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Citrate - analytical standard, high purity , CAS No.77-92-9, Activator of TRPP2;Activator of TRPV4
Basic Description Synonyms citric acid|77-92-9|Citric acid, anhydrous|2-hydroxypropane-1,2,3-tricarboxylic acid|Anhydrous citric acid|Aciletten|Citro|Citretten|Chemfill|Hydrocerol A|Citric acid anhydrous|1,2,3-Propanetricarboxylic acid, 2-hydroxy-|Kyselina citronova|2-hydroxy-1,2,3 Specifications & Purity Moligand™, analytical standard Shipped In Normal Grade analytical standard, Moligand™ Action Type ACTIVATOR Mechanism of action Activator of TRPP2;Activator of TRPV4 Product Description Citric Acid is an acidic compound from citrus fruits; as a starting point in the Krebs cycle, citrate is a key intermediate in metabolism. Citric acid is one of a series of compounds responsible for the physiological oxidation of fats, carbohydrates and proteins to carbon dioxide and water. Often used to prepare citrate buffer for antigen retrieval of tissue samples. The citrate solution is designed to break protein cross-links; thus, unmasking antigens and epitopes in formalin-fixed and paraffin embedded tissue sections, resulting in enhancing staining intensity of antibodies. Citrate has anticoagulant activity; as a calcium chelator, it forms complexes that disrupt the tendency of blood to clot. May be used to adjust pH and as a sequestering agent for the removal of trace metals.
Names and Identifiers IUPAC Name 2-hydroxypropane-1,2,3-tricarboxylic acid INCHI InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12) InChi Key KRKNYBCHXYNGOX-UHFFFAOYSA-N Canonical SMILES C(C(=O)O)C(CC(=O)O)(C(=O)O)O Isomeric SMILES C(C(=O)O)C(CC(=O)O)(C(=O)O)O WGK Germany 1 RTECS GE7350000 PubChem CID 311 Molecular Weight 192.12 Beilstein 782061
Chemical and Physical Properties Solubility Soluble in alcohol, water (750 mg/ml at 20 °C), and methanol. Insoluble in chloroform, and benzenz. Melt Point(°C) 153-159°C
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P362+P364: Take off contaminated clothing and wash it before reuse.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P337+P317: If eye irritation persists: Get medical help.
P332+P317: If skin irritation occurs: Get medical help.
P319: Get medical help if you feel unwell.
WGK Germany 1 RTECS GE7350000 Merck Index 2326
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I2214149