Grouped product items

SKU

Size

Availability

Price

Qty

C331127-5mg

5mg

In stock

$117.90

C331127-10mg

10mg

In stock

$177.90

C331127-25mg

25mg

In stock

$400.90

C331127-50mg

50mg

In stock

$720.90

C331127-100mg

100mg

Available within 4-8 weeks(?)

$1,297.90

Basic Description

Synonyms	s3224 \| C16931 \| SR-05000002305 \| AKOS040745795 \| Bufa-20,22-dienolide, 16-(acetyloxy)-14,15-epoxy-3-hydroxy-, (3-beta,5-beta,15-beta,16-beta)- \| Cinobufagine \| 5beta-Bufa-20,22-dienolide, 14,15beta-epoxy-3beta,16beta-dihydroxy-, 16-acetate \| CINOBUFAGIN
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Cinobufagin is a bufanolide steroid with anti-proliferative and pro-apoptotic effects as well as antinociception activity. It has been used in Chinese herbal medicine and has been shown to have clinical applications in a variety of cancers both as an anti
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	Cinobufagin is a specific Na\|+\|/K\|+\|-ATPase inhibitor. About as active as ouabain.

Associated Targets(Human)

ACHE Tclin Acetylcholinesterase (18204 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

BGC-823 (3035 Activities)

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Calu-3 (339 Activities)

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HL-60 (67320 Activities)

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SK-MES-1 (413 Activities)

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A549 (127892 Activities)

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Bel-7402 (4577 Activities)

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NCI-H1299 (3248 Activities)

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HepG2 (196354 Activities)

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NCI-H460 (60772 Activities)

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KB (17409 Activities)

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HeLa (62764 Activities)

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HL (112 Activities)

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Liver (3974 Activities)

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ATAD5 Tbio ATPase family AAA domain-containing protein 5 (122566 Activities)

Discover Target: ATAD5

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CLCN3 Tchem H(+)/Cl(-) exchange transporter 3 (23 Activities)

Discover Target: CLCN3

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Associated Targets(non-human)

CCRF S-180 (1031 Activities)

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MH60 (82 Activities)

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H22 (575 Activities)

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BCHE Cholinesterase (8742 Activities)

Discover Target: BCHE

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Liver microsome (341 Activities)

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Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	[(1R,2S,4R,5R,6R,7R,10S,11S,14S,16R)-14-hydroxy-7,11-dimethyl-6-(6-oxopyran-3-yl)-3-oxapentacyclo[8.8.0.02,4.02,7.011,16]octadecan-5-yl] acetate
INCHI	InChI=1S/C26H34O6/c1-14(27)31-22-21(15-4-7-20(29)30-13-15)25(3)11-9-18-19(26(25)23(22)32-26)6-5-16-12-17(28)8-10-24(16,18)2/h4,7,13,16-19,21-23,28H,5-6,8-12H2,1-3H3/t16-,17+,18+,19-,21+,22-,23-,24+,25-,26-/m1/s1
InChi Key	SCULJPGYOQQXTK-OLRINKBESA-N
Canonical SMILES	CC(=O)OC1C(C2(CCC3C(C24C1O4)CCC5C3(CCC(C5)O)C)C)C6=COC(=O)C=C6
Isomeric SMILES	CC(=O)O[C@@H]1[C@@H]([C@]2(CC[C@H]3[C@H]([C@@]24[C@@H]1O4)CC[C@H]5[C@@]3(CC[C@@H](C5)O)C)C)C6=COC(=O)C=C6
WGK Germany	3
RTECS	EI2955000
PubChem CID	11969542
Molecular Weight	442.54

Certificates

Certificate of Analysis(COA)

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Find and download the COA for your product by matching the lot number on the packaging.

5 results found

Lot Number	Certificate Type	Date	Item
K2218380	Certificate of Analysis	Aug 29, 2022	C331127
K2218381	Certificate of Analysis	Aug 29, 2022	C331127
K2218382	Certificate of Analysis	Aug 29, 2022	C331127
K2218383	Certificate of Analysis	Aug 29, 2022	C331127
K2218384	Certificate of Analysis	Aug 29, 2022	C331127

Chemical and Physical Properties

Solubility	Soluble in chloroform, and water (partly).
Sensitivity	heat sensitive
Refractive Index	n20D1.60 (Predicted)
Boil Point(°C)	595.42° C at 760 mmHg (Predicted)
Melt Point(°C)	~211° C

Safety and Hazards(GHS)

Pictogram(s)	GHS06
Signal	Danger
Hazard Statements	H300:Fatal if swallowed H310:Fatal in contact with skin H330:Fatal if inhaled
Precautionary Statements	P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P284:[In case of inadequate ventilation] Wear respiratory protection. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P330:Rinse mouth. P262:Do not get in eyes, on skin, or on clothing. P320:Specific treatment is urgent (see ... on this label). P361+P364:Take off immediately all contaminated clothing and wash it before reuse. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P316:Get emergency medical help immediately.
WGK Germany	3
RTECS	EI2955000

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Cinobufagin - 98%, high purity , CAS No.470-37-1

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

Solution Calculators

Molarity Calculator

Dilution Calculator

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