Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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C106738-100mg | 100mg | In stock | $13.90 | |
C106738-200mg | 200mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $31.90 | |
C106738-500mg | 500mg | In stock | $65.90 | |
C106738-1g | 1g | In stock | $90.90 | |
C106738-5g | 5g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $314.90 | |
C106738-25g | 25g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $1,259.90 |
Inhibitor of microtubule formation
Synonyms | Colchicin | Condylon | Kolkicin | 7-alpha-H-Colchicine | 7alphaH-Colchicine | spindle poison | CCRIS 691 | Mitigare | Colchisol | (-)-colchicine | Colchysat | Colcrys | Colsaloid | (S)-colchicine | Colchineos | Goutnil | Colchicinum | Colcin | NSC 757 | C |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Colchicine is an inhibitor of microtubule polymerization which blocks chromosome segregation during meiosis. Consequently, Colchicine is used to induce polyploidy (tetraploid) in plant cells.Inhibitor of microtubule formation (K i = 2.1 μM). Antimitotic, |
Storage Temp | Argon charged |
Shipped In | Normal |
Grade | Moligand™ |
Action Type | AGONIST, ANTAGONIST, INHIBITOR |
Mechanism of action | Inhibitor of bromodomain containing 4;Antagonist of glycine receptor α1 subunit;Antagonist of glycine receptor α2 subunit;Agonist of TAS2R46;Agonist of TAS2R4;Inhibitor of tubulin beta class I |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Product Description |
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IUPAC Name | N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide |
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INCHI | InChI=1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1 |
InChi Key | IAKHMKGGTNLKSZ-INIZCTEOSA-N |
Canonical SMILES | CC(=O)NC1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC |
Isomeric SMILES | CC(=O)N[C@H]1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC |
WGK Germany | 3 |
RTECS | GH0700000 |
PubChem CID | 6167 |
UN Number | 1544 |
Packing Group | I |
Molecular Weight | 399.44 |
Beilstein | 2228813 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
H2427343 | Certificate of Analysis | Sep 03, 2024 | C106738 |
H2427362 | Certificate of Analysis | Sep 03, 2024 | C106738 |
H2406342 | Certificate of Analysis | Jul 12, 2024 | C106738 |
H2406343 | Certificate of Analysis | Jul 12, 2024 | C106738 |
H2406344 | Certificate of Analysis | Jul 12, 2024 | C106738 |
H2406345 | Certificate of Analysis | Jul 12, 2024 | C106738 |
D2407073 | Certificate of Analysis | Oct 21, 2023 | C106738 |
K2303170 | Certificate of Analysis | Oct 21, 2023 | C106738 |
K2303167 | Certificate of Analysis | Oct 21, 2023 | C106738 |
K2303166 | Certificate of Analysis | Oct 21, 2023 | C106738 |
K2303164 | Certificate of Analysis | Oct 21, 2023 | C106738 |
K2303163 | Certificate of Analysis | Oct 21, 2023 | C106738 |
E23181032 | Certificate of Analysis | May 31, 2023 | C106738 |
D2314929 | Certificate of Analysis | May 06, 2023 | C106738 |
J2228424 | Certificate of Analysis | Aug 01, 2022 | C106738 |
J2228425 | Certificate of Analysis | Aug 01, 2022 | C106738 |
J2228426 | Certificate of Analysis | Aug 01, 2022 | C106738 |
J2228427 | Certificate of Analysis | Aug 01, 2022 | C106738 |
J2228422 | Certificate of Analysis | Aug 01, 2022 | C106738 |
I2321012 | Certificate of Analysis | Aug 01, 2022 | C106738 |
I2321008 | Certificate of Analysis | Aug 01, 2022 | C106738 |
Solubility | Soluble in water and alcohol. Sparingly soluble in ether. |
---|---|
Sensitivity | Light sensitive,Hygroscopic |
Specific Rotation[α] | -238° (C=1,EtOH) |
Melt Point(°C) | 150-160°C |
Pictogram(s) | GHS06, GHS08 |
---|---|
Signal | Danger |
Hazard Statements | H300:Fatal if swallowed H340:May cause genetic defects |
Precautionary Statements | P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P281:Use personal protective equipment as required. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P318:if exposed or concerned, get medical advice. |
WGK Germany | 3 |
RTECS | GH0700000 |
Class | 6.1 |
Merck Index | 2471 |
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1. Yunbo Yan, Linqian Yu, Binyang Chen, Chang’an Cao, Hairong Zhao, Qiang Wang, De Xie, Yuemei Xi, Chenggui Zhang, Jidong Cheng. (2023) Mastoparan M Suppressed NLRP3 Inflammasome Activation by Inhibiting MAPK/NF-κB and Oxidative Stress in Gouty Arthritis. Journal of Inflammation Research, [PMID:38116368] |
2. Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia. (2024) Lipid-like gemcitabine diester-loaded liposomes for improved chemotherapy of pancreatic cancer. JOURNAL OF CONTROLLED RELEASE, 365 (1): (112). [PMID:37981050] |
3. Fang Ruiyue, Zhao Ying, Lin Shiyuan, Wei Yue, Chen Hui. (2023) Promoting oral absorption of Panax notoginseng saponins via thiolated trimethyl chitosan and wheat germ agglutinin–modified nanoformulation. Drug Delivery and Translational Research, (1-16). [PMID:37787882] |
4. Yajing Wang, Ziwei Ding, Shiqun Lv, Jie Liu, Jie Pan, Yingcong Yu, Jun Gao, Xianfeng Huang. (2023) Development of tLyP-1 functionalized nanoliposomes with tunable internal water phase for glioma targeting. JOURNAL OF LIPOSOME RESEARCH, [PMID:36974836] |
5. Liping Zhang, Yuan Xu, Wenjuan Cao, Shibao Xie, Lu Wen, Gang Chen. (2023) Understanding the translocation mechanism of PLGA nanoparticles across round window membrane into the inner ear: a guideline for inner ear drug delivery based on nanomedicine. International Journal of Nanomedicine, [PMID:29403277] |
6. Zhang Lin, Dong Yi, Lu Yunhao, Mo Rui, He Qiang. (2023) Photolysis and cytotoxicity of the potentially toxic composition of daylily flower: colchicine. Journal of Food Measurement and Characterization, 17 (3): (2978-2987). [PMID:] |
7. Zhong Wenzhao, Guo Feng, Chen Fangman, Law Man-Kay, Lu Jun, Shao Dan, Yu Hua, Chan Ging, Chen Meiwan. (2022) A multifunctional oxidative stress nanoamplifier with ROS amplification and GSH exhaustion for enhanced chemodynamic therapy. Frontiers in Pharmacology, 13 [PMID:36438812] |
8. Yuhan Yang, Yangyi Chen, Dianpeng Li, Shiyuan Lin, Hui Chen, Wei Wu, Wei Zhang. (2023) Linolenic acid conjugated chitosan micelles for improving the oral absorption of doxorubicin via fatty acid transporter. CARBOHYDRATE POLYMERS, 300 (120233). [PMID:36372473] |
9. Baogui Xu, Jiawen Zheng, Xiaoxiao Tian, Falei Yuan, zhongliang Liu, Yafeng Zhou, Zuisu Yang, Xianjun Ding. (2022) Protective mechanism of traditional Chinese medicine guizhi fuling pills against carbon tetrachloride-induced kidney damage is through inhibiting oxidative stress, inflammation and regulating the intestinal flora. PHYTOMEDICINE, 101 (154129). [PMID:35490491] |
10. Fenglei Zhang, Xuejing Pei, Xiaoxia Peng, Dongxia Gou, Xiao Fan, Xuefei Zheng, Chengcheng Song, Yifa Zhou, Sisi Cui. (2022) Dual crosslinking of folic acid-modified pectin nanoparticles for enhanced oral insulin delivery. Biomaterials Advances, 135 (212746). [PMID:35929218] |
11. Jihui Zhang, Hongwei Lei, Xiu Li. (2022) The protective effects of S14G-humanin (HNG) against mono-sodium urate (MSU) crystals- induced gouty arthritis. Bioengineered, 13 (1): (345-356). [PMID:34965184] |
12. Yang Zhong, Jiayu Gu, Yaoquan Su, Lingzhi Zhao, Yunyun Zhou, Juanjuan Peng. (2022) Real-time screening of hepatotoxins in natural medicine by peroxynitrite responsive lanthanide-based NIR-II luminescent probes. CHEMICAL ENGINEERING JOURNAL, 433 (133263). [PMID:] |
13. Qing Wang,Jie Chen,Kun Huang,Xin Zhang,Li Xu,Zhi-guo Shi. (2014-12-07) Preparation, characterization and application of N-methylene phosphonic acid chitosan grafted magnesia-zirconia stationary phase.. Analytica chimica acta, 854 (191-201). [PMID:25479884] |
14. Qing Wang,Mao Ye,Li Xu,Zhi-guo Shi. (2015-09-01) A reversed-phase/hydrophilic interaction mixed-mode C18-Diol stationary phase for multiple applications.. Analytica chimica acta, 888 (182-190). [PMID:26320974] |
1. Pinto AP et al.. (2022) IL-6 deletion decreased REV-ERBα protein and influenced autophagy and mitochondrial markers in the skeletal muscle after acute exercise.. Front Immunol, 13 (953272). [PMID:36311768] |
2. Pinto AP et al.. (2021) Impact of Different Physical Exercises on the Expression of Autophagy Markers in Mice.. Int J Mol Sci, 22 (5): [PMID:33807902] |
3. da Rocha AL et al.. (2020) Moderate, but Not Excessive, Training Attenuates Autophagy Machinery in Metabolic Tissues.. Int J Mol Sci, 21 (22): [PMID:33182536] |
4. Yunbo Yan, Linqian Yu, Binyang Chen, Chang’an Cao, Hairong Zhao, Qiang Wang, De Xie, Yuemei Xi, Chenggui Zhang, Jidong Cheng. (2023) Mastoparan M Suppressed NLRP3 Inflammasome Activation by Inhibiting MAPK/NF-κB and Oxidative Stress in Gouty Arthritis. Journal of Inflammation Research, [PMID:38116368] |
5. Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia. (2024) Lipid-like gemcitabine diester-loaded liposomes for improved chemotherapy of pancreatic cancer. JOURNAL OF CONTROLLED RELEASE, 365 (1): (112). [PMID:37981050] |
6. Fang Ruiyue, Zhao Ying, Lin Shiyuan, Wei Yue, Chen Hui. (2023) Promoting oral absorption of Panax notoginseng saponins via thiolated trimethyl chitosan and wheat germ agglutinin–modified nanoformulation. Drug Delivery and Translational Research, (1-16). [PMID:37787882] |
7. Yajing Wang, Ziwei Ding, Shiqun Lv, Jie Liu, Jie Pan, Yingcong Yu, Jun Gao, Xianfeng Huang. (2023) Development of tLyP-1 functionalized nanoliposomes with tunable internal water phase for glioma targeting. JOURNAL OF LIPOSOME RESEARCH, [PMID:36974836] |
8. Liping Zhang, Yuan Xu, Wenjuan Cao, Shibao Xie, Lu Wen, Gang Chen. (2023) Understanding the translocation mechanism of PLGA nanoparticles across round window membrane into the inner ear: a guideline for inner ear drug delivery based on nanomedicine. International Journal of Nanomedicine, [PMID:29403277] |
9. Zhang Lin, Dong Yi, Lu Yunhao, Mo Rui, He Qiang. (2023) Photolysis and cytotoxicity of the potentially toxic composition of daylily flower: colchicine. Journal of Food Measurement and Characterization, 17 (3): (2978-2987). [PMID:] |
10. Zhong Wenzhao, Guo Feng, Chen Fangman, Law Man-Kay, Lu Jun, Shao Dan, Yu Hua, Chan Ging, Chen Meiwan. (2022) A multifunctional oxidative stress nanoamplifier with ROS amplification and GSH exhaustion for enhanced chemodynamic therapy. Frontiers in Pharmacology, 13 [PMID:36438812] |
11. Yuhan Yang, Yangyi Chen, Dianpeng Li, Shiyuan Lin, Hui Chen, Wei Wu, Wei Zhang. (2023) Linolenic acid conjugated chitosan micelles for improving the oral absorption of doxorubicin via fatty acid transporter. CARBOHYDRATE POLYMERS, 300 (120233). [PMID:36372473] |
12. Baogui Xu, Jiawen Zheng, Xiaoxiao Tian, Falei Yuan, zhongliang Liu, Yafeng Zhou, Zuisu Yang, Xianjun Ding. (2022) Protective mechanism of traditional Chinese medicine guizhi fuling pills against carbon tetrachloride-induced kidney damage is through inhibiting oxidative stress, inflammation and regulating the intestinal flora. PHYTOMEDICINE, 101 (154129). [PMID:35490491] |
13. Fenglei Zhang, Xuejing Pei, Xiaoxia Peng, Dongxia Gou, Xiao Fan, Xuefei Zheng, Chengcheng Song, Yifa Zhou, Sisi Cui. (2022) Dual crosslinking of folic acid-modified pectin nanoparticles for enhanced oral insulin delivery. Biomaterials Advances, 135 (212746). [PMID:35929218] |
14. Jihui Zhang, Hongwei Lei, Xiu Li. (2022) The protective effects of S14G-humanin (HNG) against mono-sodium urate (MSU) crystals- induced gouty arthritis. Bioengineered, 13 (1): (345-356). [PMID:34965184] |
15. Yang Zhong, Jiayu Gu, Yaoquan Su, Lingzhi Zhao, Yunyun Zhou, Juanjuan Peng. (2022) Real-time screening of hepatotoxins in natural medicine by peroxynitrite responsive lanthanide-based NIR-II luminescent probes. CHEMICAL ENGINEERING JOURNAL, 433 (133263). [PMID:] |
16. Qing Wang,Jie Chen,Kun Huang,Xin Zhang,Li Xu,Zhi-guo Shi. (2014-12-07) Preparation, characterization and application of N-methylene phosphonic acid chitosan grafted magnesia-zirconia stationary phase.. Analytica chimica acta, 854 (191-201). [PMID:25479884] |
17. Qing Wang,Mao Ye,Li Xu,Zhi-guo Shi. (2015-09-01) A reversed-phase/hydrophilic interaction mixed-mode C18-Diol stationary phase for multiple applications.. Analytica chimica acta, 888 (182-190). [PMID:26320974] |