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(+)-Cinchonine - 85%, high purity , CAS No.118-10-5

1 Citations

≥85%

CAS#: 118-10-5
Formula: C₁₉H₂₂N₂O
Molecular Weight: 294.39
Beilstein Registry Number: 89689
EC Number: 204-234-6
PubChem CID: 90454

Item Number

C431523

Grouped product items
SKU	Size	Availability	Price	Qty
C431523-25g	25g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$124.90
C431523-100g	100g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$347.90

Basic Description

Synonyms	cinchonine \| 118-10-5 \| (+)-Cinchonine \| D-Cinchonine \| Cinchonan-9-ol, (9S)- \| (8R,9S)-Cinchonine \| (9S)-Cinchonan-9-ol \| (+)-Cinconine \| TCMDC-123933 \| cinchonin \| (+)-cinchonin \| GNF-Pf-3189 \| NSC-6176 \| V43X79NZCD \| (1S)-Quinolin-4-yl((2R,4S,5R)-5-vinylquinuclidin-2-yl)methanol \|
Specifications & Purity	≥85%
Product Description	General Description (+)-Cinchonine, one of the alkaloids found in the barks of cinchona tree, is mainly used in the treatment of malaria. It belongs to the monoclinic crystal system and P 2 1 space group. The solubility of cinchonine can be improved by the formation of inclusion complexes with cyclodextrins. Application (+)-Cinchonine, in the presence of lithium diisopropylamide (LDA) forms a complex, which can catalyze the asymmetric conjugate addition of benzyl- and alkylphosphonates to aromatic and heteroaromatic nitroalkenes to form the corresponding adducts. Other Notes remainder dihydrocinchonine

Associated Targets(Human)

CYP2D6 Tclin Cytochrome P450 2D6 (0 Activities)

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GMNN Tbio Geminin (0 Activities)

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HDAC6 Tclin Histone deacetylase 6 (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ACHE Tclin Acetylcholinesterase (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BCHE Tclin Cholinesterase (0 Activities)

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SLC2A1 Tchem Solute carrier family 2, facilitated glucose transporter member 1 (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NFE2L2 Tchem Nuclear factor erythroid 2-related factor 2 (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ACHE Tclin Acetylcholinesterase (18204 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLC2A1 Tchem Glucose transporter (14755 Activities)

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CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)

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A498 (42825 Activities)

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ACHN (49357 Activities)

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CAKI-1 (44928 Activities)

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COLO 205 (50209 Activities)

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DU-145 (51482 Activities)

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HL-60 (67320 Activities)

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HT-29 (80576 Activities)

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Huh-7 (12904 Activities)

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K562 (73714 Activities)

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KM12 (47707 Activities)

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M14 (47487 Activities)

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MCF7 (126967 Activities)

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MOLT-4 (49676 Activities)

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OVCAR-3 (48710 Activities)

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OVCAR-4 (44535 Activities)

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OVCAR-5 (45555 Activities)

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OVCAR-8 (47708 Activities)

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PC-3 (62116 Activities)

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RPMI-8226 (44974 Activities)

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RXF 393 (41971 Activities)

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SF-295 (48000 Activities)

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SK-MEL-2 (46422 Activities)

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SK-MEL-28 (48833 Activities)

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SK-MEL-5 (47095 Activities)

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SK-OV-3 (52876 Activities)

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SN12C (47755 Activities)

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SNB-19 (46794 Activities)

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TK-10 (45540 Activities)

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U-251 (51189 Activities)

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UACC-257 (46019 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

UACC-62 (47335 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

UO-31 (46270 Activities)

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WI-38 (2654 Activities)

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786-0 (47912 Activities)

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A549 (127892 Activities)

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NCI/ADR-RES (33767 Activities)

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T47D (39041 Activities)

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EKVX (44102 Activities)

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NCI-H322M (45589 Activities)

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HCT-116 (91556 Activities)

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Hs-578T (29457 Activities)

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HepG2 (196354 Activities)

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NCI-H460 (60772 Activities)

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SF-268 (49410 Activities)

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IGROV-1 (47897 Activities)

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LOX IMVI (44321 Activities)

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HOP-62 (47048 Activities)

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Associated Targets(non-human)

pol Human immunodeficiency virus type 1 reverse transcriptase (18245 Activities)

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Hdac6 Histone deacetylase 6 (222 Activities)

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Trypanosoma brucei brucei (13300 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Plasmodium falciparum (966862 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Trichomonas vaginalis (2376 Activities)

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ht1 Hexose transporter 1 (14071 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

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BCHE Cholinesterase (8742 Activities)

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Leishmania mexicana mexicana (27 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)

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SARS-CoV-2 (38078 Activities)

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Names and Identifiers

IUPAC Name	(S)-[(2R,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-quinolin-4-ylmethanol
INCHI	InChI=1S/C19H22N2O/c1-2-13-12-21-10-8-14(13)11-18(21)19(22)16-7-9-20-17-6-4-3-5-15(16)17/h2-7,9,13-14,18-19,22H,1,8,10-12H2/t13-,14-,18+,19-/m0/s1
InChi Key	KMPWYEUPVWOPIM-QAMTZSDWSA-N
Canonical SMILES	C=CC1CN2CCC1CC2C(C3=CC=NC4=CC=CC=C34)O
Isomeric SMILES	C=C[C@H]1CN2CC[C@H]1C[C@@H]2[C@H](C3=CC=NC4=CC=CC=C34)O
WGK Germany	3
RTECS	GD3500000
PubChem CID	90454
Molecular Weight	294.39
Beilstein	89689
Reaxy-Rn	89689

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

Specific Rotation[α]	223 ° (C=0.5, EtOH)
Melt Point(°C)	256-266°C

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H302:Harmful if swallowed H317:May cause an allergic skin reaction H332:Harmful if inhaled
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help. P317:Get emergency medical help.
WGK Germany	3
RTECS	GD3500000
Reaxy-Rn	89689
Merck Index	2287

Citations of This Product

1. Huan Xue, Hao-Jie Xing, Bin Wang, Chao Fu, Yu-Shan Zhang, Xi Qiao, Chao Guo, Xiao-Li Zhang, Bin Hu, Xin Zhao, Li-Jiao Deng, Xiao-Chan Zhu, Yi Zhang, Yun-Feng Liu. (2023) Cinchonine, a Potential Oral Small-Molecule Glucagon-Like Peptide-1 Receptor Agonist, Lowers Blood Glucose and Ameliorates Non-Alcoholic Steatohepatitis. Drug Design Development and Therapy, [PMID:37197367]

References

1. Gamo FJ, Sanz LM, Vidal J, de Cozar C, Alvarez E, Lavandera JL, Vanderwall DE, Green DV, Kumar V, Hasan S et al.. (2010) Thousands of chemical starting points for antimalarial lead identification.. Nature, 465 (7296): (305-10). [PMID:20485427]
2. Olaf Kuhlmann,Hans-Stefan Hofmann,Sylvana P Müller,Michael Weiss. (2003-07-11) Pharmacokinetics of idarubicin in the isolated perfused rat lung: effect of cinchonine and rutin.. Anti-cancer drugs, 14 ((6)): (411-416). [PMID:12853881]
3. Xianhong Wen,Ziyang Liu,Tianqiang Zhu,Miaoqin Zhu,Kezhi Jiang,Qiaoqiao Huang. (2004-06-24) Evidence for the 2:1 molecular recognition and inclusion behaviour between beta- and gamma-cyclodextrins and cinchonine.. Bioorganic chemistry, 32 ((4)): (223-233). [PMID:15210337]
4. Chensong Pan,Songyun Xu,Hanfa Zou,Zhong Guo,Yu Zhang,Baochuan Guo. (2005-02-08) Carbon nanotubes as adsorbent of solid-phase extraction and matrix for laser desorption/ionization mass spectrometry.. Journal of the American Society for Mass Spectrometry, 16 ((2)): (263-270). [PMID:15694776]
5. Qing-Min Xu,Dong Wang,Mei-Juan Han,Li-Jun Wan,Chun-Li Bai. (2005-05-07) Direct STM investigation of cinchona alkaloid adsorption on Cu(III).. Langmuir : the ACS journal of surfaces and colloids, 20 ((8)): (3006-3010). [PMID:15875820]
6. A Louise Tillman,Jinxing Ye,Darren J Dixon. (2006-03-07) Direct enantio- and diastereoselective Mannich reactions of malonate and beta-keto esters with N-Boc and N-Cbz aldimines catalysed by a bifunctional cinchonine derivative.. Chemical communications (Cambridge, England), ((11)(11)): (1191-1193). [PMID:16518487]
7. Iwona Tesarowicz,Barbara J Oleksyn,Wojciech Nitek. (2006-12-08) Crystal and molecular structures of trichloro-cobalt(II) complexes of epiquinine, epiquinidine, and epidihydrocinchonine.. Chirality, 19 ((2)): (152-161). [PMID:17152047]
8. Hirdyesh Mishra,Sanjay Pant,Hera B Tripathi. (2007-08-24) Temperature-dependent time-resolved fluorescence study of cinchonine alkaloid dication.. Journal of fluorescence, 18 ((1)): (17-27). [PMID:17713845]
9. Karol M Kacprzak,Wolfgang Lindner,Norbert M Maier. (2007-09-14) An improved synthesis of 10,11-didehydro Cinchona alkaloids.. Chirality, 20 ((3-4)): (441-445). [PMID:17853397]
10. Jonas Nyhlén,Lars Eriksson,Jan-E Bäckvall. (2007-10-30) Synthesis and optical resolution of an allenoic acid by diastereomeric salt formation induced by chiral alkaloids.. Chirality, 20 ((1)): (47-50). [PMID:17966123]
11. David Plouffe,Achim Brinker,Case McNamara,Kerstin Henson,Nobutaka Kato,Kelli Kuhen,Advait Nagle,Francisco Adrián,Jason T Matzen,Paul Anderson,Tae-Gyu Nam,Nathanael S Gray,Arnab Chatterjee,Jeff Janes,S Frank Yan,Richard Trager,Jeremy S Caldwell,Peter G Schultz,Yingyao Zhou,Elizabeth A Winzeler. (2008-06-27) In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen.. Proceedings of the National Academy of Sciences of the United States of America, 105 ((26)): (9059-9064). [PMID:18579783]
12. Jian Zhang,Shumei Chen,Tao Wu,Pingyun Feng,Xianhui Bu. (2008-09-09) Homochiral crystallization of microporous framework materials from achiral precursors by chiral catalysis.. Journal of the American Chemical Society, 130 ((39)): (12882-12883). [PMID:18774816]
13. Jeremiah P Malerich,Koji Hagihara,Viresh H Rawal. (2008-10-14) Chiral squaramide derivatives are excellent hydrogen bond donor catalysts.. Journal of the American Chemical Society, 130 ((44)): (14416-14417). [PMID:18847268]
14. Péter Király,Tibor Soós,Szilárd Varga,Benedek Vakulya,Gábor Tárkányi. (2009-10-29) Self-association promoted conformational transition of (3R,4S,8R,9R)-9-[(3,5-bis(trifluoromethyl)phenyl))-thiourea](9-deoxy)-epi-cinchonine.. Magnetic resonance in chemistry : MRC, 48 ((1)): (13-19). [PMID:19862796]
15. Aleksandra Wesełucha-Birczyńska,Barbara J Oleksyn,Joanna Watroba. (2009-11-04) Channel-like crystal structure of cinchoninium L-O-phosphoserine salt dihydrate.. Chirality, 22 ((6)): (557-564). [PMID:19885820]
16. Yueqi Liu,Kaori Hoshina,Jun Haginaka. (2010-02-16) Monodispersed, molecularly imprinted polymers for cinchonidine by precipitation polymerization.. Talanta, 80 ((5)): (1713-1718). [PMID:20152401]
17. Francisco J Prado-Prado,Xerardo García-Mera,Humberto González-Díaz. (2010-02-27) Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.. Bioorganic & medicinal chemistry, 18 ((6)): (2225-2231). [PMID:20185316]
18. Edinson Lucumi,Claire Darling,Hyunil Jo,Andrew D Napper,Rajesh Chandramohanadas,Nicholas Fisher,Alison E Shone,Huiyan Jing,Stephen A Ward,Giancarlo A Biagini,William F DeGrado,Scott L Diamond,Doron C Greenbaum. (2010-06-16) Discovery of potent small-molecule inhibitors of multidrug-resistant Plasmodium falciparum using a novel miniaturized high-throughput luciferase-based assay.. Antimicrobial agents and chemotherapy, 54 ((9)): (3597-3604). [PMID:20547797]
19. Zbigniew Karczmarzyk,Teodozja M Lipińska,Waldemar Wysocki,Monika Denisiuk,Katarzyna Piechocka. (2011-09-02) Tosyl esters of cinchonidine and cinchonine alkaloids: the structure-reactivity relationship in the hydrolysis to 9-epibases.. Acta crystallographica. Section C, Crystal structure communications, 67 ((Pt 9)): (o346-o349). [PMID:21881184]
20. Qing Gu,Shu-Li You. (2011-09-15) Desymmetrization of cyclohexadienones via asymmetric Michael reaction catalyzed by cinchonine-derived urea.. Organic letters, 13 ((19)): (5192-5195). [PMID:21913734]
21. Yu-Hua Liao,Xiong-Li Liu,Zhi-Jun Wu,Xi-Lin Du,Xiao-Mei Zhang,Wei-Cheng Yuan. (2012-04-14) Organocatalytic asymmetric conjugate addition of 3-monosubstituted oxindoles to (E)-1,4-diaryl-2-buten-1,4-diones: a strategy for the indirect enantioselective furanylation and pyrrolylation of 3-alkyloxindoles.. Chemistry (Weinheim an der Bergstrasse, Germany), 18 ((21)): (6679-6687). [PMID:22499157]
22. Rishi Ranjan Pandey,Akansha Srivastava,Richa Malasoni,Arshi Naqvi,Ashish Jain,Jagdamba Prasad Maikhuri,Sarvesh Paliwal,Gopal Gupta,Anil Kumar Dwivedi. (2012-08-01) Synthesis of 3-(1-alkyl/aminoalkyl-3-vinyl-piperidin-4-yl)-1-(quinolin-4-yl)-propan-1-ones and their 2-methylene derivatives as potential spermicidal and microbicidal agents.. Bioorganic & medicinal chemistry letters, 22 ((17)): (5735-5738). [PMID:22846917]
23. Carol E Griffin,Jonathan M Hoke,Upeka Samarakoon,Junhui Duan,Jianbing Mu,Michael T Ferdig,David C Warhurst,Roland A Cooper. (2012-08-08) Mutation in the Plasmodium falciparum CRT protein determines the stereospecific activity of antimalarial cinchona alkaloids.. Antimicrobial agents and chemotherapy, 56 ((10)): (5356-5364). [PMID:22869567]
24. Matthew L Beckman,Akula Bala Pramod,Danielle Perley,L Keith Henry. (2013-10-29) Stereoselective inhibition of serotonin transporters by antimalarial compounds.. Neurochemistry international, 73 (98-106). [PMID:24161619]
25. Leeor Zilbermintz,William Leonardi,Sun-Young Jeong,Megan Sjodt,Ryan McComb,Chi-Lee C Ho,Cary Retterer,Dima Gharaibeh,Rouzbeh Zamani,Veronica Soloveva,Sina Bavari,Anastasia Levitin,Joel West,Kenneth A Bradley,Robert T Clubb,Stanley N Cohen,Vivek Gupta,Mikhail Martchenko. (2015-08-28) Identification of agents effective against multiple toxins and viruses by host-oriented cell targeting.. Scientific reports, 5 (13476-13476). [PMID:26310922]
26. Wei Chen,Wei Du,Lei Yue,Rui Li,Yong Wu,Li-Sheng Ding,Ying-Chun Chen. (2007-02-23) Organocatalytic enantioselective indole alkylations of alpha,beta-unsaturated ketones.. Organic & biomolecular chemistry, 5 ((5)): (816-821). [PMID:17315068]
27. Sang-Yun Lee,Yun-Hee Rhee,Soo-Jin Jeong,Hyo-Jeong Lee,Hyo-Jung Lee,Min-Hyung Jung,Sun-Hyung Kim,Eun-Ok Lee,Kwang Seok Ahn,Kyoo Seok Ahn,Sung-Hoon Kim. (2010-03-03) Hydrocinchonine, cinchonine, and quinidine potentiate paclitaxel-induced cytotoxicity and apoptosis via multidrug resistance reversal in MES-SA/DX5 uterine sarcoma cells.. Environmental toxicology, 26 ((4)): (424-431). [PMID:20196146]
28. Jiabing Jiang,Kesheng Song,Zhi Chen,Qi Zhou,Youwen Tang,Fenglong Gu,Xiongjun Zuo,Zhiguang Xu. (2011-05-11) Novel molecularly imprinted microsphere using a single chiral monomer and chirality-matching (S)-ketoprofen template.. Journal of chromatography. A, 1218 ((24)): (3763-3770). [PMID:21555129]
29. Huan Xue, Hao-Jie Xing, Bin Wang, Chao Fu, Yu-Shan Zhang, Xi Qiao, Chao Guo, Xiao-Li Zhang, Bin Hu, Xin Zhao, Li-Jiao Deng, Xiao-Chan Zhu, Yi Zhang, Yun-Feng Liu. (2023) Cinchonine, a Potential Oral Small-Molecule Glucagon-Like Peptide-1 Receptor Agonist, Lowers Blood Glucose and Ameliorates Non-Alcoholic Steatohepatitis. Drug Design Development and Therapy, [PMID:37197367]

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