Skip to the beginning of the images gallery

Coenzyme Q0 - 97%, high purity , CAS No.605-94-7

≥97%

CAS#: 605-94-7
Formula: C₉H₁₀O₄
Molecular Weight: 182.17
Beilstein Registry Number: 1640422
EC Number: 210-100-8
MDL number: MFCD00001595
PubChem CID: 69068

Item Number

C106269

Grouped product items
SKU	Size	Availability	Price
C106269-1g	1g	In stock	$38.90
C106269-5g	5g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$114.90
C106269-10g	10g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$205.90
C106269-25g	25g	In stock	$461.90

Basic Description

Synonyms	2,3-Dimethoxy 5-methyl-1,4-benzoquinone \| EINECS 210-100-8 \| Q0 \| FT-0609676 \| Ubiquinone 0 \| Ubiquinone Qo \| ubiquinone-Q0 \| 2,3 dimethoxy 5-methyl 1,4 benzoquinone \| 2,3-Dimethoxy-5-methyl-p-benzoquinone \| 2,3-Dimethoxy-5-methylbenzo-1,4-quinone \| InChI
Specifications & Purity	≥97%
Storage Temp	Store at 2-8°C,Protected from light
Shipped In	Wet ice

Associated Targets(non-human)

Trichoplusia ni (986 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	2,3-dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione
INCHI	InChI=1S/C9H10O4/c1-5-4-6(10)8(12-2)9(13-3)7(5)11/h4H,1-3H3
InChi Key	UIXPTCZPFCVOQF-UHFFFAOYSA-N
Canonical SMILES	CC1=CC(=O)C(=C(C1=O)OC)OC
Isomeric SMILES	CC1=CC(=O)C(=C(C1=O)OC)OC
WGK Germany	2
PubChem CID	69068
Molecular Weight	182.17
Beilstein	1640422
Reaxy-Rn	1640422

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot Number	Certificate Type	Date	Item
E2009021	Certificate of Analysis	Feb 18, 2024	C106269
H1514044	Certificate of Analysis	Apr 12, 2023	C106269

Chemical and Physical Properties

Sensitivity	Light sensitive.
Melt Point(°C)	58-60°C

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	2
Reaxy-Rn	1640422

References

1. J J Poderoso,M C Carreras,F Schöpfer,C L Lisdero,N A Riobó,C Giulivi,A D Boveris,A Boveris,E Cadenas. (1999-05-08) The reaction of nitric oxide with ubiquinol: kinetic properties and biological significance.. Free radical biology & medicine, 26 ((7-8)): (925-935). [PMID:10232836]
2. R C Lawson,A Ferrer,W Flores,A E Alegría. (1999-09-22) Sonochemistry of quinones in argon-saturated aqueous solutions: enhanced cytochrome c reduction.. Chemical research in toxicology, 12 ((9)): (850-854). [PMID:10490507]
3. S Martinucci,I Szabò,F Tombola,M Zoratti. (2000-10-18) Ca2+-reversible inhibition of the mitochondrial megachannel by ubiquinone analogues.. FEBS letters, 480 ((2-3)): (89-94). [PMID:11034306]
4. Andreas Bock,Roy Gross. (2002-07-24) The unorthodox histidine kinases BvgS and EvgS are responsive to the oxidation status of a quinone electron carrier.. European journal of biochemistry, 269 ((14)): (3479-3484). [PMID:12135487]
5. Jason W Cooley,Arthur G Roberts,Michael K Bowman,David M Kramer,Fevzi Daldal. (2004-02-26) The raised midpoint potential of the [2Fe2S] cluster of cytochrome bc1 is mediated by both the Qo site occupants and the head domain position of the Fe-S protein subunit.. Biochemistry, 43 ((8)): (2217-2227). [PMID:14979718]
6. Ismael Santa-María,Félix Hernández,Concepción Pérez Martín,Jesús Avila,Francisco J Moreno. (2004-03-10) Quinones facilitate the self-assembly of the phosphorylated tubulin binding region of tau into fibrillar polymers.. Biochemistry, 43 ((10)): (2888-2897). [PMID:15005624]
7. Petr Galuszka,Jitka Frébortová,Tomás Werner,Mamoru Yamada,Miroslav Strnad,Thomas Schmülling,Ivo Frébort. (2004-10-14) Cytokinin oxidase/dehydrogenase genes in barley and wheat: cloning and heterologous expression.. European journal of biochemistry, 271 ((20)): (3990-4002). [PMID:15479228]
8. Emy Basso,Lisa Fante,Jonathan Fowlkes,Valeria Petronilli,Michael A Forte,Paolo Bernardi. (2005-03-29) Properties of the permeability transition pore in mitochondria devoid of Cyclophilin D.. The Journal of biological chemistry, 280 ((19)): (18558-18561). [PMID:15792954]
9. Wen-Wu Li,Jürgen Heinze,Wolfgang Haehnel. (2005-04-28) Site-specific binding of quinones to proteins through thiol addition and addition-elimination reactions.. Journal of the American Chemical Society, 127 ((17)): (6140-6141). [PMID:15853297]
10. Yung-Fu Wang,Sheng-Shung Cheng,Seiya Tsujimura,Tokuji Ikeda,Kenji Kano. (2006-01-25) Escherichia coli-catalyzed bioelectrochemical oxidation of acetate in the presence of mediators.. Bioelectrochemistry (Amsterdam, Netherlands), 69 ((1)): (74-81). [PMID:16431164]
11. O I Shadyro,R M Kisel,V V Vysotskii,I P Edimecheva. (2006-07-18) Effects of vitamins, coenzymes and amino acids on reactions of homolytic cleavage of the O-glycoside bond in carbohydrates.. Bioorganic & medicinal chemistry letters, 16 ((18)): (4763-4766). [PMID:16844374]
12. Umberto De Marchi,Emy Basso,Ildikò Szabò,Mario Zoratti. (2006-11-28) Electrophysiological characterization of the Cyclophilin D-deleted mitochondrial permeability transition pore.. Molecular membrane biology, 23 ((6)): (521-530). [PMID:17127624]
13. Tiffany J Somers-Edgar, Rhonda J Rosengren,. (2008-10-03) Coenzyme Q0 induces apoptosis and modulates the cell cycle in estrogen receptor negative breast cancer cells.. Anti-cancer drugs, 20 ((1)): ( 33-40 ). [PMID:18830129]
14. Zhichao Pei,Tobias Gustavsson,Robert Roth,Torbjörn Frejd,Cecilia Hägerhäll. (2010-04-23) Photolabile ubiquinone analogues for identification and characterization of quinone binding sites in proteins.. Bioorganic & medicinal chemistry, 18 ((10)): (3457-3466). [PMID:20409720]
15. Flavien Devun,Ludivine Walter,Julie Belliere,Cécile Cottet-Rousselle,Xavier Leverve,Eric Fontaine. (2010-07-30) Ubiquinone analogs: a mitochondrial permeability transition pore-dependent pathway to selective cell death.. PloS one, 5 ((7)): (e11792-e11792). [PMID:20668684]
16. Ming-Der Wu,Ming-Jen Cheng,Wei-Yi Wang,Hui-Chun Huang,Gwo-Fang Yuan,Jih-Jung Chen,Ih-Sheng Chen,Bor-Cheh Wang. (2011-02-22) Antioxidant activities of extracts and metabolites isolated from the fungus Antrodia cinnamomea.. Natural product research, 25 ((16)): (1488-1496). [PMID:21337253]
17. Sophia von Stockum,Emy Basso,Valeria Petronilli,Patrizia Sabatelli,Michael A Forte,Paolo Bernardi. (2011-10-11) Properties of Ca(2+) transport in mitochondria of Drosophila melanogaster.. The Journal of biological chemistry, 286 ((48)): (41163-41170). [PMID:21984833]
18. Julie Belliere,Flavien Devun,Cécile Cottet-Rousselle,Cécile Batandier,Xavier Leverve,Eric Fontaine. (2012-01-17) Prerequisites for ubiquinone analogs to prevent mitochondrial permeability transition-induced cell death.. Journal of bioenergetics and biomembranes, 44 ((1)): (207-212). [PMID:22246424]
19. Tianyong Zheng,Daniel G Olson,Liang Tian,Yannick J Bomble,Michael E Himmel,Jonathan Lo,Shuen Hon,A Joe Shaw,Johannes P van Dijken,Lee R Lynd. (2015-05-28) Cofactor Specificity of the Bifunctional Alcohol and Aldehyde Dehydrogenase (AdhE) in Wild-Type and Mutant Clostridium thermocellum and Thermoanaerobacterium saccharolyticum.. Journal of bacteriology, 197 ((15)): (2610-2619). [PMID:26013492]
20. Hui-Min Wang,Hsin-Ling Yang,Varadharajan Thiyagarajan,Tzu-Hsiang Huang,Pei-Jane Huang,Ssu-Ching Chen,Jer-Yuh Liu,Li-Sung Hsu,Hsueh-Wei Chang,You-Cheng Hseu. (2016-11-09) Coenzyme Q. Integrative cancer therapies, 16 ((3)): (385-396). [PMID:27821721]
21. N G Krylova,T A Kulahava,V T Cheschevik,I K Dremza,G N Semenkova,I B Zavodnik. (2017-02-24) Redox regulation of mitochondrial functional activity by quinones.. Physiology international, 103 ((4)): (439-458). [PMID:28229632]
22. Rajib Paul,Anupom Borah. (2017-12-22) Global loss of acetylcholinesterase activity with mitochondrial complexes inhibition and inflammation in brain of hypercholesterolemic mice.. Scientific reports, 7 ((1)): (17922-17922). [PMID:29263397]
23. Juntai Liu,Vincent M Friebe,David J K Swainsbury,Lucy I Crouch,David A Szabo,Raoul N Frese,Michael R Jones. (2018-01-25) Engineered photoproteins that give rise to photosynthetically-incompetent bacteria are effective as photovoltaic materials for biohybrid photoelectrochemical cells.. Faraday discussions, 207 ((0)): (307-327). [PMID:29364305]
24. Stanislaw Schmidt,Ralf Schubert,Lars Tramsen,Thomas Lehrnbecher. (2018-11-21) Impact of Antifungal Compounds on Viability and Anti-Aspergillus Activity of Human Natural Killer Cells.. Antimicrobial agents and chemotherapy, 63 ((2)): [PMID:30455240]
25. Stanislaw Schmidt,Michael Hogardt,Asuman Demir,Frauke Röger,Thomas Lehrnbecher. (2019-12-05) Immunosuppressive Compounds Affect the Fungal Growth and Viability of Defined Aspergillus Species.. Pathogens (Basel, Switzerland), 8 ((4)): [PMID:31795350]
26. Sarah Nicolai,Marcin Wegrecki,Tan-Yun Cheng,Elvire A Bourgeois,Rachel N Cotton,Jacob A Mayfield,Gwennaëlle C Monnot,Jérôme Le Nours,Ildiko Van Rhijn,Jamie Rossjohn,D Branch Moody,Annemieke de Jong. (2020-01-05) Human T cell response to CD1a and contact dermatitis allergens in botanical extracts and commercial skin care products.. Science immunology, 5 ((43)): [PMID:31901073]
27. Gergana Popova,Marcus J G W Ladds,Lars Johansson,Aljona Saleh,Johanna Larsson,Lars Sandberg,Sara Häggblad Sahlberg,Weixing Qian,Hjalmar Gullberg,Neeraj Garg,Anna-Lena Gustavsson,Martin Haraldsson,David Lane,Ulrika Yngve,Sonia Lain. (2020-03-28) Optimization of Tetrahydroindazoles as Inhibitors of Human Dihydroorotate Dehydrogenase and Evaluation of Their Activity and In Vitro Metabolic Stability.. Journal of medicinal chemistry, 63 ((8)): (3915-3934). [PMID:32212728]
28. Stefania Fiorcari,Rossana Maffei,Daniela Vallerini,Lydia Scarfò,Patrizia Barozzi,Monica Maccaferri,Leonardo Potenza,Paolo Ghia,Mario Luppi,Roberto Marasca. (2020-09-29) BTK Inhibition Impairs the Innate Response Against Fungal Infection in Patients With Chronic Lymphocytic Leukemia.. Frontiers in immunology, 11 (2158-2158). [PMID:32983178]
29. Sun-Yong Kim,Tomoyuki Mori,Min Fey Chek,Shunji Furuya,Ken Matsumoto,Taisei Yajima,Toshihiko Ogura,Toshio Hakoshima. (2021-01-24) Structural insights into vesicle amine transport-1 (VAT-1) as a member of the NADPH-dependent quinone oxidoreductase family.. Scientific reports, 11 ((1)): (2120-2120). [PMID:33483563]
30. V A Roginsky,G Bruchelt,O Bartuli. (1997-12-31) Ubiquinone-0 (2,3-dimethoxy-5-methyl-1,4-benzoquinone) as effective catalyzer of ascorbate and epinephrine oxidation and damager of neuroblastoma cells.. Biochemical pharmacology, 55 ((1)): (85-91). [PMID:9413934]
31. V E Kagan,A Arroyo,V A Tyurin,Y Y Tyurina,J M Villalba,P Navas. (1998-06-30) Plasma membrane NADH-coenzyme Q0 reductase generates semiquinone radicals and recycles vitamin E homologue in a superoxide-dependent reaction.. FEBS letters, 428 ((1-2)): (43-46). [PMID:9645471]
32. B K Rao,A M Tyryshkin,A G Roberts,M K Bowman,D M Kramer. (2000-03-22) Inhibitory copper binding site on the spinach cytochrome b6f complex: implications for Qo site catalysis.. Biochemistry, 39 ((12)): (3285-3296). [PMID:10727220]
33. K S Echtay,E Winkler,K Frischmuth,M Klingenberg. (2001-02-15) Uncoupling proteins 2 and 3 are highly active H(+) transporters and highly nucleotide sensitive when activated by coenzyme Q (ubiquinone).. Proceedings of the National Academy of Sciences of the United States of America, 98 ((4)): (1416-1421). [PMID:11171965]
34. Qiong Guo,Jean T Corbett,Guihua Yue,Yang C Fann,Steven Y Qian,Kenneth B Tomer,Ronald P Mason. (2001-12-19) Electron spin resonance investigation of semiquinone radicals formed from the reaction of ubiquinone 0 with human oxyhemoglobin.. The Journal of biological chemistry, 277 ((8)): (6104-6110). [PMID:11748217]
35. Michael J MacDonald,Rhonda D Husain,Susanne Hoffmann-Benning,Tracie R Baker. (2004-04-13) Immunochemical identification of coenzyme Q0-dihydrolipoamide adducts in the E2 components of the alpha-ketoglutarate and pyruvate dehydrogenase complexes partially explains the cellular toxicity of coenzyme Q0.. The Journal of biological chemistry, 279 ((26)): (27278-27285). [PMID:15075342]
36. László Gerencsér,Péter Maróti. (2008-03-28) Turnover of ubiquinone-0 at the acceptor side of photosynthetic reaction center.. European biophysics journal : EBJ, 37 ((7)): (1195-1205). [PMID:18368404]
37. Anna W C Leung,Pinadda Varanyuwatana,Andrew P Halestrap. (2008-08-01) The mitochondrial phosphate carrier interacts with cyclophilin D and may play a key role in the permeability transition.. The Journal of biological chemistry, 283 ((39)): (26312-26323). [PMID:18667415]
38. Wei Yuan,James L Edwards. (2011-03-23) Thiol metabolomics of endothelial cells using capillary liquid chromatography mass spectrometry with isotope coded affinity tags.. Journal of chromatography. A, 1218 ((18)): (2561-2568). [PMID:21420094]
39. Krzysztof Dwiecki,Grażyna Neunert,Małgorzata Nogala-Kałucka,Krzysztof Polewski. (2015-05-16) Fluorescence quenching studies on the interaction of catechin-quinone with CdTe quantum dots. Mechanism elucidation and feasibility studies.. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 149 (523-530). [PMID:25978020]
40. Laure-Estelle Cassagnes,Monivan Chhour,Pierre Pério,Jan Sudor,Régis Gayon,Gilles Ferry,Jean A Boutin,Françoise Nepveu,Karine Reybier. (2018-03-13) Oxidative stress and neurodegeneration: The possible contribution of quinone reductase 2.. Free radical biology & medicine, 120 (56-61). [PMID:29526807]
41. Lydia Kasper,Annika König,Paul-Albert Koenig,Mark S Gresnigt,Johannes Westman,Rebecca A Drummond,Michail S Lionakis,Olaf Groß,Jürgen Ruland,Julian R Naglik,Bernhard Hube. (2018-10-17) The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes.. Nature communications, 9 ((1)): (4260-4260). [PMID:30323213]
42. Takumi Satoh,Mitsunori Todoroki,Kazuya Kobayashi,Youichi Niimura,Shinji Kawasaki. (2019-03-19) Purified thioredoxin reductase from O2-sensitive Bifidobacterium bifidum degrades H2O2 by interacting with alkyl hydroperoxide reductase.. Anaerobe, 57 (45-54). [PMID:30880149]
43. Marco Zuccolo,Andrea Kunova,Loana Musso,Fabio Forlani,Andrea Pinto,Giulio Vistoli,Silvia Gervasoni,Paolo Cortesi,Sabrina Dallavalle. (2019-08-08) Dual-active antifungal agents containing strobilurin and SDHI-based pharmacophores.. Scientific reports, 9 ((1)): (11377-11377). [PMID:31388065]
44. Stanislaw Schmidt,Ralf Schubert,Asuman Demir,Thomas Lehrnbecher. (2019-11-23) Distinct Effects of Immunosuppressive Drugs on the Anti-Aspergillus Activity of Human Natural Killer Cells.. Pathogens (Basel, Switzerland), 8 ((4)): [PMID:31752374]
45. Nikita Paul,Lakshmi Suresh,Jayraj V Vaghasiya,Lin Yang,Yaoxin Zhang,Dilip Krishna Nandakumar,Michael R Jones,Swee Ching Tan. (2020-07-31) Self-powered all weather sensory systems powered by Rhodobacter sphaeroides protein solar cells.. Biosensors & bioelectronics, 165 (112423-112423). [PMID:32729541]
46. Peng Fei,Hongxia Feng,Yanyan Wang,Huaibin Kang,Min Xing,Yunhe Chang,Ling Guo,Junliang Chen. (2020-08-31) Amaranthus tricolor crude extract inhibits Cronobacter sakazakii isolated from powdered infant formula.. Journal of dairy science, 103 ((11)): (9969-9979). [PMID:32861498]
47. Stanislaw Schmidt,Marie Luckowitsch,Michael Hogardt,Thomas Lehrnbecher. (2021-03-07) Natural Killer Cell Line NK-92-Mediated Damage of Medically Important Fungi.. Journal of fungi (Basel, Switzerland), 7 ((2)): [PMID:33671240]

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Dilution Calculator

Determine the dilution needed to prepare a stock solution.