CNQX - ≥98%, high purity , CAS No.115066-14-3, Antagonist of GluA1;Antagonist of GluA2;GluA3;GluA4

Item Number
C131944
Grouped product items
SKUSizeAvailabilityPrice Qty
C131944-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$12.90
C131944-5mg
5mg
In stock
$48.90
C131944-25mg
25mg
In stock
$147.90
C131944-100mg
100mg
In stock
$375.90

AMPA / kainate antagonist

Basic Description

Synonyms6-cyano-7-nitro-1,4-dihydroquinoxaline-2,3-dione | BRD-K53545112-304-01-6 | EX-A5681 | GTPL5475 | 6-CYANO-7-NITROQUINOXALINE-2,3-DIONE | [3H]CNQX | CNQX | CS-6970 | 6-Quinoxalinecarbonitrile,1,2,3,4-tetrahydro-7-nitro-2,3-dioxo- | Biomol-NT_000200 | BRD-K
Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological MechanismsPotent, competitive AMPA/kainate glutamate receptor antagonist.Potent, competitive AMPA / kainate receptor antagonist. Also antagonist at NMDA receptor glycine site.
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeANTAGONIST
Mechanism of actionAntagonist of GluA1;Antagonist of GluA2;GluA3;GluA4
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Associated Targets(Human)

GRIA4 Tclin Glutamate receptor 4 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GRIA2 Tclin Glutamate receptor 2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GRIA3 Tclin Glutamate receptor 3 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GRIA1 Tclin Glutamate receptor 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GBA1 Tclin Beta-glucocerebrosidase (14647 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ALOX15 Tchem Arachidonate 15-lipoxygenase (7108 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HepG2 (196354 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 (22556 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GRIA4 Tclin Glutamate receptor ionotropic AMPA (265 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
lef Anthrax lethal factor (7585 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mapt Microtubule-associated protein tau (6 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Impa1 Inositol monophosphatase 1 (16203 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name 7-nitro-2,3-dioxo-1,4-dihydroquinoxaline-6-carbonitrile
INCHI InChI=1S/C9H4N4O4/c10-3-4-1-5-6(2-7(4)13(16)17)12-9(15)8(14)11-5/h1-2H,(H,11,14)(H,12,15)
InChi Key RPXVIAFEQBNEAX-UHFFFAOYSA-N
Canonical SMILES C1=C(C(=CC2=C1NC(=O)C(=O)N2)[N+](=O)[O-])C#N
Isomeric SMILES C1=C(C(=CC2=C1NC(=O)C(=O)N2)[N+](=O)[O-])C#N
WGK Germany 3
Alternate CAS 115066-14-3
PubChem CID 3721046
MeSH Entry Terms 1,4-dihydro-2,3-dihydroxy-7-nitro-6-quinoxalinecarbonitrile;6 Cyano 2,3 dihydroxy 7 nitroquinoxaline;6 Cyano 7 nitroquinoxaline 2,3 dione;6-Cyano-2,3-dihydroxy-7-nitroquinoxaline;6-Cyano-7-nitroquinoxaline-2,3-dione;CNQX;FG 9065;FG-9065;FG9065
Molecular Weight 232.15

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

4 results found

Lot NumberCertificate TypeDateItem
H1624071Certificate of AnalysisFeb 18, 2024 C131944
A2213363Certificate of AnalysisOct 20, 2023 C131944
A2213378Certificate of AnalysisOct 20, 2023 C131944
A2213380Certificate of AnalysisOct 20, 2023 C131944

Chemical and Physical Properties

Sensitivitylight sensitive

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H302:Harmful if swallowed

H312:Harmful in contact with skin

H332:Harmful if inhaled

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P270:Do not eat, drink or smoke when using this product.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P362+P364:Take off contaminated clothing and wash it before reuse.

P330:Rinse mouth.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P301+P317:IF SWALLOWED: Get medical help.

P317:Get emergency medical help.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

WGK Germany 3

Related Documents

Citations of This Product

1. Huijun Li, Xin Xu, Jiwei Wang, Xuefeng Han, Zhouqing Xu.  (2021)  A Robust PVDF-Assisted Composite Membrane for Tetracycline Degradation in Emulsion and Oil-Water Separation.  Nanomaterials,  11  (12): (3201).  [PMID:34947550] [10.3390/nano11123201]
2. Shuling Shen, Junjie Wang, Zhujun Wu, Zheng Du, Zhihong Tang, Junhe Yang.  (2020)  Graphene Quantum Dots with High Yield and High Quality Synthesized from Low Cost Precursor of Aphanitic Graphite.  Nanomaterials,  10  (2): (375).  [PMID:32098041] [10.3390/nano10020375]
3. Zhicheng Wang, Shuping Nie, Ru Xia, Yang Lv, Ming Cao, Ming Chen, Qiannian Dong, Lifen Su, Peng Chen, Bin Yang, Jibin Miao, Zhengzhi Zheng, Jiasheng Qian.  (2018)  Preparation of the Yellow-Colored Aluminum Pigments with Double-Layer Structure Using a Crosslinked Copolymeric Dye.  Polymers,  10  (10): (1097).  [PMID:30961022] [10.3390/polym10101097]

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73. Shuling Shen, Junjie Wang, Zhujun Wu, Zheng Du, Zhihong Tang, Junhe Yang.  (2020)  Graphene Quantum Dots with High Yield and High Quality Synthesized from Low Cost Precursor of Aphanitic Graphite.  Nanomaterials,  10  (2): (375).  [PMID:32098041] [10.3390/nano10020375]
74. Zhicheng Wang, Shuping Nie, Ru Xia, Yang Lv, Ming Cao, Ming Chen, Qiannian Dong, Lifen Su, Peng Chen, Bin Yang, Jibin Miao, Zhengzhi Zheng, Jiasheng Qian.  (2018)  Preparation of the Yellow-Colored Aluminum Pigments with Double-Layer Structure Using a Crosslinked Copolymeric Dye.  Polymers,  10  (10): (1097).  [PMID:30961022] [10.3390/polym10101097]

Solution Calculators