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Ciprofloxacin hydrochloride - ≥97%, high purity , Topoisomerase IV, CAS No.86483-48-9, Topoisomerase IV

17 Citations

≥97%

CAS#: 86483-48-9
Formula: C₁₇H₁₉ClFN₃O₃
Molecular Weight: 367.8
MDL number: MFCD00079044
PubChem CID: 62999

Item Number

C304792

Grouped product items
SKU	Size	Availability	Price
C304792-25g	25g	In stock	$10.90
C304792-100g	100g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$20.90
C304792-500g	500g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$58.90

Basic Description

Synonyms	Ciprofloxacin hydrochloride \| 93107-08-5 \| Ciprofloxacin HCl \| 86483-48-9 \| 1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride \| Cipro \| Ciprofloxacin Hydrochloride Anhydrous \| CHEBI:310388 \| 0MP32MFP6C \| 1-cyclopropyl-6-fl
Specifications & Purity	≥97%
Storage Temp	Protected from light,Store at -20°C,Desiccated
Shipped In	Ice chest + Ice pads
Action Type	INHIBITOR
Mechanism of action	Topoisomerase IV

Associated Targets(Human)

GALC Tbio Galactocerebrosidase (0 Activities)

Discover Target: GALC

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TOP2B Tclin DNA topoisomerase 2-beta (0 Activities)

Discover Target: TOP2B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (0 Activities)

Discover Target: TDP1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TOP2B Tclin DNA topoisomerase II beta (959 Activities)

Discover Target: TOP2B

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

Discover Target: TDP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Galc Galactocerebrosidase (11 Activities)

Discover Target: Galc

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Streptococcus pneumoniae (31063 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Pseudomonas aeruginosa (123386 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Fusarium solani (1274 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Klebsiella pneumoniae (43867 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Staphylococcus aureus (210822 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Staphylococcus epidermidis (22802 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Acinetobacter baumannii (41033 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Escherichia coli (133304 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Klebsiella oxytoca (929 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Streptococcus pyogenes (16140 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Enterococcus faecium (13803 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Aspergillus flavus (8875 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Listeria monocytogenes (2626 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Enterococcus faecalis (29875 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Penicillium chrysogenum (1593 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Candida albicans (78123 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rattus norvegicus (775804 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Salmonella enterica (1497 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

L6 (7924 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Bacillus anthracis (2936 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Stachybotrys chartarum (30 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

gyrB DNA gyrase (2092 Activities)

Discover Target: gyrB

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	1-cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid;hydrochloride
INCHI	InChI=1S/C17H18FN3O3.ClH/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24;/h7-10,19H,1-6H2,(H,23,24);1H
InChi Key	DIOIOSKKIYDRIQ-UHFFFAOYSA-N
Canonical SMILES	C1CC1N2C=C(C(=O)C3=CC(=C(C=C32)N4CCNCC4)F)C(=O)O.Cl
Isomeric SMILES	C1CC1N2C=C(C(=O)C3=CC(=C(C=C32)N4CCNCC4)F)C(=O)O.Cl
Alternate CAS	93107-08-5
PubChem CID	62999
Molecular Weight	367.8

Certificates

Certificate of Analysis(COA)

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To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

6 results found

Lot Number	Certificate Type	Date	Item
E2407066	Certificate of Analysis	Oct 10, 2023	C304792
J2308434	Certificate of Analysis	Oct 10, 2023	C304792
J2308435	Certificate of Analysis	Oct 10, 2023	C304792
J2308432	Certificate of Analysis	Oct 10, 2023	C304792
J2308433	Certificate of Analysis	Oct 10, 2023	C304792
J2308436	Certificate of Analysis	Oct 10, 2023	C304792

Chemical and Physical Properties

Sensitivity	light sensitive
Melt Point(°C)	>300℃

Safety and Hazards(GHS)

Pictogram(s)	GHS08, GHS09, GHS07
Signal	Danger
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H411:Toxic to aquatic life with long lasting effects H317:May cause an allergic skin reaction H334:May cause allergy or asthma symptoms or breathing difficulties if inhaled H400:Very toxic to aquatic life H410:Very toxic to aquatic life with long lasting effects
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P284:[In case of inadequate ventilation] Wear respiratory protection. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P391:Collect spillage. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. P342+P316:If experiencing respiratory symptoms: Get emergence medical help immediately.

Citations of This Product

1. Zhang Wenqin, Cai Xiaozhen, Zhang Xinyi, Zou Shiqi, Zhu Danhong, Zhang Qiulong, Chen Jianmin. (2023) AgNPs-Modified Polylactic Acid Microneedles: Preparation and In Vivo/In Vitro Antimicrobial Studies. PHARMACEUTICAL RESEARCH, (1-12). [PMID:37985572]
2. Jun Yao. (2024) A multiple signal amplification photoelectrochemical biosensor based on biotin-avidin system for kanamycin sensing in fish and milk via synergism of g-C3N4 and Ru@SiO2. ANALYTICA CHIMICA ACTA, 1288 (342141). [PMID:38220276]
3. Yulong Chen, Yuan Chi, Xiao Wu, Cong Lin, Tengfei Lin, Min Gao, Chunlin Zhao, Baisheng Sa. (2023) O-Vacancy-Rich ε-MnO2 Synthesized at Hydrophobic Interface: An Efficient Fenton-like Catalyst for Removing Ciprofloxacin from Water. Crystals, 13 (12): (1664). [PMID:]
4. Xiaojing Qin, Weibo Meng, Song Cheng, Baolin Xing, Changliang Shi, Yanhe Nie, Qiang Wang, Hongying Xia. (2023) Efficient removal of heavy metal and antibiotics from wastewater by phosphate-modified hydrochar. CHEMOSPHERE, 345 (23): (140484). [PMID:37863206]
5. Xu Liu, Xiao Han, Yushuang Shang, Lijuan Wang, Jian Shen, Jiang Yuan. (2023) Hydrogen sulfide releasing poly(γ-glutamic acid) biocomposite hydrogel with monitoring, antioxidant, and antibacterial properties for diabetic wound healing. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 253 (1): (127053). [PMID:37774813]
6. Qing Zhang, Lin Zhang, Yuhan Zhang, Yi Wang, Rong Ju, Guoqing Wei. (2023) Repolarization of Inflammation-Associated Macrophages by Dual Drug-Loaded Liposomes for Acute Lung Sepsis Antibacterial and Anti-inflammatory Therapy. ACS Applied Nano Materials, 6 (17): (15829–15840). [PMID:]
7. Haiping Wang, Xueren Qian, Xianhui An. (2023) Visual fluorescence detection of ciprofloxacin by Zn-metal-organic framework@nanocellulose transparent films based on aggregation-induced emission. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 251 (126363). [PMID:37595728]
8. Yuanqian Xiong, Dong Zhang, Cuizhu Ye, Yu Wang, Xiangrui Deng, Danwen Deng, Chunhong Xiong, Jinsheng Zhang, Qianhui Gu, Ganhui Huang. (2023) Ultra-sensitive detection of ciprofloxacin hydrochloride in milk by molecularly imprinted electrochemical sensor based on S-CoFe-MOFs/AuNPs. JOURNAL OF FOOD COMPOSITION AND ANALYSIS, 122 (105439). [PMID:]
9. Huifang Wu, Shiying Ju, Yuwei Ling, Haozhe Sun, Yanfeng Tang, Changlun Tong. (2023) Gelatinous lanthanide coordination polymer with aggregation-enhanced antenna effect for ratiometric detection of endogenous alkaline phosphatase. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 645 (338). [PMID:37150007]
10. Wangjing Zhai, Wenqi Jiang, Qiqi Guo, Zhixuan Wang, Donghui Liu, Zhiqiang Zhou, Peng Wang. (2023) Existence of antibiotic pollutant in agricultural soil: Exploring the correlation between microbiome and pea yield. SCIENCE OF THE TOTAL ENVIRONMENT, 871 (162152). [PMID:36775170]
11. Dan Li, Danyang Wang, Ye He, Bailong Tao, Xiaoxia Liu, Yulu Yang, Lu Tan, Yuchen Zhang, Jingwei Hu, Weihu Yang, Yu Tang, Kaiyong Cai. (2023) A HAase/NIR responsive surface on titanium implants for treating bacterial infection and improving osseointegration. JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY, 143 (93). [PMID:]
12. Yu Wang, Yunxiang He, Qin Wang, Xiaoling Wang, Blaise L. Tardy, Joseph J. Richardson, Orlando J. Rojas, Junling Guo. (2023) Microporous membranes for ultrafast and energy-efficient removal of antibiotics through polyphenol-mediated nanointerfaces. Matter, 6 (260-273). [PMID:]
13. Tongyao Lin, Jinglin Zhang, Hui Long, Fengjuan Yang, Langhuan Huang, Sui-Ping Deng, Jingxian Zhang, Xiang Cai, Yunhua Yang, Shaozao Tan. (2022) Temperature-Sensitive Hydrogels Containing Carboxylated Chitosan-Modified Carbon Nanotubes for Controlled Drug Release. ACS Applied Nano Materials, 5 (8): (10409–10420). [PMID:]
14. Xu Junge, Hu Die, Wang Yingmu, Zhang Ziwei. (2022) α-(Fe, Cu)OOH/RGO nanocomposites for heterogeneous photo-Fenton-like degradation of ciprofloxacin under visible light irradiation. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 29 (52): (78874-78886). [PMID:35697989]
15. Yongwu He, Songling Han, Gaomei Zhao, Jiaohua Luo, Changsheng Jia, Yin Chen, Qi Liu, Jining Gao, Cheng Wang, Junping Wang. (2022) Zinc oxide-coated carboxyl-riched graphene oxide efficiently degrades microcystin-leucine arginine and antibiotics under visible light. Journal of Environmental Chemical Engineering, 10 (107829). [PMID:]
16. Chang Ping Yang, Cong Yi Hu, Zhong Wei Jiang, Si Yu Xiao, Xiao Yan Wang, Cheng Zhi Huang, Yuan Fang Li, Shu Jun Zhen. (2022) Facile synthesis of porphyrin-MOFs with high photo-Fenton activity to efficiently degrade ciprofloxacin. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 622 (690). [PMID:35533483]
17. Yafang Shen, Fei Jia, Aoming Liang, Yawen He, Yaping Peng, Huang Dai, Yingchun Fu, Jianping Wang, Yanbin Li. (2022) Monovalent Antigen-Induced Aggregation (MAA) Biosensors Using Immunomagnetic Beads in Both Sample Separation and Signal Generation for Label-Free Detection of Enrofloxacin. ACS Applied Materials & Interfaces, 14 (7): (8816–8823). [PMID:35133806]

References

1. Zhang Wenqin, Cai Xiaozhen, Zhang Xinyi, Zou Shiqi, Zhu Danhong, Zhang Qiulong, Chen Jianmin. (2023) AgNPs-Modified Polylactic Acid Microneedles: Preparation and In Vivo/In Vitro Antimicrobial Studies. PHARMACEUTICAL RESEARCH, (1-12). [PMID:37985572]
2. Jun Yao. (2024) A multiple signal amplification photoelectrochemical biosensor based on biotin-avidin system for kanamycin sensing in fish and milk via synergism of g-C3N4 and Ru@SiO2. ANALYTICA CHIMICA ACTA, 1288 (342141). [PMID:38220276]
3. Yulong Chen, Yuan Chi, Xiao Wu, Cong Lin, Tengfei Lin, Min Gao, Chunlin Zhao, Baisheng Sa. (2023) O-Vacancy-Rich ε-MnO2 Synthesized at Hydrophobic Interface: An Efficient Fenton-like Catalyst for Removing Ciprofloxacin from Water. Crystals, 13 (12): (1664). [PMID:]
4. Xiaojing Qin, Weibo Meng, Song Cheng, Baolin Xing, Changliang Shi, Yanhe Nie, Qiang Wang, Hongying Xia. (2023) Efficient removal of heavy metal and antibiotics from wastewater by phosphate-modified hydrochar. CHEMOSPHERE, 345 (23): (140484). [PMID:37863206]
5. Xu Liu, Xiao Han, Yushuang Shang, Lijuan Wang, Jian Shen, Jiang Yuan. (2023) Hydrogen sulfide releasing poly(γ-glutamic acid) biocomposite hydrogel with monitoring, antioxidant, and antibacterial properties for diabetic wound healing. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 253 (1): (127053). [PMID:37774813]
6. Qing Zhang, Lin Zhang, Yuhan Zhang, Yi Wang, Rong Ju, Guoqing Wei. (2023) Repolarization of Inflammation-Associated Macrophages by Dual Drug-Loaded Liposomes for Acute Lung Sepsis Antibacterial and Anti-inflammatory Therapy. ACS Applied Nano Materials, 6 (17): (15829–15840). [PMID:]
7. Haiping Wang, Xueren Qian, Xianhui An. (2023) Visual fluorescence detection of ciprofloxacin by Zn-metal-organic framework@nanocellulose transparent films based on aggregation-induced emission. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 251 (126363). [PMID:37595728]
8. Yuanqian Xiong, Dong Zhang, Cuizhu Ye, Yu Wang, Xiangrui Deng, Danwen Deng, Chunhong Xiong, Jinsheng Zhang, Qianhui Gu, Ganhui Huang. (2023) Ultra-sensitive detection of ciprofloxacin hydrochloride in milk by molecularly imprinted electrochemical sensor based on S-CoFe-MOFs/AuNPs. JOURNAL OF FOOD COMPOSITION AND ANALYSIS, 122 (105439). [PMID:]
9. Huifang Wu, Shiying Ju, Yuwei Ling, Haozhe Sun, Yanfeng Tang, Changlun Tong. (2023) Gelatinous lanthanide coordination polymer with aggregation-enhanced antenna effect for ratiometric detection of endogenous alkaline phosphatase. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 645 (338). [PMID:37150007]
10. Wangjing Zhai, Wenqi Jiang, Qiqi Guo, Zhixuan Wang, Donghui Liu, Zhiqiang Zhou, Peng Wang. (2023) Existence of antibiotic pollutant in agricultural soil: Exploring the correlation between microbiome and pea yield. SCIENCE OF THE TOTAL ENVIRONMENT, 871 (162152). [PMID:36775170]
11. Dan Li, Danyang Wang, Ye He, Bailong Tao, Xiaoxia Liu, Yulu Yang, Lu Tan, Yuchen Zhang, Jingwei Hu, Weihu Yang, Yu Tang, Kaiyong Cai. (2023) A HAase/NIR responsive surface on titanium implants for treating bacterial infection and improving osseointegration. JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY, 143 (93). [PMID:]
12. Yu Wang, Yunxiang He, Qin Wang, Xiaoling Wang, Blaise L. Tardy, Joseph J. Richardson, Orlando J. Rojas, Junling Guo. (2023) Microporous membranes for ultrafast and energy-efficient removal of antibiotics through polyphenol-mediated nanointerfaces. Matter, 6 (260-273). [PMID:]
13. Tongyao Lin, Jinglin Zhang, Hui Long, Fengjuan Yang, Langhuan Huang, Sui-Ping Deng, Jingxian Zhang, Xiang Cai, Yunhua Yang, Shaozao Tan. (2022) Temperature-Sensitive Hydrogels Containing Carboxylated Chitosan-Modified Carbon Nanotubes for Controlled Drug Release. ACS Applied Nano Materials, 5 (8): (10409–10420). [PMID:]
14. Xu Junge, Hu Die, Wang Yingmu, Zhang Ziwei. (2022) α-(Fe, Cu)OOH/RGO nanocomposites for heterogeneous photo-Fenton-like degradation of ciprofloxacin under visible light irradiation. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 29 (52): (78874-78886). [PMID:35697989]
15. Yongwu He, Songling Han, Gaomei Zhao, Jiaohua Luo, Changsheng Jia, Yin Chen, Qi Liu, Jining Gao, Cheng Wang, Junping Wang. (2022) Zinc oxide-coated carboxyl-riched graphene oxide efficiently degrades microcystin-leucine arginine and antibiotics under visible light. Journal of Environmental Chemical Engineering, 10 (107829). [PMID:]
16. Chang Ping Yang, Cong Yi Hu, Zhong Wei Jiang, Si Yu Xiao, Xiao Yan Wang, Cheng Zhi Huang, Yuan Fang Li, Shu Jun Zhen. (2022) Facile synthesis of porphyrin-MOFs with high photo-Fenton activity to efficiently degrade ciprofloxacin. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 622 (690). [PMID:35533483]
17. Yafang Shen, Fei Jia, Aoming Liang, Yawen He, Yaping Peng, Huang Dai, Yingchun Fu, Jianping Wang, Yanbin Li. (2022) Monovalent Antigen-Induced Aggregation (MAA) Biosensors Using Immunomagnetic Beads in Both Sample Separation and Signal Generation for Label-Free Detection of Enrofloxacin. ACS Applied Materials & Interfaces, 14 (7): (8816–8823). [PMID:35133806]

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