Clopamide - 98%, high purity , CAS No.636-54-4

  • ≥98%
Item Number
C136686
Grouped product items
SKUSizeAvailabilityPrice Qty
C136686-100mg
100mg
In stock
$78.90
C136686-500mg
500mg
In stock
$355.90

Selective Na + /2Cl - cotransporter inhibitor. Diuretic.

Basic Description

Synonymsclopamide | 636-54-4 | Clopamidum | Brinaldix | Adurix | Aquex | Chlosudimeprimyl | Benzamide, 3-(aminosulfonyl)-4-chloro-N-(2,6-dimethyl-1-piperidinyl)-, cis- | MLS000028574 | 17S83WON0I | 4-Chloro-N-(2,6-dimethylpiperidino)-3-sulfamoylbenzamide | 4-Chloro-N-(cis-2,6-dimethyl
Specifications & Purity≥98%
Biochemical and Physiological MechanismsSelective Na + /2Cl - cotransporter inhibitor. Diuretic activity in vivo . Orally active.
Storage TempStore at 2-8°C
Shipped InWet ice
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Clopamide is shown to selectively inhibit the NCCT (sodium chloride cotransporter). After Hypokalemia was more marked with chronic administration to hypertension patients. Reported to considerably elevate the mean blood glucosein diabetic patients not receiving insulin. Also reported to lower body weight and blood pressure, and raise blood urea in diabetic patients.
A compound that selectively inhibit the sodium chloride cotransporter.

Associated Targets(non-human)

Npy1r Neuropeptide Y receptor type 1 (8 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cckar Cholecystokinin A receptor (90 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pde4d Phosphodiesterase 4D (4 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name 4-chloro-N-[(2R,6S)-2,6-dimethylpiperidin-1-yl]-3-sulfamoylbenzamide
INCHI InChI=1S/C14H20ClN3O3S/c1-9-4-3-5-10(2)18(9)17-14(19)11-6-7-12(15)13(8-11)22(16,20)21/h6-10H,3-5H2,1-2H3,(H,17,19)(H2,16,20,21)/t9-,10+
InChi Key LBXHRAWDUMTPSE-AOOOYVTPSA-N
Canonical SMILES CC1CCCC(N1NC(=O)C2=CC(=C(C=C2)Cl)S(=O)(=O)N)C
Isomeric SMILES C[C@@H]1CCC[C@@H](N1NC(=O)C2=CC(=C(C=C2)Cl)S(=O)(=O)N)C
WGK Germany 3
PubChem CID 12492
Molecular Weight 345.84

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

3 results found

Lot NumberCertificate TypeDateItem
H2211052Certificate of AnalysisMay 08, 2024 C136686
H2211107Certificate of AnalysisMay 08, 2024 C136686
G2425182Certificate of AnalysisApr 01, 2024 C136686

Chemical and Physical Properties

SolubilitySoluble in DMSO (20 mg/mL), ethanol (5 mg/mL warm), and water (partly miscible).
Melt Point(°C)248-249℃

Safety and Hazards(GHS)

Pictogram(s) GHS08,   GHS07
Signal Danger
Hazard Statements

H317:May cause an allergic skin reaction

H334:May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P501:Dispose of contents/container to ...

P284:[In case of inadequate ventilation] Wear respiratory protection.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P272:Contaminated work clothing should not be allowed out of the workplace.

P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention.

P362+P364:Take off contaminated clothing and wash it before reuse.

P342+P316:If experiencing respiratory symptoms: Get emergence medical help immediately.

WGK Germany 3

Related Documents

Solution Calculators