Potent GluN2C/GluN2D (formerly NR2C / NR2D)-preferring NMDA receptor antagonist. (K i values for recombinant rat receptors are 0.096 (NR2C), 0.125 (NR2D), 0.55 (NR2A) and 0.31 μM (NR2B)).
Storage Temp
Store at 2-8°C,Desiccated
Shipped In
Wet ice
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
1.Zhang Z & Sun QQ. (2011) Development of NMDA NR2 subunits and their roles in critical period maturation of neocortical GABAergic interneurons.. Dev Neurobiol, 71 (3):(221-45). [PMID:20936660]
2.Harney SC et al.. (2008) Extrasynaptic NR2D-containing NMDARs are recruited to the synapse during LTP of NMDAR-EPSCs.. J Neurosci, 28 (45):(11685-94). [PMID:18987204]
3.Pregno G et al.. (2011) Neuregulin1/ErbB4-induced migration in ST14A striatal progenitors: calcium-dependent mechanisms and modulation by NMDA receptor activation.. BMC Neurosci, 12 (103). [PMID:21991932]
4.Doyle S et al.. (2018) Vesicular glutamate release from central axons contributes to myelin damage.. Nat Commun, 9 (1032). [PMID:29531223]
5.Sun QQ & Zhang Z. (2011) Whisker experience modulates long-term depression in neocortical ?-aminobutyric acidergic interneurons in barrel cortex.. J Neurosci Res, 89 (73-85). [PMID:21046566]
Solution Calculators
Molarity Calculator
Determine the necessary mass, volume, or concentration for preparing a solution.
Dilution Calculator
Determine the dilution needed to prepare a stock solution.
