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CNQX - ≥98%, high purity , CAS No.115066-14-3, Antagonist of GluA1;Antagonist of GluA2;GluA3;GluA4

  • Moligand™
  • ≥98%
Item Number
C131944
Grouped product items
SKUSizeAvailabilityPrice Qty
C131944-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$12.90
C131944-5mg
5mg
In stock
$48.90
C131944-25mg
25mg
In stock
$147.90
C131944-100mg
100mg
In stock
$375.90

AMPA / kainate antagonist

Basic Description

SynonymsCNQX|115066-14-3|6-CYANO-7-NITROQUINOXALINE-2,3-DIONE|7-Nitro-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-carbonitrile|7-nitro-2,3-dioxo-1,4-dihydroquinoxaline-6-carbonitrile|FG9065|FG 9065|6-Quinoxalinecarbonitrile, 1,2,3,4-tetrahydro-7-nitro-2,3-dioxo-|FG
Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological MechanismsPotent, competitive AMPA/kainate glutamate receptor antagonist.Potent, competitive AMPA / kainate receptor antagonist. Also antagonist at NMDA receptor glycine site.
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeANTAGONIST
Mechanism of actionAntagonist of GluA1;Antagonist of GluA2;GluA3;GluA4
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Associated Targets

CYP1A2 Tchem Cytochrome P450 1A2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CYP2D6 Tclin Cytochrome P450 2D6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CYP2C19 Tchem Cytochrome P450 2C19 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CYP2C9 Tchem Cytochrome P450 2C9 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ALOX15 Tchem Arachidonate 15-lipoxygenase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

MAPT Tclin Microtubule-associated protein tau 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GRIA4 Tclin Glutamate receptor 4 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GRIA2 Tclin Glutamate receptor 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GRIA3 Tclin Glutamate receptor 3 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GRIA1 Tclin Glutamate receptor 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

IMPA1 Tclin Inositol monophosphatase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 7-nitro-2,3-dioxo-1,4-dihydroquinoxaline-6-carbonitrile
INCHI InChI=1S/C9H4N4O4/c10-3-4-1-5-6(2-7(4)13(16)17)12-9(15)8(14)11-5/h1-2H,(H,11,14)(H,12,15)
InChi Key RPXVIAFEQBNEAX-UHFFFAOYSA-N
Canonical SMILES C1=C(C(=CC2=C1NC(=O)C(=O)N2)[N+](=O)[O-])C#N
Isomeric SMILES C1=C(C(=CC2=C1NC(=O)C(=O)N2)[N+](=O)[O-])C#N
WGK Germany 3
Alternate CAS 115066-14-3
PubChem CID 3721046
MeSH Entry Terms 1,4-dihydro-2,3-dihydroxy-7-nitro-6-quinoxalinecarbonitrile;6 Cyano 2,3 dihydroxy 7 nitroquinoxaline;6 Cyano 7 nitroquinoxaline 2,3 dione;6-Cyano-2,3-dihydroxy-7-nitroquinoxaline;6-Cyano-7-nitroquinoxaline-2,3-dione;CNQX;FG 9065;FG-9065;FG9065
Molecular Weight 232.15

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

4 results found

Lot NumberCertificate TypeDateItem
H1624071Certificate of AnalysisFeb 18, 2024 C131944
A2213363Certificate of AnalysisOct 20, 2023 C131944
A2213378Certificate of AnalysisOct 20, 2023 C131944
A2213380Certificate of AnalysisOct 20, 2023 C131944

Chemical and Physical Properties

Sensitivitylight sensitive

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H302:Harmful if swallowed

H312:Harmful in contact with skin

H332:Harmful if inhaled

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P270:Do not eat, drink or smoke when using this product.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P362+P364:Take off contaminated clothing and wash it before reuse.

P330:Rinse mouth.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P301+P317:IF SWALLOWED: Get medical help.

P317:Get emergency medical help.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

WGK Germany 3

Related Documents

References

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