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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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C126432-10mg | 10mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $53.90 | |
C126432-50mg | 50mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $81.90 | |
C126432-250mg | 250mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $369.90 |
Potent, selective HDAC inhibitor. Cell-permeable.
Synonyms | Tacedinaline | 112522-64-2 | ci-994 | 4-acetamido-N-(2-aminophenyl)benzamide | Acetyldinaline | CI 994 | 4-acetylamino-N-(2'-aminophenyl)benzamide | CI994 (Tacedinaline) | Tacedinalina | N-acetyldinaline | Goe 5549 | Goe-5549 | PD-123654 | PD 123654 | 4-(Acetylamino)-N-(2-aminopheny |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Description: IC50 Value: 0.57 uM (For HDAC1,MTT assay) CI-994 (N-acetyldinaline) is a novel oral compound with a wide spectrum of antitumor activity in preclinical models, in vitro and in vivo. The mechanism of action may involve inhibition of histone dea |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Histone deacetylase inhibitor |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | CI-994 (Tacedinaline) is an anti-cancer drug which inhibits HDAC1 with IC50 of 0.57 μM and causes G1 cell cycle arrest. |
ALogP | 1.3 |
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IUPAC Name | 4-acetamido-N-(2-aminophenyl)benzamide |
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INCHI | InChI=1S/C15H15N3O2/c1-10(19)17-12-8-6-11(7-9-12)15(20)18-14-5-3-2-4-13(14)16/h2-9H,16H2,1H3,(H,17,19)(H,18,20) |
InChi Key | VAZAPHZUAVEOMC-UHFFFAOYSA-N |
Canonical SMILES | CC(=O)NC1=CC=C(C=C1)C(=O)NC2=CC=CC=C2N |
Isomeric SMILES | CC(=O)NC1=CC=C(C=C1)C(=O)NC2=CC=CC=C2N |
WGK Germany | 3 |
RTECS | CU8702023 |
PubChem CID | 2746 |
Molecular Weight | 269.3 |
PubChem CID | 2746 |
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CAS Registry No. | 112522-64-2 |
ChEMBL Ligand | CHEMBL235191 |
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Solubility | DMSO 54 mg/mL Water <1 mg/mL Ethanol <1 mg/mL |
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Sensitivity | Heat Sensitive |
Melt Point(°C) | 242 °C(dec.) |
Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H319:Causes serious eye irritation |
Precautionary Statements | P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. |
WGK Germany | 3 |
RTECS | CU8702023 |
1. Loprevite M, Tiseo M, Grossi F, Scolaro T, Semino C, Pandolfi A, Favoni R, Ardizzoni A. (2005) In vitro study of CI-994, a histone deacetylase inhibitor, in non-small cell lung cancer cell lines.. Oncol Res, 15 (1): (39-48). [PMID:15839304] |
2. Gediya LK, Belosay A, Khandelwal A, Purushottamachar P, Njar VC. (2008) Improved synthesis of histone deacetylase inhibitors (HDIs) (MS-275 and CI-994) and inhibitory effects of HDIs alone or in combination with RAMBAs or retinoids on growth of human LNCaP prostate cancer cells and tumor xenografts.. Bioorg Med Chem, 16 (6): (3352-60). [PMID:18166465] |
3. Methot JL, Chakravarty PK, Chenard M, Close J, Cruz JC, Dahlberg WK, Fleming J, Hamblett CL, Hamill JE, Harrington P et al.. (2008) Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2).. Bioorg Med Chem Lett, 18 (3): (973-8). [PMID:18182289] |
4. Liu L, Chen B, Qin S, Li S, He X, Qiu S, Zhao W, Zhao H. (2010) A novel histone deacetylase inhibitor Chidamide induces apoptosis of human colon cancer cells.. Biochem Biophys Res Commun, 392 (2): (190-5). [PMID:20060381] |
5. LoRusso PM, Demchik L, Foster B, Knight J, Bissery MC, Polin LM, Leopold 3rd WR, Corbett TH. (1996) Preclinical antitumor activity of CI-994.. Invest New Drugs, 14 (4): (349-56). [PMID:9157069] |