CM4620 , CAS No.C608608, Channel blocker of Orai1;Channel blocker of Orai2

Item Number

C608608

Grouped product items
SKU	Size	Availability	Price	Qty
C608608-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
C608608-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,001.90

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Basic Description

Synonyms	CM-4620\|1713240-67-5\|Zegocractin\|CM4620\|N-(5-(6-Chloro-2,2-difluorobenzo[d][1,3]dioxol-5-yl)pyrazin-2-yl)-2-fluoro-6-methylbenzamide\|Zegocractin [INN]\|CM 4620\|CHEMBL4753998\|564AW1RR37\|N-[5-(6-chloro-2,2-difluoro-1,3-benzodioxol-5-yl)pyrazin-2-yl]-2-fluoro
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	CHANNEL BLOCKER
Mechanism of action	Channel blocker of Orai1;Channel blocker of Orai2

Associated Targets

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	N-[5-(6-chloro-2,2-difluoro-1,3-benzodioxol-5-yl)pyrazin-2-yl]-2-fluoro-6-methylbenzamide
INCHI	InChI=1S/C19H11ClF3N3O3/c1-9-3-2-4-12(21)17(9)18(27)26-16-8-24-13(7-25-16)10-5-14-15(6-11(10)20)29-19(22,23)28-14/h2-8H,1H3,(H,25,26,27)
InChi Key	QQMKTHUGOQDEIL-UHFFFAOYSA-N
Canonical SMILES	Clc1cc2OC(Oc2cc1c1ncc(nc1)NC(=O)c1c(C)cccc1F)(F)F
Isomeric SMILES	CC1=C(C(=CC=C1)F)C(=O)NC2=NC=C(N=C2)C3=CC4=C(C=C3Cl)OC(O4)(F)F
PubChem CID	122507647

References

1. Gerasimenko JV, Gryshchenko O, Ferdek PE, Stapleton E, Hébert TO, Bychkova S, Peng S, Begg M, Gerasimenko OV, Petersen OH. (2013) Ca2+ release-activated Ca2+ channel blockade as a potential tool in antipancreatitis therapy.. Proc Natl Acad Sci USA, 110 (32): (13186-91). [PMID:23878235]
2. Gukovskaya AS, Pandol SJ, Gukovsky I. (2016) New insights into the pathways initiating and driving pancreatitis.. Curr Opin Gastroenterol, 32 (5): (429-435). [PMID:27428704]
3. Wen L, Voronina S, Javed MA, Awais M, Szatmary P, Latawiec D, Chvanov M, Collier D, Huang W, Barrett J et al.. (2015) Inhibitors of ORAI1 Prevent Cytosolic Calcium-Associated Injury of Human Pancreatic Acinar Cells and Acute Pancreatitis in 3 Mouse Models.. Gastroenterology, 149 (2): (481-92.e7). [PMID:25917787]

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Basic Description