Potent and selective inhibitor of integrinsαvβ3andαvβ5(IC50values are 4.1 and 70 nM, respectively). Exhibits ~10-fold selectivity over gpIIb/IIIa. Increases endothelial monolayer permeability. Also exhibits antiangiogenic activity.
Storage Temp
Store at -80°C
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Product Description
Cilengitide is a potent integrin inhibitor for αvβ3 receptor and αvβ5 receptor with IC50 of 4.1 nM and 79 nM, respectively; ~10-fold selectivity against gpIIbIIIa.
1.Ying Song, Chen Li, Yahan Fu, Qiu Xie, Jun Guo, Guangming Li, Huiwen Wu. (2020) Inward Tension of Talin and Integrin-related Osmotic Pressure are involved Synergetically in the Invasion and Metastasis of Non-small Cell Lung Cancer. Journal of Cancer, 11 (17):( 5032–5041). [PMID:32742451]
2.Yifan Wang, Xiaolong Zhang, Jilai Tian, Jinjun Shan, Yunfeng Hu, Yiqian Zhai, Jun Guo. (2019) Talin promotes integrin activation accompanied by generation of tension in talin and an increase in osmotic pressure in neurite outgrowth. FASEB JOURNAL, 33 (5):(6311-6326). [PMID:30768370]
3.Siming Yu, Linna Li, Wei Tian, Dan Nie, Wei Mu, Fang Qiu, Yu Liu, Xinghan Liu, Xiaofeng Wang, Zhimin Du, Wen-Feng Chu, Baofeng Yang. (2018) PEP06 polypeptide 30 exerts antitumour effect in colorectal carcinoma via inhibiting epithelial–mesenchymal transition. BRITISH JOURNAL OF PHARMACOLOGY, 175 (15):(3111-3130). [PMID:29722931]
References
1.Ying Song, Chen Li, Yahan Fu, Qiu Xie, Jun Guo, Guangming Li, Huiwen Wu. (2020) Inward Tension of Talin and Integrin-related Osmotic Pressure are involved Synergetically in the Invasion and Metastasis of Non-small Cell Lung Cancer. Journal of Cancer, 11 (17):( 5032–5041). [PMID:32742451]
2.Yifan Wang, Xiaolong Zhang, Jilai Tian, Jinjun Shan, Yunfeng Hu, Yiqian Zhai, Jun Guo. (2019) Talin promotes integrin activation accompanied by generation of tension in talin and an increase in osmotic pressure in neurite outgrowth. FASEB JOURNAL, 33 (5):(6311-6326). [PMID:30768370]
3.Siming Yu, Linna Li, Wei Tian, Dan Nie, Wei Mu, Fang Qiu, Yu Liu, Xinghan Liu, Xiaofeng Wang, Zhimin Du, Wen-Feng Chu, Baofeng Yang. (2018) PEP06 polypeptide 30 exerts antitumour effect in colorectal carcinoma via inhibiting epithelial–mesenchymal transition. BRITISH JOURNAL OF PHARMACOLOGY, 175 (15):(3111-3130). [PMID:29722931]
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