Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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C123300-1g | 1g | In stock | $337.90 | |
C123300-5g | 5g | In stock | $1,517.90 | |
C123300-25g | 25g | In stock | $6,829.90 |
Glucocorticoid, induces mono-oxygenase activity
Synonyms | CCI-4725 | Dermoxinale | NSC 758634 | CAS-25122-46-7 | Clobetasol 17-propionate | Clobetasol 17 Propionate | Clobetasol propionate, analytical standard | Clobetavix | NCGC00095078-01 | Olux (TN) | Pregna-1,4-diene-3,20-dione, 21-chloro-9-fluoro-11-hydroxy |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Glucocorticoid, induces monooxygenase activity in vivo . Alters the structure of tight junctions in epidermis. Smoothened hedgehog pathway receptor agonist. Anti-inflammatory, immunosuppressive and antimitotic agent. Active in vivo . |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Grade | Moligand™ |
Action Type | AGONIST |
Mechanism of action | Glucocorticoid receptor agonist |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
ALogP | 3.8 |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | [(8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate |
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INCHI | InChI=1S/C25H32ClFO5/c1-5-21(31)32-25(20(30)13-26)14(2)10-18-17-7-6-15-11-16(28)8-9-22(15,3)24(17,27)19(29)12-23(18,25)4/h8-9,11,14,17-19,29H,5-7,10,12-13H2,1-4H3/t14-,17-,18-,19-,22-,23-,24-,25-/m0/s1 |
InChi Key | CBGUOGMQLZIXBE-XGQKBEPLSA-N |
Canonical SMILES | CCC(=O)OC1(C(CC2C1(CC(C3(C2CCC4=CC(=O)C=CC43C)F)O)C)C)C(=O)CCl |
Isomeric SMILES | CCC(=O)O[C@@]1([C@H](C[C@@H]2[C@@]1(C[C@@H]([C@]3([C@H]2CCC4=CC(=O)C=C[C@@]43C)F)O)C)C)C(=O)CCl |
WGK Germany | 2 |
RTECS | TU3725000 |
PubChem CID | 32798 |
Molecular Weight | 466.97 |
DrugBank Ligand | DB01013 |
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PubChem CID | 32798 |
CAS Registry No. | 25122-46-7 |
ChEMBL Ligand | CHEMBL1159650 |
Wikipedia | Clobetasol propionate |
PEP | clobetasol propionate |
DrugCentral Ligand | 4452 |
RCSB PDB Ligand | XRD |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
G2425178 | Certificate of Analysis | Jun 17, 2024 | C123300 |
G2425179 | Certificate of Analysis | Jun 17, 2024 | C123300 |
B2301607 | Certificate of Analysis | Feb 07, 2023 | C123300 |
I1422047 | Certificate of Analysis | Jul 18, 2022 | C123300 |
C2219261 | Certificate of Analysis | Feb 28, 2022 | C123300 |
C2219403 | Certificate of Analysis | Feb 28, 2022 | C123300 |
D1402028 | Certificate of Analysis | Feb 19, 2022 | C123300 |
Solubility | 50mg/ml of chloroform |
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Sensitivity | heat sensitive |
Specific Rotation[α] | +99.0 °~ +103.0°(C=1,Dioxane) |
Melt Point(°C) | 196.0°C-200.0°C |
Pictogram(s) | GHS08, GHS07 |
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Signal | Danger |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H373:Causes damage to organs through prolonged or repeated exposure H413:May cause long lasting harmful effects to aquatic life H360:May damage fertility or the unborn child |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P318:if exposed or concerned, get medical advice. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 2 |
RTECS | TU3725000 |
1. Guozheng Zhao. (2023) Multi-Residue Detection of Eight Glucocorticoids by Nano-Au/Fluticasone Propionate Electrochemical Immunosensor. MOLECULES, 28 (18): (6619). [PMID:37764395] [10.3390/molecules28186619] |
2. Youfang Huang, Yanyun Li, Qing Luo, Xiaojia Huang. (2021) One-step preparation of functional groups-rich graphene oxide and carbon nanotubes nanocomposite for efficient magnetic solid phase extraction of glucocorticoids in environmental waters. CHEMICAL ENGINEERING JOURNAL, 406 (126785). [PMID:] [10.1016/j.cej.2020.126785] |
3. Guihua Gao, Sijia Li, Shuo Li, Yudan Wang, Pan Zhao, Xiangyu Zhang, Xiaohong Hou. (2018) A combination of computational−experimental study on metal-organic frameworks MIL-53(Al) as sorbent for simultaneous determination of estrogens and glucocorticoids in water and urine samples by dispersive micro-solid-phase extraction coupled to UPLC-MS/MS. TALANTA, 180 (358). [PMID:29332823] [10.1016/j.talanta.2017.12.071] |
1. Guozheng Zhao. (2023) Multi-Residue Detection of Eight Glucocorticoids by Nano-Au/Fluticasone Propionate Electrochemical Immunosensor. MOLECULES, 28 (18): (6619). [PMID:37764395] [10.3390/molecules28186619] |
2. Youfang Huang, Yanyun Li, Qing Luo, Xiaojia Huang. (2021) One-step preparation of functional groups-rich graphene oxide and carbon nanotubes nanocomposite for efficient magnetic solid phase extraction of glucocorticoids in environmental waters. CHEMICAL ENGINEERING JOURNAL, 406 (126785). [PMID:] [10.1016/j.cej.2020.126785] |
3. Guihua Gao, Sijia Li, Shuo Li, Yudan Wang, Pan Zhao, Xiangyu Zhang, Xiaohong Hou. (2018) A combination of computational−experimental study on metal-organic frameworks MIL-53(Al) as sorbent for simultaneous determination of estrogens and glucocorticoids in water and urine samples by dispersive micro-solid-phase extraction coupled to UPLC-MS/MS. TALANTA, 180 (358). [PMID:29332823] [10.1016/j.talanta.2017.12.071] |