Cilostazol - ≥99%, high purity , Phosphodiesterase 3A inhibitor, CAS No.73963-72-1, Phosphodiesterase 3A inhibitor

Item Number

C129678

• Synonyms: 6-(4-(1-Cyclohexyl-1H-tetrazol-5-yl)butoxy)-3,4-dihydro-2(1H)-quinolinone | CILOSTAZOL [MART.] | REGID_for_CID_2754 | MLS001076067 | SPECTRUM1505230 | Cilostazol (USAN:USP:INN:BAN:JAN) | 2(1H)-Quinolinone, 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-d
• Specifications & Purity: Moligand™, ≥99%
• Biochemical and Physiological Mechanisms: Potent and selective PDE3A inhibitor (IC 50 = 200 nM). Inhibits adenosine uptake. Prevents elevation of intracellular cAMP levels. Inhibits ovulation. S hows neuroprotective, vasodilatory and antithrombotic effects in vivo. Orally active.
• Storage Temp: Store at 2-8°C
• Shipped In: Wet ice
• Grade: Moligand™
• Action Type: INHIBITOR
• Mechanism of action: Phosphodiesterase 3A inhibitor
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

Cilastazol is a 2-oxo-quinoline with vasodilator, antimitogenic, antithrombotic, and cardiotonic properties. This compound has been shown to cause inhibition of adenosine uptake, eventually resulting in changes to cAMP levels. Studies have shown Cilostazol to be a potent inhibitor of PDE3A (phosphodiesterase 3A) in the cardiovascular system. In addition Cilastazol has also been observed to inhibit mitogenesis, migration of vascular smooth muscle cells, and platelet aggregation. Cilostazol displays a capacity to lower levels of serum triglycerides and cause some increase in HDL-cholesterol levels.
Phosphodiesterase III (PDE3) inhibitor, antimitogenic, antithrombotic, and cardiotonic agent.