Determine the necessary mass, volume, or concentration for preparing a solution.
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SKU | Size | Availability | Price | Qty |
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C434243-2ml | 2ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $467.90 |
Synonyms | 6-O-methyl erythromycin | CLARITHROMYCIN (USP IMPURITY) | CLARITHROMYCIN [INN] | DTXCID40820062 | 8-Hydroxy-3,4-dihydrocarbstyril | CAS-81103-11-9 | Clacee | Bicrolid | Boc-Leu-OH.H2O | CLARITHROMYCIN (USP-RS) | (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-(((2S |
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Specifications & Purity | Moligand™, 50 mg/mL in DMSO |
Biochemical and Physiological Mechanisms | Macrolides, such as clarithromycin, prevent protein synthesis in bacteria, by binding to 50S ribosomal subunit. It also binds to other ribosomal proteins, and prevents the translocation of pepti-dyl-tRNA. In patients with refractory asthma, it is capable |
Storage Temp | Store at -20°C,Desiccated |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Product Description | General Description Clarithromycin is a macrolide antibiotic, which has both antibacterial and anti-inflammatory actions. It is a semi-synthetic 14-membered derivative of erythromycin A, which is resistant to degradation under acidic conditions. Application Clarithromycin may be used for- the study of the effects of clarithromycin on rate-dependent changes in QT, T p-e and proarrhythmic events performed on arterially perfused rabbit left ventricular wedge preparations the culture of parasites expressing GFP (green fluorescence protein) targeted to the apicoplast, to be further used for microscopy-based assays the study of the synergism of NAB741 with clarithromycin in microtiter plates. Other Notes Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Combustible liquids |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-12,13-dihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-7-methoxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione |
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INCHI | InChI=1S/C38H69NO13/c1-15-26-38(10,45)31(42)21(4)28(40)19(2)17-37(9,47-14)33(52-35-29(41)25(39(11)12)16-20(3)48-35)22(5)30(23(6)34(44)50-26)51-27-18-36(8,46-13)32(43)24(7)49-27/h19-27,29-33,35,41-43,45H,15-18H2,1-14H3/t19-,20-,21+,22+,23-,24+,25+,26-,27+,29-,30+,31-,32+,33-,35+,36-,37-,38-/m1/s1 |
InChi Key | AGOYDEPGAOXOCK-KCBOHYOISA-N |
Canonical SMILES | CCC1C(C(C(C(=O)C(CC(C(C(C(C(C(=O)O1)C)OC2CC(C(C(O2)C)O)(C)OC)C)OC3C(C(CC(O3)C)N(C)C)O)(C)OC)C)C)O)(C)O |
Isomeric SMILES | CC[C@@H]1[C@@]([C@@H]([C@H](C(=O)[C@@H](C[C@@]([C@@H]([C@H]([C@@H]([C@H](C(=O)O1)C)O[C@H]2C[C@@]([C@H]([C@@H](O2)C)O)(C)OC)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)(C)OC)C)C)O)(C)O |
WGK Germany | 3 |
RTECS | KF4997000 |
Alternate CAS | 81103-11-9,116836-41-0 |
PubChem CID | 84029 |
NSC Number | 758704 |
MeSH Entry Terms | 6-O-Methylerythromycin;A 56268;A-56268;A56268;Biaxin;Clarithromycin;TE 031;TE-031;TE031 |
Molecular Weight | 747.95 |
Enter Lot Number to search for COA:
Specific Rotation[α] | -92°C |
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Melt Point(°C) | 225°C |
Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H302:Harmful if swallowed |
Precautionary Statements | P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help. |
WGK Germany | 3 |
RTECS | KF4997000 |
Merck Index | 2339 |
1. Xiaoyu Zhang, Peiran Meng, Wei Wang, Xiwen Li, Zuan Yang, Shaokai Du, Yue Sun. (2023) Simultaneous Electrochemical Determination of Erythromycin and Hemoglobin by Flexible Carbon Cloth Modified with ZnO Nanorod Arrays and Au Nanoparticles by Differential Pulse Voltammetry (DPV). ANALYTICAL LETTERS, [PMID:] [10.1080/00032719.2023.2292664] |
2. Qin Tang, Zhengcai Ma, Xiang Tang, Yan Liu, Huimin Wu, Yu Peng, Baihua Jiao, Rui Wang, Xiaoli Ye, Hang Ma, Xuegang Li. (2023) Coptisine inhibits Helicobacter pylori and reduces the expression of CagA to alleviate host inflammation in vitro and in vivo. JOURNAL OF ETHNOPHARMACOLOGY, (116618). [PMID:37164257] [10.1016/j.jep.2023.116618] |
3. Ruoyu Deng, Dongxu Yang, Mengli Chen, Qiang He, Qingjuan He, Yi Chen. (2023) The enhancing energy efficiency of sulfadiazine degradation using a DBD-contact plasma treatment process. CHEMICAL ENGINEERING JOURNAL, 463 (142491). [PMID:] [10.1016/j.cej.2023.142491] |
4. Chong Yu, Chi Li, Ying Zhang, Xiang Du, Jing-Han Wang, Zhan-You Chi, Qian Zhang. (2023) Effects of environment-relevant concentrations of antibiotics on seawater Chlorella sp. biofilm in artificial mariculture effluent. Algal Research-Biomass Biofuels and Bioproducts, 70 (103008). [PMID:] [10.1016/j.algal.2023.103008] |
5. Yu Wang, Yunxiang He, Qin Wang, Xiaoling Wang, Blaise L. Tardy, Joseph J. Richardson, Orlando J. Rojas, Junling Guo. (2023) Microporous membranes for ultrafast and energy-efficient removal of antibiotics through polyphenol-mediated nanointerfaces. Matter, 6 (260-273). [PMID:] [10.1016/j.matt.2022.09.021] |
6. Wan-Feng Xu, Yun Wang, Hai Huang, Jia-Wei Wu, Yuan Che, Chu-Jie Ding, Quan Zhang, Wei-Ling Cao, Li-Juan Cao. (2022) Octreotide-based therapies effectively protect mice from acute and chronic gastritis. EUROPEAN JOURNAL OF PHARMACOLOGY, 928 (174976). [PMID:35487253] [10.1016/j.ejphar.2022.174976] |
7. Ling Li, Yaoyao Du, Yang Wang, Ning He, Bing Wang, Tong Zhang. (2022) Atractylone Alleviates Ethanol-Induced Gastric Ulcer in Rat with Altered Gut Microbiota and Metabolites. Journal of Inflammation Research, [PMID:35996682] [10.2147/JIR.S372389] |
8. Shuting Zeng, Jing Sun, Ziwei Chen, Qiuxiang Xu, Wei Wei, Dongbo Wang, Bing-Jie Ni. (2021) The impact and fate of clarithromycin in anaerobic digestion of waste activated sludge for biogas production. ENVIRONMENTAL RESEARCH, 195 (110792). [PMID:33545126] [10.1016/j.envres.2021.110792] |
9. Xueqing Guo, Yang Liu, Wenjuan Dong, Qin Hu, Yong Li, Shaomin Shuang, Chuan Dong, Lishuai Cai, Xiaojuan Gong. (2021) Azithromycin detection in cells and tablets by N,S co-doped carbon quantum dots. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 252 (119506). [PMID:33561684] [10.1016/j.saa.2021.119506] |
10. Zhou Chen, Yanzeng Li, Yanyan Peng, Chengsong Ye, Shenghua Zhang. (2021) Effects of antibiotics on hydrolase activity and structure of microbial community during aerobic co-composting of food waste with sewage sludge. BIORESOURCE TECHNOLOGY, 321 (124506). [PMID:33310386] [10.1016/j.biortech.2020.124506] |
11. Yuanna Shen, Yiqing Zou, Xiaonan Chen, Pengyu Li, Yiqin Rao, Xuan Yang, Yingying Sun, Haiyan Hu. (2020) Antibacterial self-assembled nanodrugs composed of berberine derivatives and rhamnolipids against Helicobacter pylori. JOURNAL OF CONTROLLED RELEASE, 328 (575). [PMID:32946873] [10.1016/j.jconrel.2020.09.025] |
12. Ziming Zhao, Yanzhu Guo, Tao Zhang, Jiliang Ma, Haiming Li, Jinghui Zhou, Zhiwei Wang, Runcang Sun. (2020) Preparation of carbon dots from waste cellulose diacetate as a sensor for tetracycline detection and fluorescence ink. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 164 (4289). [PMID:32891644] [10.1016/j.ijbiomac.2020.08.243] |
13. Yunlei Zhou, Fei Li, Hanwen Wu, Yan Chen, Huanshun Yin, Shiyun Ai, Jun Wang. (2019) Electrochemical aptasensing strategy for kanamycin detection based on target-triggered single-strand DNA adsorption on MoS2 nanosheets and enzymatic signal amplification. SENSORS AND ACTUATORS B-CHEMICAL, 296 (126664). [PMID:] [10.1016/j.snb.2019.126664] |
14. Pengyu Li, Xiaonan Chen, Yuanna Shen, Huatian Li, Yiqing Zou, Gang Yuan, Ping Hu, Haiyan Hu. (2019) Mucus penetration enhanced lipid polymer nanoparticles improve the eradication rate of Helicobacter pylori biofilm. JOURNAL OF CONTROLLED RELEASE, 300 (52). [PMID:30825476] [10.1016/j.jconrel.2019.02.039] |
1. Eric H Ekland, Jessica Schneider, David A Fidock,. (2011-07-13) Identifying apicoplast-targeting antimalarials using high-throughput compatible approaches.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 25 ((10)): ( 3583-3593 ). [PMID:21746861] |
2. Xiaoyu Zhang, Peiran Meng, Wei Wang, Xiwen Li, Zuan Yang, Shaokai Du, Yue Sun. (2023) Simultaneous Electrochemical Determination of Erythromycin and Hemoglobin by Flexible Carbon Cloth Modified with ZnO Nanorod Arrays and Au Nanoparticles by Differential Pulse Voltammetry (DPV). ANALYTICAL LETTERS, [PMID:] [10.1080/00032719.2023.2292664] |
3. Qin Tang, Zhengcai Ma, Xiang Tang, Yan Liu, Huimin Wu, Yu Peng, Baihua Jiao, Rui Wang, Xiaoli Ye, Hang Ma, Xuegang Li. (2023) Coptisine inhibits Helicobacter pylori and reduces the expression of CagA to alleviate host inflammation in vitro and in vivo. JOURNAL OF ETHNOPHARMACOLOGY, (116618). [PMID:37164257] [10.1016/j.jep.2023.116618] |
4. Ruoyu Deng, Dongxu Yang, Mengli Chen, Qiang He, Qingjuan He, Yi Chen. (2023) The enhancing energy efficiency of sulfadiazine degradation using a DBD-contact plasma treatment process. CHEMICAL ENGINEERING JOURNAL, 463 (142491). [PMID:] [10.1016/j.cej.2023.142491] |
5. Chong Yu, Chi Li, Ying Zhang, Xiang Du, Jing-Han Wang, Zhan-You Chi, Qian Zhang. (2023) Effects of environment-relevant concentrations of antibiotics on seawater Chlorella sp. biofilm in artificial mariculture effluent. Algal Research-Biomass Biofuels and Bioproducts, 70 (103008). [PMID:] [10.1016/j.algal.2023.103008] |
6. Yu Wang, Yunxiang He, Qin Wang, Xiaoling Wang, Blaise L. Tardy, Joseph J. Richardson, Orlando J. Rojas, Junling Guo. (2023) Microporous membranes for ultrafast and energy-efficient removal of antibiotics through polyphenol-mediated nanointerfaces. Matter, 6 (260-273). [PMID:] [10.1016/j.matt.2022.09.021] |
7. Wan-Feng Xu, Yun Wang, Hai Huang, Jia-Wei Wu, Yuan Che, Chu-Jie Ding, Quan Zhang, Wei-Ling Cao, Li-Juan Cao. (2022) Octreotide-based therapies effectively protect mice from acute and chronic gastritis. EUROPEAN JOURNAL OF PHARMACOLOGY, 928 (174976). [PMID:35487253] [10.1016/j.ejphar.2022.174976] |
8. Ling Li, Yaoyao Du, Yang Wang, Ning He, Bing Wang, Tong Zhang. (2022) Atractylone Alleviates Ethanol-Induced Gastric Ulcer in Rat with Altered Gut Microbiota and Metabolites. Journal of Inflammation Research, [PMID:35996682] [10.2147/JIR.S372389] |
9. Shuting Zeng, Jing Sun, Ziwei Chen, Qiuxiang Xu, Wei Wei, Dongbo Wang, Bing-Jie Ni. (2021) The impact and fate of clarithromycin in anaerobic digestion of waste activated sludge for biogas production. ENVIRONMENTAL RESEARCH, 195 (110792). [PMID:33545126] [10.1016/j.envres.2021.110792] |
10. Xueqing Guo, Yang Liu, Wenjuan Dong, Qin Hu, Yong Li, Shaomin Shuang, Chuan Dong, Lishuai Cai, Xiaojuan Gong. (2021) Azithromycin detection in cells and tablets by N,S co-doped carbon quantum dots. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 252 (119506). [PMID:33561684] [10.1016/j.saa.2021.119506] |
11. Zhou Chen, Yanzeng Li, Yanyan Peng, Chengsong Ye, Shenghua Zhang. (2021) Effects of antibiotics on hydrolase activity and structure of microbial community during aerobic co-composting of food waste with sewage sludge. BIORESOURCE TECHNOLOGY, 321 (124506). [PMID:33310386] [10.1016/j.biortech.2020.124506] |
12. Yuanna Shen, Yiqing Zou, Xiaonan Chen, Pengyu Li, Yiqin Rao, Xuan Yang, Yingying Sun, Haiyan Hu. (2020) Antibacterial self-assembled nanodrugs composed of berberine derivatives and rhamnolipids against Helicobacter pylori. JOURNAL OF CONTROLLED RELEASE, 328 (575). [PMID:32946873] [10.1016/j.jconrel.2020.09.025] |
13. Ziming Zhao, Yanzhu Guo, Tao Zhang, Jiliang Ma, Haiming Li, Jinghui Zhou, Zhiwei Wang, Runcang Sun. (2020) Preparation of carbon dots from waste cellulose diacetate as a sensor for tetracycline detection and fluorescence ink. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 164 (4289). [PMID:32891644] [10.1016/j.ijbiomac.2020.08.243] |
14. Yunlei Zhou, Fei Li, Hanwen Wu, Yan Chen, Huanshun Yin, Shiyun Ai, Jun Wang. (2019) Electrochemical aptasensing strategy for kanamycin detection based on target-triggered single-strand DNA adsorption on MoS2 nanosheets and enzymatic signal amplification. SENSORS AND ACTUATORS B-CHEMICAL, 296 (126664). [PMID:] [10.1016/j.snb.2019.126664] |
15. Pengyu Li, Xiaonan Chen, Yuanna Shen, Huatian Li, Yiqing Zou, Gang Yuan, Ping Hu, Haiyan Hu. (2019) Mucus penetration enhanced lipid polymer nanoparticles improve the eradication rate of Helicobacter pylori biofilm. JOURNAL OF CONTROLLED RELEASE, 300 (52). [PMID:30825476] [10.1016/j.jconrel.2019.02.039] |