Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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C274669-10mg | 10mg | In stock | $118.90 | |
C274669-50mg | 50mg | In stock | $445.90 | |
C274669-100mg | 100mg | In stock | $793.90 | |
C274669-250mg | 250mg | In stock | $1,786.90 |
Potent, selective PDE3 inhibitor
Synonyms | BRD-K28578425-001-06-2 | EU-0100288 | Cilostamide - CAS 68550-75-4 | NCGC00015269-02 | NCGC00015269-05 | SR-01000075781 | Cilostamida [INN-Spanish] | OPC 3689 | Tox21_110119 | SR-01000075781-1 | Cilostamida | 45S5605Q18 | NCGC00015269-11 | MFCD00673958 | |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Potent, selective PDE3 inhibitor (IC 50 values are 27 and 50 nM for PDE3A and PDE3B, respectively). Inhibits ADP-induced platelet aggregation (IC 50 = 16.8 μM). Antithrombotic effects in vivo. Orally active. |
Storage Temp | Store at -20°C,Argon charged |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Inhibitor of phosphodiesterase 3A;Inhibitor of phosphodiesterase 3B |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Store at Room Temperature. The product can be stored for up to 12 months. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Pubchem Sid | 488179720 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488179720 |
IUPAC Name | N-cyclohexyl-N-methyl-4-[(2-oxo-1H-quinolin-6-yl)oxy]butanamide |
INCHI | InChI=1S/C20H26N2O3/c1-22(16-6-3-2-4-7-16)20(24)8-5-13-25-17-10-11-18-15(14-17)9-12-19(23)21-18/h9-12,14,16H,2-8,13H2,1H3,(H,21,23) |
InChi Key | UIAYVIIHMORPSJ-UHFFFAOYSA-N |
Canonical SMILES | CN(C1CCCCC1)C(=O)CCCOC2=CC3=C(C=C2)NC(=O)C=C3 |
Isomeric SMILES | CN(C1CCCCC1)C(=O)CCCOC2=CC3=C(C=C2)NC(=O)C=C3 |
PubChem CID | 2753 |
Molecular Weight | 342.4 |
CAS Registry No. | 68550-75-4 |
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ChEMBL Ligand | CHEMBL34431 |
PubChem CID | 2753 |
Wikipedia | Cilostamide |
PubChem SID | 488179720 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
F23281142 | Certificate of Analysis | May 09, 2024 | C274669 |
F23281138 | Certificate of Analysis | May 09, 2024 | C274669 |
F23281140 | Certificate of Analysis | Apr 11, 2024 | C274669 |
F23281139 | Certificate of Analysis | Apr 11, 2024 | C274669 |
F23281014 | Certificate of Analysis | Apr 03, 2024 | C274669 |
F23281053 | Certificate of Analysis | Apr 03, 2024 | C274669 |
F23281136 | Certificate of Analysis | Apr 03, 2024 | C274669 |
F23281137 | Certificate of Analysis | Apr 03, 2024 | C274669 |
Solubility | Soluble in DMSO to 100 mM |
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Starting at $241.90
1. Jönsson C et al.. (2019) Insulin and ß-adrenergic receptors mediate lipolytic and anti-lipolytic signalling that is not altered by type 2 diabetes in human adipocytes.. Biochem J, 476 (19): (2883-2908). [PMID:31519735] |