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CL-387785 - 10mM in DMSO, high purity , CAS No.194423-06-8
an irreversible inhibitor of EGF-receptor kinase activity
Basic Description Synonyms cl-387785 | 194423-06-8 | EKI-785 | N-(4-((3-bromophenyl)amino)quinazolin-6-yl)but-2-ynamide | CL-387,785 | N-[4-[(3-Bromophenyl)amino]-6-quinazolinyl]-2-butynamide | CL-387785 (EKI-785) | EKB-785 | WAY-EKI-785 | CL 387785 | CL-387785(EKI785; WAY-EKI 785) | N-[4-(3-bromoanilin Specifications & Purity 10mM in DMSO Storage Temp Store at -80°C Shipped In Ice chest + Ice pads Product Description CL-387,785 irreversibly inhibits EGF-receptor (EGFR) kinase activity as well as EGF-stimulated autophosphorylation of tyrosine residues in the EGFR. CL-387,785 also blocks EGF-mediated growth in A431 cells. The compound inhibits proliferation of EGFR or c-ErbB2 expressing cells by covalently binding to the EGFR.
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name N-[4-(3-bromoanilino)quinazolin-6-yl]but-2-ynamide INCHI InChI=1S/C18H13BrN4O/c1-2-4-17(24)22-14-7-8-16-15(10-14)18(21-11-20-16)23-13-6-3-5-12(19)9-13/h3,5-11H,1H3,(H,22,24)(H,20,21,23) InChi Key BTYYWOYVBXILOJ-UHFFFAOYSA-N Canonical SMILES CC#CC(=O)NC1=CC2=C(C=C1)N=CN=C2NC3=CC(=CC=C3)Br Isomeric SMILES CC#CC(=O)NC1=CC2=C(C=C1)N=CN=C2NC3=CC(=CC=C3)Br PubChem CID 2776 Molecular Weight 381.2
Chemical and Physical Properties Sensitivity Heat sensitive Melt Point(°C) 276 °C
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