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Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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SKU | Size | Availability | Price | Qty |
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C136686-100mg | 100mg | In stock | $78.90 | |
C136686-500mg | 500mg | In stock | $355.90 |
Selective Na + /2Cl - cotransporter inhibitor. Diuretic.
Synonyms | clopamide | 636-54-4 | Clopamidum | Brinaldix | Adurix | Aquex | Chlosudimeprimyl | Benzamide, 3-(aminosulfonyl)-4-chloro-N-(2,6-dimethyl-1-piperidinyl)-, cis- | MLS000028574 | 17S83WON0I | 4-Chloro-N-(2,6-dimethylpiperidino)-3-sulfamoylbenzamide | 4-Chloro-N-(cis-2,6-dimethyl |
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Specifications & Purity | ≥98% |
Biochemical and Physiological Mechanisms | Selective Na + /2Cl - cotransporter inhibitor. Diuretic activity in vivo . Orally active. |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Clopamide is shown to selectively inhibit the NCCT (sodium chloride cotransporter). After Hypokalemia was more marked with chronic administration to hypertension patients. Reported to considerably elevate the mean blood glucosein diabetic patients not receiving insulin. Also reported to lower body weight and blood pressure, and raise blood urea in diabetic patients. |
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IUPAC Name | 4-chloro-N-[(2R,6S)-2,6-dimethylpiperidin-1-yl]-3-sulfamoylbenzamide |
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INCHI | InChI=1S/C14H20ClN3O3S/c1-9-4-3-5-10(2)18(9)17-14(19)11-6-7-12(15)13(8-11)22(16,20)21/h6-10H,3-5H2,1-2H3,(H,17,19)(H2,16,20,21)/t9-,10+ |
InChi Key | LBXHRAWDUMTPSE-AOOOYVTPSA-N |
Canonical SMILES | CC1CCCC(N1NC(=O)C2=CC(=C(C=C2)Cl)S(=O)(=O)N)C |
Isomeric SMILES | C[C@@H]1CCC[C@@H](N1NC(=O)C2=CC(=C(C=C2)Cl)S(=O)(=O)N)C |
WGK Germany | 3 |
PubChem CID | 12492 |
Molecular Weight | 345.84 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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H2211052 | Certificate of Analysis | May 08, 2024 | C136686 |
H2211107 | Certificate of Analysis | May 08, 2024 | C136686 |
G2425182 | Certificate of Analysis | Apr 01, 2024 | C136686 |
Solubility | Soluble in DMSO (20 mg/mL), ethanol (5 mg/mL warm), and water (partly miscible). |
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Melt Point(°C) | 248-249℃ |
Pictogram(s) | GHS08, GHS07 |
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Signal | Danger |
Hazard Statements | H317:May cause an allergic skin reaction H334:May cause allergy or asthma symptoms or breathing difficulties if inhaled |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P501:Dispose of contents/container to ... P284:[In case of inadequate ventilation] Wear respiratory protection. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P342+P316:If experiencing respiratory symptoms: Get emergence medical help immediately. |
WGK Germany | 3 |