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Cochlioquinone A - >99%, high purity , CAS No.32450-25-2

  • ≥99%
Item Number
C329499
Grouped product items
SKUSizeAvailabilityPrice Qty
C329499-500μg
500μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$276.90
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an antagonist of CKR-5 (CCR5)

Basic Description

SynonymsCochlioquinone A | CHEBI:177074 | Coclioquinone A | DTXSID501346549 | CochlioquinoneA | [(2S,3R,4S)-2-[(3R,4aR,6aR,12S,12aS,12bR)-12-hydroxy-3-(2-hydroxypropan-2-yl)-6a,12b-dimethyl-8,11-dioxo-1,2,3,4a,5,6,12,12a-octahydropyrano[3,2-a]xanthen-9-yl]-4-meth
Specifications & Purity≥99%
Storage TempStore at 2-8°C
Shipped InWet ice
Product Description

Cochlioquinone A is the major component of a bioactive pigment isolated from Bipolaris leersia. It has been found to be an antagonist of the human chemokine receptor CCR5 in human immunodeficiency virus type 1 (HIV-1). It is anti-angiogenic and exhibits inhibitory activity against diacylglycerol acyltransferase and NADH ubiquinone reductase.

Associated Targets(Human)

CYBA Tbio Cytochrome b-245 light chain (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
DGKA Tbio Diacylglycerol kinase alpha (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
MDA-MB-231 (73002 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NCI-H226 (44470 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Oryza sativa (2923 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYBA Cytochrome b-245 light chain (5 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Lolium multiflorum (260 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name [(2S,3R,4S)-2-[(3R,4aR,6aR,12S,12aS,12bR)-12-hydroxy-3-(2-hydroxypropan-2-yl)-6a,12b-dimethyl-8,11-dioxo-1,2,3,4a,5,6,12,12a-octahydropyrano[3,2-a]xanthen-9-yl]-4-methylhexan-3-yl] acetate
INCHI InChI=1S/C30H44O8/c1-9-15(2)25(36-17(4)31)16(3)18-14-19(32)22-24(34)27-29(7)12-10-20(28(5,6)35)37-21(29)11-13-30(27,8)38-26(22)23(18)33/h14-16,20-21,24-25,27,34-35H,9-13H2,1-8H3/t15-,16-,20+,21+,24+,25+,27+,29-,30+/m0/s1
InChi Key UWSYUCZPPVXEKW-MHUJPXPPSA-N
Canonical SMILES CCC(C)C(C(C)C1=CC(=O)C2=C(C1=O)OC3(CCC4C(C3C2O)(CCC(O4)C(C)(C)O)C)C)OC(=O)C
Isomeric SMILES CC[C@H](C)[C@H]([C@@H](C)C1=CC(=O)C2=C(C1=O)O[C@@]3(CC[C@@H]4[C@@]([C@H]3[C@@H]2O)(CC[C@@H](O4)C(C)(C)O)C)C)OC(=O)C
PubChem CID 161747
Molecular Weight 532.67

Certificates

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Chemical and Physical Properties

SolubilitySoluble in ethanol, methanol, DMF or DMSO.

Related Documents

 SDS

 Specification Sheet

Solution Calculators

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