Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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C110078-20mg | 20mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $31.90 | |
C110078-100mg | 100mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $68.90 |
Synonyms | Chrysin, 97% | cid_5281607 | NCGC00168807-02 | 57D | HMS501O16 | KBioSS_000725 | Chrysin,(S) | LMPK12110189 | NCGC00016456-09 | SDCCGMLS-0066586.P001 | SPECTRUM1505144 | Spectrum3_001399 | CCG-40148 | NCGC00016456-07 | NINDS_000614 | 5,7-Dihydroxyflavone |
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Specifications & Purity | Moligand™, analytical standard, ≥98% |
Shipped In | Normal |
Grade | analytical standard, Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Inhibitor of CYP1A1;Inhibitor of CYP1B1 |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 5,7-dihydroxy-2-phenylchromen-4-one |
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INCHI | InChI=1S/C15H10O4/c16-10-6-11(17)15-12(18)8-13(19-14(15)7-10)9-4-2-1-3-5-9/h1-8,16-17H |
InChi Key | RTIXKCRFFJGDFG-UHFFFAOYSA-N |
Canonical SMILES | C1=CC=C(C=C1)C2=CC(=O)C3=C(C=C(C=C3O2)O)O |
Isomeric SMILES | C1=CC=C(C=C1)C2=CC(=O)C3=C(C=C(C=C3O2)O)O |
PubChem CID | 5281607 |
Molecular Weight | 254.24 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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E2423202 | Certificate of Analysis | May 29, 2024 | C110078 |
H2202134 | Certificate of Analysis | Jul 20, 2023 | C110078 |
H2204391 | Certificate of Analysis | Jul 20, 2023 | C110078 |
I2118048 | Certificate of Analysis | Jun 15, 2023 | C110078 |
I1521027 | Certificate of Analysis | Mar 09, 2023 | C110078 |
F1812032 | Certificate of Analysis | Feb 18, 2022 | C110078 |
Melt Point(°C) | 285-286°C |
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Merck Index | 2256 |
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1. Lei Liu, Yingyu Sima, Jinxia Feng, Shuting Shi, Aiting Chen, Chuanqin Zhou, Quanguo He, Yimin Tan. (2024) Bismuth oxide and nitrogen-doped reduced graphene oxide co-modified glassy carbon electrode to perform sensitive electrochemical sensing and determination of chrysin in pharmaceutical capsules. MICROCHEMICAL JOURNAL, 196 (109544). [PMID:1341900] [10.1016/j.microc.2023.109544] |
2. Shuang Xiao, Peng Zhang, Guowen Zhang, Wenwen Li, Haowen Lin, Xing Hu. (2023) Inhibition of toll-like receptor 4 activation by apigenin and chrysin via competition for sites and conformational changes. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 252 (126415). [PMID:37598817] [10.1016/j.ijbiomac.2023.126415] |
3. Xinyan Tao, Yuan Liu, Zhenhua Ding, Shuang Xie, Wenxiong Cao, Xiaohong Li. (2023) Injectable cell-targeting fiber rods to promote lipolysis and regulate inflammation for obesity treatment. Biomaterials Science, [PMID:37432672] [10.1039/D3BM00619K] |
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6. Ruiyi Fan, Congyi Zhu, Diyang Qiu, Genlin Mao, Bernd Mueller-Roeber, Jiwu Zeng. (2023) Integrated transcriptomic and metabolomic analyses reveal key genes controlling flavonoid biosynthesis in Citrus grandis ‘Tomentosa’ fruits. PLANT PHYSIOLOGY AND BIOCHEMISTRY, 196 (210). [PMID:36724705] [10.1016/j.plaphy.2023.01.050] |
7. Chun Xiao Li, Fu Rong Wang, Bing Zhang, Ze Yuan Deng, Hong Yan Li. (2023) Stability and antioxidant activity of phenolic compounds during in vitro digestion. JOURNAL OF FOOD SCIENCE, 88 (2): (696-716). [PMID:36617678] [10.1111/1750-3841.16440] |
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12. Lingli Zhao, Mengfei Zheng, Hao Cai, Juan Chen, Yan Lin, Fangbin Wang, Lu Wang, Xian Zhang, Jian Liu. (2023) The activity comparison of six dietary flavonoids identifies that luteolin inhibits 3T3-L1 adipocyte differentiation through reducing ROS generation. JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 112 (109208). [PMID:36370929] [10.1016/j.jnutbio.2022.109208] |
13. Jie Zhao, Lin Huang, Renjie Li, Zhuangwei Zhang, Jin Chen, Hongjin Tang. (2022) Insights from multi-spectroscopic analysis and molecular modeling to understand the structure–affinity relationship and the interaction mechanism of flavonoids with gliadin. Food & Function, 13 (9): (5061-5074). [PMID:35404372] [10.1039/D1FO03816H] |
14. Zuoxing Wu, Chen Li, Yu Chen, Qian Liu, Na Li, Xuemei He, Weibin Li, Rong Shen, Li Li, Chenming Wei, Siyuan Shao, Fangsheng Fu, Jiaxin Ding, Xiaochen Sun, Dairong Wang, Guixin Yuan, Yiji Su, Jinmin Zhao, Jiake Xu, Ren Xu, Xin Xu, Feng Xu. (2022) Chrysin Protects Against Titanium Particle-Induced Osteolysis by Attenuating Osteoclast Formation and Function by Inhibiting NF-κB and MAPK Signaling. Frontiers in Pharmacology, 13 (793087). [PMID:35401243] [10.3389/fphar.2022.793087] |
15. Jie Zhao, Lin Huang, Renjie Li, Zhuangwei Zhang, Jin Chen, Hongjin Tang. (2022) Multispectroscopic and computational evaluation of the binding of flavonoids with bovine serum albumin in the presence of Cu2+. FOOD CHEMISTRY, 385 (132656). [PMID:35279499] [10.1016/j.foodchem.2022.132656] |
16. Hongjin Tang, Lin Huang, Dongsheng Zhao, Chunyong Sun, Ping Song. (2020) Interaction mechanism of flavonoids on bovine serum albumin: Insights from molecular property-binding affinity relationship. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 239 (118519). [PMID:32480277] [10.1016/j.saa.2020.118519] |
17. Jie Zhao, Lin Huang, Chunyong Sun, Dongsheng Zhao, Hongjin Tang. (2020) Studies on the structure-activity relationship and interaction mechanism of flavonoids and xanthine oxidase through enzyme kinetics, spectroscopy methods and molecular simulations. FOOD CHEMISTRY, 323 (126807). [PMID:32330646] [10.1016/j.foodchem.2020.126807] |
18. Ding Liu, Qizhi Zhang, Lang Zhang, Wenmei Yu, Huizhi Long, Jun He, Yunmei Liu. (2020) Novel photosensitizing properties of porphyrin–chrysin derivatives with antitumor activity in vitro. JOURNAL OF CHEMICAL RESEARCH, [PMID:] [10.1177/1747519820907248] |
19. Su Liqiang, Li Jijiao, Han Shuang. (2019) Controllable Preparation and Application of Quercetin Molecularly Imprinted Polymer. RUSSIAN JOURNAL OF APPLIED CHEMISTRY, 92 (7): (972-981). [PMID:] [10.1134/S1070427219070140] |
20. Chengyun He, Xiaoling Liu, Zhaojing Jiang, Sheng Geng, Hanjun Ma, Benguo Liu. (2019) Interaction Mechanism of Flavonoids and α-Glucosidase: Experimental and Molecular Modelling Studies. Foods, 8 (9): (355). [PMID:31438605] [10.3390/foods8090355] |
21. Yao Yu, Cheng Xu, Le Zhen, Shan Yang, Jianping Zhou, Jing Yao. (2019) Bio-inspired drug-dominated supramolecular nanocomplex based on low molecular weight heparin for progressive tumor therapy. CARBOHYDRATE POLYMERS, 220 (30). [PMID:31196548] [10.1016/j.carbpol.2019.05.051] |
22. Qian Liu, Hai-Long Wu, Zhi Liu, Rong Xiao, Tong Wang, Yong Hu, Yu-Jie Ding, Ru-Qin Yu. (2018) Chemometrics-assisted HPLC-DAD as a rapid and interference-free strategy for simultaneous determination of 17 polyphenols in raw propolis. Analytical Methods, 10 (46): (5577-5588). [PMID:] [10.1039/C8AY01986J] |
23. Shishi Li, Jinjin Xu, Zhihong Yao, Liufang Hu, Zifei Qin, Hao Gao, Kristopher W. Krausz, Frank J. Gonzalez, Xinsheng Yao. (2018) The roles of breast cancer resistance protein (BCRP/ABCG2) and multidrug resistance-associated proteins (MRPs/ABCCs) in the excretion of cycloicaritin-3-O-glucoronide in UGT1A1-overexpressing HeLa cells. CHEMICO-BIOLOGICAL INTERACTIONS, 296 (45). [PMID:30237061] [10.1016/j.cbi.2018.09.001] |
24. Yang Mei, Xiong Jun, Zou Qiang, Wang Dan-Dan, Huang Cong-Xin. (2018) Chrysin attenuates interstitial fibrosis and improves cardiac function in a rat model of acute myocardial infarction. JOURNAL OF MOLECULAR HISTOLOGY, 49 (6): (555-565). [PMID:30225683] [10.1007/s10735-018-9793-0] |
25. Hui Wang, Wenxi Zhang, Yatao Cheng, Xinyu Zhang, Nannan Xue, Gaorong Wu, Meng Chen, Kang Fang, Wenbo Guo, Fei Zhou, Herong Cui, Tao Ma, Penglong Wang, Haimin Lei. (2018) Design, Synthesis and Biological Evaluation of Ligustrazine-Flavonoid Derivatives as Potential Anti-Tumor Agents. MOLECULES, 23 (9): (2187). [PMID:30200208] [10.3390/molecules23092187] |
26. Ding Liu, Yan-peng Li, Hong-xiu Shen, Yang Li, Jun He, Qi-zhi Zhang, Yun-mei Liu. (2018) Synthesis and anti-tumor activities of novel 7-O-amino acids chrysin derivatives. Chinese Herbal Medicines, 10 (323). [PMID:] [10.1016/j.chmed.2018.07.002] |
27. Qing-Hui Wen, Lang-Hong Wang, Xin-An Zeng, De-Bao Niu, Man-Sheng Wang. (2018) Hydroxyl-related differences for three dietary flavonoids as inhibitors of human purine nucleoside phosphorylase. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 118 (588). [PMID:29894785] [10.1016/j.ijbiomac.2018.06.045] |
28. Han Peng, Zeyuan Deng, Xuan Chen, Yong Sun, Bing Zhang, Hongyan Li. (2018) Major chemical constituents and antioxidant activities of different extracts from the peduncles of Hovenia acerba Lindl. INTERNATIONAL JOURNAL OF FOOD PROPERTIES, [PMID:] [10.1080/10942912.2018.1497059] |
29. Geyuan Li, Kai Zhang, Meriem Fizir, Muchuan Niu, Cheng Sun, Shuangling Xi, Xuanhong Hui, Jianrong Shi, Hua He. (2017) Rational design, preparation and adsorption study of a magnetic molecularly imprinted polymer using a dummy template and a bifunctional monomer. NEW JOURNAL OF CHEMISTRY, 41 (15): (7092-7101). [PMID:] [10.1039/C7NJ00689F] |
30. Zhengkun Xie, Gaiping Li, Yamin Fu, Mengjiao Sun, Baoxian Ye. (2017) Sensitive, simultaneous determination of chrysin and baicalein based on Ta2O5-chitosan composite modified carbon paste electrode. TALANTA, 165 (553). [PMID:28153298] [10.1016/j.talanta.2017.01.021] |
31. Dong Dong, Enxi Quan, Xue Yuan, Qian Xie, Zhijie Li, Baojian Wu. (2017) Sodium Oleate-Based Nanoemulsion Enhances Oral Absorption of Chrysin through Inhibition of UGT-Mediated Metabolism. MOLECULAR PHARMACEUTICS, 14 (9): (2864–2874). [PMID:27983856] [10.1021/acs.molpharmaceut.6b00851] |
32. Shuzhen Yang, Jie Zhou, Dongmei Li, Chunyu Shang, Litao Peng, Siyi Pan. (2017) The structure-antifungal activity relationship of 5,7-dihydroxyflavonoids against Penicillium italicum. FOOD CHEMISTRY, 224 (26). [PMID:28159264] [10.1016/j.foodchem.2016.12.001] |
33. Zhengkun Xie, Yongmei Wu, Sheng Kai, Gaiping Li, Baoxian Ye. (2016) A Newly Competitive Electrochemical Sensor for Sensitive Determination of Chrysin Based on Electrochemically Activated Ta2O5 Particles Modified Carbon Paste Electrode. ELECTROANALYSIS, 29 (3): (835-842). [PMID:] [10.1002/elan.201600442] |
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