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Home Bioactive Small Molecules Clothiapine - 99%, high purity , Serotonin 3 (5-HT3) receptor antagonist, CAS No.2058-52-8, Serotonin 3 (5-HT3) receptor antagonist
Clothiapine - 99%, high purity , Serotonin 3 (5-HT3) receptor antagonist, CAS No.2058-52-8, Serotonin 3 (5-HT3) receptor antagonist
a dibenzothiazepine analog of quetiapine
Basic Description Synonyms Clothiapine|Clotiapine|2058-52-8|Entumin|Etumine|HF 2159|Clothiapine [USAN]|S-805C|Clotiapine [INN]|DIBENZO(b,f)(1,4)THIAZEPINE, 2-CHLORO-11-(4-METHYL-1-PIPERAZINYL)-|HF-2159|LW 2159|8-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzothiazepine|Dibenzo[ Specifications & Purity ≥99% Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Action Type ANTAGONIST Mechanism of action Serotonin 3 (5-HT3) receptor antagonist Product Description Clothiapine is structurally analogous to quetiapine , clothiapine is of the dibenzothiazepine chemical class. Clothiapine is an internal standard for precise and accurate HPLC detection of hyroxyzine and buprenorphine from plasma.
Product Properties pKa pKa: 7.22 (Predicted) Ki Data Dopamine D2 receptor: Ki= 4.4 nM (rat); Serotonin 2b receptor: Ki= 0.6 nM (rat); Dopamine D1 receptor: Ki= 14 nM (rat); Muscarinic acetylcholine receptor: Ki= 136 nM (rat) ALogP 3.6
Names and Identifiers IUPAC Name 8-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzothiazepine INCHI InChI=1S/C18H18ClN3S/c1-21-8-10-22(11-9-21)18-14-12-13(19)6-7-16(14)23-17-5-3-2-4-15(17)20-18/h2-7,12H,8-11H2,1H3 InChi Key KAAZGXDPUNNEFN-UHFFFAOYSA-N Canonical SMILES CN1CCN(CC1)C2=NC3=CC=CC=C3SC4=C2C=C(C=C4)Cl Isomeric SMILES CN1CCN(CC1)C2=NC3=CC=CC=C3SC4=C2C=C(C=C4)Cl PubChem CID 16351 Molecular Weight 343.87
Chemical and Physical Properties Solubility Soluble in DMSO (10 mg/ml). Refractive Index n20D1.69 (Predicted) Boil Point(°C) 483.82° C at 760 mmHg (Predicted) Melt Point(°C) 118-120° C
Safety and Hazards(GHS) Pictogram(s) GHS06 , GHS09 , GHS07 Signal Danger Hazard Statements H301: Toxic if swallowed
H302: Harmful if swallowed
H400: Very toxic to aquatic life
H332: Harmful if inhaled
H410: Very toxic to aquatic life with long lasting effects
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P273: Avoid release to the environment.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P270: Do not eat, drink or smoke when using this product.
P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P391: Collect spillage.
P330: Rinse mouth.
P301+P316: IF SWALLOWED: Get emergency medical help immediately.
P301+P317: IF SWALLOWED: Get medical help.
P317: Get emergency medical help.
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