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Cinchonidine - 98%, high purity , CAS No.485-71-2

4 Citations
  • ≥98%
Item Number
C109632
Grouped product items
SKUSizeAvailabilityPrice Qty
C109632-1g
1g
In stock
$9.90
C109632-5g
5g
In stock
$14.90
C109632-25g
25g
In stock
$56.90
C109632-100g
100g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$203.90
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Quinine analog. Lysosomotropic agent.

View related series
Anti-infection Neuronal Signaling Parasite Pyridines Serotonin Transporter Six-Membered Heterocyclic Compounds

Basic Description

SynonymsBRD-K17661460-001-04-0 | BRD-K39079086-001-05-0 | IDI1_000501 | AKOS016008633 | HY-N0173 | KBio2_006781 | KBioGR_001805 | PDSP2_000142 | (R)-quinolin-4-yl((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methanol | SDCCGMLS-0066969.P001 | Spectrum5_000964 | QUININE
Specifications & Purity≥98%
Biochemical and Physiological MechanismsQuinine analog. Lysosomotropic agent. Inhibits Plasmodium falciparum. Interferes with ferriprotoporphyrin formation. Weak SERT inhibitor. Shows antimalarial effects in vivo. Orally active.
Storage TempProtected from light
Shipped InNormal
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

application：

It finds its uses as an antimalarial compound. It is a lysosomotropic agent, inhibits Plasmodium falciparum, interferes with ferriprotoporphyrin formation and is a weak SERT inhibitor.

Associated Targets(Human)

ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC2A1 Tchem Glucose transporter (14755 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
WI-38 (2654 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HepG2 (196354 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
POLI Tchem DNA polymerase iota (116820 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

ampC Beta-lactamase AmpC (62480 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Trypanosoma brucei brucei (13300 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ht1 Hexose transporter 1 (14071 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BCHE Cholinesterase (8742 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Leishmania mexicana mexicana (27 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

Pubchem Sid488187274
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488187274
IUPAC Name (R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-quinolin-4-ylmethanol
INCHI InChI=1S/C19H22N2O/c1-2-13-12-21-10-8-14(13)11-18(21)19(22)16-7-9-20-17-6-4-3-5-15(16)17/h2-7,9,13-14,18-19,22H,1,8,10-12H2/t13-,14-,18-,19+/m0/s1
InChi Key KMPWYEUPVWOPIM-KODHJQJWSA-N
Canonical SMILES C=CC1CN2CCC1CC2C(C3=CC=NC4=CC=CC=C34)O
Isomeric SMILES C=C[C@H]1CN2CC[C@H]1C[C@H]2[C@@H](C3=CC=NC4=CC=CC=C34)O
WGK Germany 3
RTECS GD2975000
PubChem CID 101744
Molecular Weight 294.39
Beilstein 89690
Reaxy-Rn 5286475

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

10 results found

Lot NumberCertificate TypeDateItem
D2410264Certificate of AnalysisMar 20, 2024 C109632
C23211017Certificate of AnalysisJul 15, 2022 C109632
C2426022Certificate of AnalysisJul 15, 2022 C109632
D2423057Certificate of AnalysisJul 15, 2022 C109632
J2211779Certificate of AnalysisJul 15, 2022 C109632
J2211843Certificate of AnalysisJul 15, 2022 C109632
J2211859Certificate of AnalysisJul 15, 2022 C109632
J2211921Certificate of AnalysisJul 15, 2022 C109632
D1816118Certificate of AnalysisFeb 22, 2022 C109632
D1816119Certificate of AnalysisFeb 22, 2022 C109632

Chemical and Physical Properties

SolubilityInsoluble in water; Soluble in Alcohol,Ether,Chloroform
SensitivityLight Sensitive
Specific Rotation[α]-107.5 ° (C=1, EtOH)
Melt Point(°C)204-206°C

Safety and Hazards(GHS)

Pictogram(s) GHS08,   GHS07
Signal Warning
Hazard Statements

H373:Causes damage to organs through prolonged or repeated exposure

H302:Harmful if swallowed

H317:May cause an allergic skin reaction

H361:Suspected of damaging fertility or the unborn child

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P260:Do not breathe dust/fume/gas/mist/vapors/spray.

P270:Do not eat, drink or smoke when using this product.

P272:Contaminated work clothing should not be allowed out of the workplace.

P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention.

P362+P364:Take off contaminated clothing and wash it before reuse.

P330:Rinse mouth.

P203:Obtain, read and follow all safety instructions before use.

P301+P317:IF SWALLOWED: Get medical help.

P318:if exposed or concerned, get medical advice.

P319:Get medical help if you feel unwell.

WGK Germany 3
RTECS GD2975000
Reaxy-Rn 5286475
Merck Index 2286

Related Documents

 SDS

 Specification Sheet

Citations of This Product

How to Cite Aladdin Scientific Products?
1. Huan Xue, Hao-Jie Xing, Bin Wang, Chao Fu, Yu-Shan Zhang, Xi Qiao, Chao Guo, Xiao-Li Zhang, Bin Hu, Xin Zhao, Li-Jiao Deng, Xiao-Chan Zhu, Yi Zhang, Yun-Feng Liu.  (2023)  Cinchonine, a Potential Oral Small-Molecule Glucagon-Like Peptide-1 Receptor Agonist, Lowers Blood Glucose and Ameliorates Non-Alcoholic Steatohepatitis.  Drug Design Development and Therapy,      [PMID:37197367] [10.2147/DDDT.S404055]
2. Zhi-Yuan Zhang, Li-Li Rui, Ya-Li Lin, Hui-Dan Zhang, Ji-Ming Ou, Jian-Feng He, Quan-Zhou Wu.  (2021)  Preparation of ordered macroporous molecularly imprinted polymers and their applications in purifying cinchona alkaloids from cinchona extract.  POLYMER INTERNATIONAL,  70  (9): (1344-1355).  [PMID:] [10.1002/pi.6205]
3. Yuan Tan, Lijing Jing, Yonghong Ding, Tianxin Wei.  (2015)  A novel double-layer molecularly imprinted polymer film based surface plasmon resonance for determination of testosterone in aqueous media.  APPLIED SURFACE SCIENCE,  342  (84).  [PMID:] [10.1016/j.apsusc.2015.03.031]
4. Li Liu, Xuecai Tan, Xiaoxue Fang, Yuexin Sun, Fuhou Lei, Zaiyin Huang.  (2012)  Electrochemical Sensor Based on Molecularly Imprinted Polymer Film Prepared with Functional Abietic-Type Acids as Cross-Linker for the Determination of Quinine.  ELECTROANALYSIS,  24  (7): (1647-1654).  [PMID:] [10.1002/elan.201200085]

References

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22. Simon Diezi,Davide Ferri,Angelo Vargas,Tamas Mallat,Alfons Baiker.  (2006-03-23)  The origin of chemo- and enantioselectivity in the hydrogenation of diketones on platinum..  Journal of the American Chemical Society,  128  ((12)): (4048-4057).  [PMID:16551114]
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24. Kensuke Fukiya,Kunio Itoh,Satoshi Yamaguchi,Akiko Kishiba,Mayuko Adachi,Nobuaki Watanabe,Yorihisa Tanaka.  (2009-11-17)  A single amino acid substitution confers high cinchonidine oxidation activity comparable with that of rabbit to monkey aldehyde oxidase 1..  Drug metabolism and disposition: the biological fate of chemicals,  38  ((2)): (302-307).  [PMID:19910515]
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30. Huan Xue, Hao-Jie Xing, Bin Wang, Chao Fu, Yu-Shan Zhang, Xi Qiao, Chao Guo, Xiao-Li Zhang, Bin Hu, Xin Zhao, Li-Jiao Deng, Xiao-Chan Zhu, Yi Zhang, Yun-Feng Liu.  (2023)  Cinchonine, a Potential Oral Small-Molecule Glucagon-Like Peptide-1 Receptor Agonist, Lowers Blood Glucose and Ameliorates Non-Alcoholic Steatohepatitis.  Drug Design Development and Therapy,      [PMID:37197367] [10.2147/DDDT.S404055]
31. Zhi-Yuan Zhang, Li-Li Rui, Ya-Li Lin, Hui-Dan Zhang, Ji-Ming Ou, Jian-Feng He, Quan-Zhou Wu.  (2021)  Preparation of ordered macroporous molecularly imprinted polymers and their applications in purifying cinchona alkaloids from cinchona extract.  POLYMER INTERNATIONAL,  70  (9): (1344-1355).  [PMID:] [10.1002/pi.6205]
32. Yuan Tan, Lijing Jing, Yonghong Ding, Tianxin Wei.  (2015)  A novel double-layer molecularly imprinted polymer film based surface plasmon resonance for determination of testosterone in aqueous media.  APPLIED SURFACE SCIENCE,  342  (84).  [PMID:] [10.1016/j.apsusc.2015.03.031]
33. Li Liu, Xuecai Tan, Xiaoxue Fang, Yuexin Sun, Fuhou Lei, Zaiyin Huang.  (2012)  Electrochemical Sensor Based on Molecularly Imprinted Polymer Film Prepared with Functional Abietic-Type Acids as Cross-Linker for the Determination of Quinine.  ELECTROANALYSIS,  24  (7): (1647-1654).  [PMID:] [10.1002/elan.201200085]

Solution Calculators

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