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Chromanol 293B - ≥99%(HPLC), high purity , CAS No.163163-23-3, Channel blocker of K v7.1

Item Number
C288018
Grouped product items
SKUSizeAvailabilityPrice Qty
C288018-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$424.90
C288018-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,912.90
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IKsblocker. Also blocks ICFTR

View related series
Kv7.1 Channel blocker Membrane Transporter/Ion Channel Potassium Channel

Basic Description

SynonymsCHEBI:34637 | (3R,4S)-Ethanesulfonic acid (6-cyano-3-hydroxy-2,2-dimethyl-chroman-4-yl)-methyl-amide | N-((3R,4S)-6-Cyano-3-hydroxy-2,2-dimethylchroman-4-yl)-N-methylethanesulfonamide | N-[(3R,4S)-6-cyano-3-hydroxy-2,2-dimethyl-3,4-dihydrochromen-4-yl]-N-
Specifications & PurityMoligand™, ≥99%(HPLC)
Biochemical and Physiological MechanismsBlocker of the slow delayed rectifier K+current (IKs) (IC50= 1-10μM). Also blocks the CFTR chloride current (ICFTR) (IC50= 19μM).Enantiomeralso available.
Storage TempRoom temperature
Shipped InNormal
GradeMoligand™
Action TypeCHANNEL BLOCKER
Mechanism of actionChannel blocker of K v7.1

Associated Targets(Human)

KCNQ1 Tclin Potassium voltage-gated channel subfamily KQT member 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
KCNQ1 Tclin Voltage-gated potassium channel, IKs; KCNQ1(Kv7.1)/KCNE1(MinK) (185 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

KCNQ1 Voltage-gated potassium channel subunit Kv7.1 (54 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name N-[(3R,4S)-6-cyano-3-hydroxy-2,2-dimethyl-3,4-dihydrochromen-4-yl]-N-methylethanesulfonamide
INCHI InChI=1S/C15H20N2O4S/c1-5-22(19,20)17(4)13-11-8-10(9-16)6-7-12(11)21-15(2,3)14(13)18/h6-8,13-14,18H,5H2,1-4H3/t13-,14+/m0/s1
InChi Key HVSJHHXUORMCGK-UONOGXRCSA-N
Canonical SMILES CCS(=O)(=O)N(C)C1C(C(OC2=C1C=C(C=C2)C#N)(C)C)O
Isomeric SMILES CCS(=O)(=O)N(C)[C@@H]1[C@H](C(OC2=C1C=C(C=C2)C#N)(C)C)O
WGK Germany 3
PubChem CID 121846
Molecular Weight 324.39

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

SolubilitySolvent:ethanol, Max Conc. mg/mL: 6.49, Max Conc. mM: 20; Solvent:DMSO, Max Conc. mg/mL: 32.44, Max Conc. mM: 100

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H302:Harmful if swallowed

H312:Harmful in contact with skin

H332:Harmful if inhaled

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P270:Do not eat, drink or smoke when using this product.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P362+P364:Take off contaminated clothing and wash it before reuse.

P330:Rinse mouth.

P301+P317:IF SWALLOWED: Get medical help.

P317:Get emergency medical help.

WGK Germany 3
RIDADR NONHforallmodesoftransport

Related Documents

 SDS

 Specification Sheet

References

1. Seebohm G, Lerche C, Pusch M, Steinmeyer K, Brüggemann A, Busch AE.  (2001)  A kinetic study on the stereospecific inhibition of KCNQ1 and I(Ks) by the chromanol 293B..  Br J Pharmacol,  134  (8): (1647-54).  [PMID:11739240] [10.1021/op500134e]

Solution Calculators

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