Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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C129965-5g | 5g | In stock | $13.90 | |
C129965-25g | 25g | In stock | $39.90 | |
C129965-100g | 100g | In stock | $89.90 | |
C129965-250g | 250g | In stock | $149.90 | |
C129965-500g | 500g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $200.90 |
Non-selective P450 cytochrome inhibitor
Synonyms | DTXSID7029871 | Mycelex | Canifug | Mycelex-7 Combination Pack | Mycelex (TN) | SVT-15652 | Diphenyl-(2-chlorophenyl)-1-imidazolylmethane | Desamix F | Lotrimin Cream | Mycelax | Mycelex OTC | Clotrimazol | clotrimazole | Gyne-Lotrimin 3 Combination Pack |
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Specifications & Purity | Moligand™, ≥98%(HPLC) |
Biochemical and Physiological Mechanisms | Clotrimazole is an imidazole derivative and an antifungal compound and a CYP (cytochrome P450) inhibitor. Clotrimazole has been shown to block the intermediate-conductance, IK1 channels (Ca2+ activated K+ channels), in cells such as erythrocytes. In vitro |
Shipped In | Normal |
Grade | Moligand™ |
Action Type | AGONIST, ANTAGONIST, CHANNEL BLOCKER, GATING INHIBITOR, INHIBITOR |
Mechanism of action | Cytochrome P450 51 inhibitor |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Clotrimazole is a synthetic, antifungal and broad-spectrum derivate of imidazole. |
ALogP | 5 |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Pubchem Sid | 488179725 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488179725 |
IUPAC Name | 1-[(2-chlorophenyl)-diphenylmethyl]imidazole |
INCHI | InChI=1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H |
InChi Key | VNFPBHJOKIVQEB-UHFFFAOYSA-N |
Canonical SMILES | C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3Cl)N4C=CN=C4 |
Isomeric SMILES | C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3Cl)N4C=CN=C4 |
WGK Germany | 3 |
RTECS | NI4377000 |
PubChem CID | 2812 |
Molecular Weight | 344.84 |
PubChem CID | 2812 |
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DrugBank Ligand | DB00257 |
CAS Registry No. | 23593-75-1 |
ChEBI | CHEBI:3764 |
ChEMBL Ligand | CHEMBL104 |
Wikipedia | Clotrimazole |
BindingDB Ligand | 31774 |
NURSA Ligand | 10.1621/7QJ4IXEBHR |
RCSB PDB Ligand | CL6 |
PEP | clotrimazole |
DrugCentral Ligand | 719 |
PubChem SID | 488179725 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
L2106320 | Certificate of Analysis | Jan 12, 2024 | C129965 |
K2323434 | Certificate of Analysis | Nov 06, 2023 | C129965 |
K2323435 | Certificate of Analysis | Nov 06, 2023 | C129965 |
K2323436 | Certificate of Analysis | Nov 06, 2023 | C129965 |
C2003059 | Certificate of Analysis | Oct 18, 2023 | C129965 |
K2126401 | Certificate of Analysis | Sep 20, 2023 | C129965 |
K2126402 | Certificate of Analysis | Sep 20, 2023 | C129965 |
K2126405 | Certificate of Analysis | Sep 20, 2023 | C129965 |
L2106248 | Certificate of Analysis | Sep 20, 2023 | C129965 |
L2106318 | Certificate of Analysis | Sep 20, 2023 | C129965 |
E1529071 | Certificate of Analysis | Dec 08, 2022 | C129965 |
J2307058 | Certificate of Analysis | Jan 24, 2022 | C129965 |
F23061274 | Certificate of Analysis | Nov 13, 2021 | C129965 |
F23061344 | Certificate of Analysis | Nov 13, 2021 | C129965 |
Solubility | Soluble in DMSO (25 mM), chloroform (50 mg/ml), DMF, ethyl acetate, ethanol, methanol, and acetone. |
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Melt Point(°C) | 141-149°C |
Pictogram(s) | GHS06, GHS08, GHS09, GHS07 |
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Signal | Danger |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H311:Toxic in contact with skin H373:Causes damage to organs through prolonged or repeated exposure H302:Harmful if swallowed H400:Very toxic to aquatic life H410:Very toxic to aquatic life with long lasting effects H361:Suspected of damaging fertility or the unborn child |
Precautionary Statements | P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P270:Do not eat, drink or smoke when using this product. P362+P364:Take off contaminated clothing and wash it before reuse. P391:Collect spillage. P330:Rinse mouth. P361+P364:Take off immediately all contaminated clothing and wash it before reuse. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P316:Get emergency medical help immediately. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
RTECS | NI4377000 |
Merck Index | 2417 |
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1. Guowei Li, Kai Lv, Xiangjun Pan, Siting Zhou, Hui Xing, Jun Xu, Dong Ma, Yunfeng Hu, Hao Xu. (2023) Dynamic nitric oxide/drug codelivery system based on polyrotaxane architecture for effective treatment of Candida albicans infection. Acta Biomaterialia, 155 (618). [PMID:36371005] [10.1016/j.actbio.2022.11.006] |
2. Xiaolei Wang, Hong Lu, Qiansheng Li, Yang Zhou, Jiti Zhou. (2022) Comparative genome and transcriptome of Rhodococcus pyridinivorans GF3 for analyzing the detoxification mechanism of anthraquinone compounds. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 237 (113545). [PMID:35453018] [10.1016/j.ecoenv.2022.113545] |
1. Guowei Li, Kai Lv, Xiangjun Pan, Siting Zhou, Hui Xing, Jun Xu, Dong Ma, Yunfeng Hu, Hao Xu. (2023) Dynamic nitric oxide/drug codelivery system based on polyrotaxane architecture for effective treatment of Candida albicans infection. Acta Biomaterialia, 155 (618). [PMID:36371005] [10.1016/j.actbio.2022.11.006] |
2. Xiaolei Wang, Hong Lu, Qiansheng Li, Yang Zhou, Jiti Zhou. (2022) Comparative genome and transcriptome of Rhodococcus pyridinivorans GF3 for analyzing the detoxification mechanism of anthraquinone compounds. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 237 (113545). [PMID:35453018] [10.1016/j.ecoenv.2022.113545] |