Selective antagonist of T-type voltage-operated calcium ion channels. Antihistaminergic, antiserotoninergic and antidopaminergic effects in vitro .
Shipped In
Normal
Grade
Moligand™
Action Type
ANTAGONIST, BLOCKER, CHANNEL BLOCKER
Mechanism of action
Histamine H1 receptor antagonist
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Associated Targets
CHP1Tbio Calcineurin B homologous protein 1 0 Activities
1.Teive HA, Troiano AR, Germiniani FM, Werneck LC. (2004) Flunarizine and cinnarizine-induced parkinsonism: a historical and clinical analysis.. Parkinsonism Relat Disord, 10 (4):(243-5). [PMID:15120099]
2.Capellà D, Laporte JR, Castel JM, Tristán C, Cos A, Morales-Olivas FJ. (1988) Parkinsonism, tremor, and depression induced by cinnarizine and flunarizine.. BMJ, 297 (6650):(722-3). [PMID:3147743]
3.Kariya S, Isozaki S, Masubuchi Y, Suzuki T, Narimatsu S. (1995) Possible pharmacokinetic and pharmacodynamic factors affecting parkinsonism inducement by cinnarizine and flunarizine.. Biochem Pharmacol, 50 (10):(1645-50). [PMID:7503767]
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K2229373