculators

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