Colchicine - 98%, high purity , CAS No.64-86-8, Inhibitor of bromodomain containing 4;Antagonist of glycine receptor α1 subunit;Antagonist of glycine receptor α2 subunit;Agonist of TAS2R46;Agonist of TAS2R4;Inhibitor of tubulin beta class I
Colchicine - 98%, high purity , CAS No.64-86-8, Inhibitor of bromodomain containing 4;Antagonist of glycine receptor α1 subunit;Antagonist of glycine receptor α2 subunit;Agonist of TAS2R46;Agonist of TAS2R4;Inhibitor of tubulin beta class I
Colchicine is an inhibitor of microtubule polymerization which blocks chromosome segregation during meiosis. Consequently, Colchicine is used to induce polyploidy (tetraploid) in plant cells.Inhibitor of microtubule formation (K i = 2.1 μM). Antimitotic,
Storage Temp
Argon charged
Shipped In
Normal
Grade
Moligand™
Action Type
AGONIST, ANTAGONIST, INHIBITOR
Mechanism of action
Inhibitor of bromodomain containing 4;Antagonist of glycine receptor α1 subunit;Antagonist of glycine receptor α2 subunit;Agonist of TAS2R46;Agonist of TAS2R4;Inhibitor of tubulin beta class I
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
Product Description Colchicine is a tricyclic alkaloid that can stay in circulation for 20 to 40 hours post intake. Leucocytes harbour maximum colchicine. It contains three hexameric rings termed A, B and C. Product Application Colchicine has been used: as an inhibitor of tubulin polymerization in bone-marrow-derived macrophages for the inhibition of in vitro neurite outgrowth in human neuronal cells as microtubule destabilizer to induce peripheral neuropathy in induced pluripotent stem cell derived neurons (iPSC-Neurons)
1.Pinto AP et al.. (2022) IL-6 deletion decreased REV-ERBα protein and influenced autophagy and mitochondrial markers in the skeletal muscle after acute exercise.. Front Immunol, 13 (953272). [PMID:36311768]
2.Pinto AP et al.. (2021) Impact of Different Physical Exercises on the Expression of Autophagy Markers in Mice.. Int J Mol Sci, 22 (5):[PMID:33807902]
3.da Rocha AL et al.. (2020) Moderate, but Not Excessive, Training Attenuates Autophagy Machinery in Metabolic Tissues.. Int J Mol Sci, 21 (22):[PMID:33182536]
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H2427343
